An introduction to cell population kinetics
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| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London
Arnold
1977
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| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
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| 100 | 1 | |a Aherne, William A. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a An introduction to cell population kinetics |c William A. Aherne ; Richard S. Camplejohn ; Nicholas A. Wright |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a London |b Arnold |c 1977 | |
| 300 | |a VIII, 88 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Cell Division | |
| 650 | 4 | |a Cell populations | |
| 650 | 4 | |a Cytokinesis | |
| 650 | 4 | |a Kinetics | |
| 700 | 1 | |a Camplejohn, Richard S. |e Verfasser |4 aut | |
| 700 | 1 | |a Wright, Nicholas A. |e Verfasser |4 aut | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-001422901 | |
Datensatz im Suchindex
| DE-BY-TUM_call_number | 0023 20259 |
|---|---|
| DE-BY-TUM_katkey | 305356 |
| DE-BY-TUM_location | Mag |
| DE-BY-TUM_media_number | 040080134369 |
| _version_ | 1820858792619802624 |
| adam_text | IMAGE 1
CONTENTS
PREFACE III
1 INTRODUCTION 1
1.1 WHAT IS CELL POPULATION KINETICS? 1
1.2 CELL DIVISION 1
1.3 THE CONTROL OF CELL DIVISION 2
1.4 THE CONTROL OF POPULATION SIZE 2
1.4.1 CONTROL BY SELF-INHIBITION 3
1.4.2 CONTROL BY CONTACT INHIBITION 3
1.4.3 CONTROL BY STIMULATION, EXOGENOUS OR ENDOGENOUS 4
1.4.4 CYCLIC AMP AND CYCLIC GMP 5
SUMMARY 6
2 CELL CYCLE EVENTS 8
2.1 DISTINGUISHABLE PHASES OF THE CELL CYCLE 8
2.2 POPULATION STATES ASSOCIATED WITH THE CELL CYCLE 9
2.3 AGE DISTRIBUTION OF CELLS WITHIN A POPULATION 11
2.3.1 THE EFFECT OF AGE DISTRIBUTION ON KINETIC CALCULATIONS 12
2.3.2 DECYCLING AND RECYCLING 13
2.4 CELL BIRTH AND LOSS RATES AND POPULATION GROWTH RATES 13
2.5 HOW THESE EQUATIONS ARE USED IN PRACTICE 15
SUMMARY 15
3 HOW TO ANALYSE THE CELL CYCLE: I 17
3.1 THE SAMPLE CELL COUNT FOR THE MITOTIC INDEX 17
3.2 ANALYSIS BY ARRESTING MITOSIS IN METAPHASE 18
3.2.1 METAPHASE ARREST (STATHMOKINESIS) 18
3.2.2 SOME STATISTICAL ASPECTS OF MITOTIC AND METAPHASE INDICES 21
SUMMARY 25
4 HOW TO ANALYSE THE CELL CYCLE: II 27
4.1 AUTORADIOGRAPHY 27
IMAGE 2
VI CONTENTS
4.2 THE LABELLING INDEX 27
4.3 DOUBLE LABELLING TECHNIQUES ( 3 H AND 14 C) 28
4.4 STATISTICAL EVALUATION OF LABELLING INDICES 31
4.5 THE FRACTION OF LABELLED MITOSES (FLM) TECHNIQUE 31
4.6 CONTINUOUS LABELLING 35
4.7 COMBINED METAPHASE BLOCKADE AND CONTINUOUS LABELLING 37 4.8 GRAIN
COUNTING 39
4.9 SCINTILLATION COUNTING 40
4.10 MICRODENSITOMETRY 41
4.11 CELL DAMAGE DUE TO SELF-IRRADIATION 42
SUMMARY 42
5 CELL POPULATIONS; THEORY AND PRACTICE 44
5.1 THE RELEVANCE OF POPULATION ANALYSIS 44
5.2 CLASSIFICATION OF CELL POPULATIONS: I 44
5.3 CLASSIFICATION OF CELL POPULATIONS: II 45
5.4 A SIMPLE MODEL OF A RENEWAL CELL POPULATION 46
5.5 A SIMPLE MODEL OF AN EXPANDING CELL POPULATION 50
SUMMARY 53
6 THE DYNAMICS OF GROWTH 55
6.1 GROWTH PARAMETERS 55
6.2 TECHNIQUES FOR ESTIMATING THE GROWTH FRACTION 56
6.3 CELL LOSS 57
6.4 GROWTH EQUATIONS 58
SUMMARY 60
7 WORKED EXAMPLES OF CYTOKINETIC ANALYSIS 62
7.1 THE SMALL BOWEL RENEWAL SYSTEM 62
7.2 EXPERIMENTAL STUDY OF A BALB/C MOUSE SARCOMA 68
7.2.1 KINETICS OF THE 7-DAY TUMOURS 70
7.2.2 THE 14-AND 21-DAY TUMOURS 74
7.2.3 MICRODENSITOMETRY 76
7.2.4 SUMMARY AND COMMENTS ON THE MOUSE TUMOUR STUDIES 77
7.3 HUMAN TUMOUR KINETICS 77
GLOSSARY OF CYTOKINETIC TERMS 81
SUGGESTIONS FOR FURTHER READING 86
INDEX 87
|
| any_adam_object | 1 |
| author | Aherne, William A. Camplejohn, Richard S. Wright, Nicholas A. |
| author_facet | Aherne, William A. Camplejohn, Richard S. Wright, Nicholas A. |
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| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 574 - [Unassigned] |
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| dewey-search | 574.8/766 |
| dewey-sort | 3574.8 3766 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 1. publ. |
| format | Book |
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| id | DE-604.BV002166955 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T10:31:30Z |
| institution | BVB |
| isbn | 0713142944 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-001422901 |
| oclc_num | 4135275 |
| open_access_boolean | |
| owner | DE-91 DE-BY-TUM DE-188 |
| owner_facet | DE-91 DE-BY-TUM DE-188 |
| physical | VIII, 88 S. Ill., graph. Darst. |
| publishDate | 1977 |
| publishDateSearch | 1977 |
| publishDateSort | 1977 |
| publisher | Arnold |
| record_format | marc |
| spellingShingle | Aherne, William A. Camplejohn, Richard S. Wright, Nicholas A. An introduction to cell population kinetics Cell Division Cell populations Cytokinesis Kinetics |
| title | An introduction to cell population kinetics |
| title_auth | An introduction to cell population kinetics |
| title_exact_search | An introduction to cell population kinetics |
| title_full | An introduction to cell population kinetics William A. Aherne ; Richard S. Camplejohn ; Nicholas A. Wright |
| title_fullStr | An introduction to cell population kinetics William A. Aherne ; Richard S. Camplejohn ; Nicholas A. Wright |
| title_full_unstemmed | An introduction to cell population kinetics William A. Aherne ; Richard S. Camplejohn ; Nicholas A. Wright |
| title_short | An introduction to cell population kinetics |
| title_sort | an introduction to cell population kinetics |
| topic | Cell Division Cell populations Cytokinesis Kinetics |
| topic_facet | Cell Division Cell populations Cytokinesis Kinetics |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001422901&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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