Filtration in the pharmaceutical industry
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Dekker
1987
|
| Schriftenreihe: | Advances in parenteral sciences
3. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
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| 300 | |a XIX, 1091 S. |b Ill., graph. Darst. | ||
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| 490 | 1 | |a Advances in parenteral sciences |v 3. | |
| 500 | |a Literaturangaben | ||
| 650 | 4 | |a Filtration | |
| 650 | 4 | |a Pharmacie - Technique | |
| 650 | 4 | |a Drug Industry | |
| 650 | 4 | |a Filters and filtration | |
| 650 | 4 | |a Filtration | |
| 650 | 4 | |a Pharmacy |x Technique | |
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Datensatz im Suchindex
| _version_ | 1804115459194224640 |
|---|---|
| adam_text | FILTRATION IN THE PHARMACEUTICAL INDUSTRY THEODORE H. MELTZER CAPITOLA
CONSULTING CO. ARLINGTON, VIRGINIA AND SENIOR CONSULTANT BRUNSWICK
TECHNETICS (FILTERITE CORP.) TIMONIUM, MARYLAND WITH CONTRIBUTIONS BY
ERIC W. BLAKIE, F. RAYMOND GABLER, HARWOOD GREEN, HYMAN B. KATZ, JULIUS
Z. KNAPP, ALVIN LIEBERMAN, DAVID S. LINTON, ROSALIE M. MANDARO MARCEL
DEKKER, INC. NEW YORK * BASEL CONTENTS SERIES I INTRODUCTION V FOREWORD
VII PREFACE IX CONTRIBUTORS XIX PART I FILTERS 1 1 DEPTH FILTERS,
PARTICLES, AND FILTER RATINGS 3 1.1 FILTRATION 3 1.2 DEPTH-TYPE FILTERS
8 1.3 FILTER-MEDIUM MIGRATION 31 1.4 DIFFERENTIAL PRESSURE EFFECTS ON
THE FILTRATION PROCESS 37 » 1.5 DEPTH FILTER/MEMBRANE COMPARISONS 38 1.6
PREFILTER ACTION 39 1.7 NOMINAL AND ABSOLUTE RATINGS 40 1.8 PARTICLES 41
1.9 FILTER PERMEABILITY 50 1.10 FILTER CAPACITY 52 1.11 PARTICLE
DEFORMABILITY 58 REFERENCES 58 2 MEMBRANE POROSITY: ITS ORIGINS AND
MODIFICATIONS 61 2.1 OVERVIEW OF MEMBRANE POROSITY 61 2.2 TRACK-ETCH
MEMBRANES 62 2.3 POROUS POLYTETRAFLUOROETHYLENE 66 2.4 GENESIS OF
POROSITY IN SOLUTION-CAST FILMS 70 2.5 PHASE-INVERSION MEMBRANES 76 2.6
PORE COLLAPSE 79 2.7 CLEARING OF MEMBRANE 80 2.8 ORIENTATION EFFECTS 80
XI CONTENTS 2.9 INFLUENCES ON TENSILE AND ELONGATION PROPERTIES 83 2.10
MEMBRANE VARIABILITY IN MANUFACTURE 85 REFERENCES 85 3 FILTER POROSITY
CHARACTERISTICS 87 3.1 NUMERICAL PORE DIMENSIONS 87 3.2 PORE-SIZE
DISTRIBUTION 100 3.3 PORE SHAPES 122 3.4 IMPLICATION OF THE LARGEST PORE
127 3.5 IMPLICATIONS OF BREADTH OF PORE-SIZE DISTRIBUTIONS 128 3.6
ANISOTROPIC PORE STRUCTURES 133 3.7 EFFECT OF PORE LENGTH ON FLOW AND
RETENTION 138 REFERENCES 13 9 4 FILTER/FLUID INTERACTIONS 143 4.1 SCOPE
OF CONSIDERED INTERACTIONS 143 4.2 EXTRACTABLES 143 4.3 STRUCTURAL
COMPATIBILITIES 159 4.4 ADSORPTIVE REMOVAL OF PREPARATIONAL COMPONENTS
BY FILTERS 174 REFERENCES 178 5 CHARGE-MODIFIED DEPTH FILTERS:
CATIONIC-CHARGE- MODIFIED NYLON MEMBRANES 183 ROSALIE M. MANDARO 5.1
OVERVIEW 183 5.2 DEPTH FILTER MATERIALS 183 5.3 TYPICAL AND ATYPICAL
PROPERTIES OF DEPTH FILTERS 184 5.4 ASBESTOS*THE FIRST CMD FILTER 184
5.5 DEVELOPMENT OF NONASBESTOS DEPTH FILTERS 186 5.6 USE OF CMD FILTERS
IN BLOOD FRACTIONATION 187 5.7 MEASUREMENT OF SURFACE.CHARGE DENSITY ON
CMD FILTERS 187 5.8 CMD FILTER USE IN PHARMACEUTICAL PROCESSING 194 5.9
CONCLUSIONS: CHARGE-MODIFIED DEPTH FILTERS 196 5.10 CATIONIC
CHARGE-MODIFIED NYLON MEMBRANES 197 5.11 CONCLUSIONS: CATION
CHARGE-MODIFIED NYLON MEMBRANES 205 REFERENCES 206 6 QUALITY ASSURANCE
OF FILTERS FOR FLUID CLARIFICATION 209 HYMAN B. KATZ 6.1 INTRODUCTION
209 6.2 PRODUCT DEVELOPMENT 209 6.3 MANUFACTURING 211 6.4 CONTAMINATION
CONTROL 213 6.5 CLEANLINESS LEVELS 214 6.6 PERFORMANCE TESTING 216 6.7
TECHNICAL SUPPORT 218 REFERENCES 218 CONTENTS XIII 7 THE INTEGRITY TESTS
219 7.1 INTRODUCTION 219 7.2 BUBBLE POINT AND ORGANISM RETENTION 220 7.3
CAUSES OF BUBBLE-POINT DEVIATIONS 227 7.4 BUBBLE-POINT PROTOCOL 248 7.5
MEASUREMENT AT ROBUST AIR FLOWS 251 7.6 BUBBLE-POINT TESTING AT FIXED
AIR PRESSURE LEVELS 253 7.7 POLYMER CONTRIBUTION TO BUBBLE-POINT VALUES
25 5 7.8 SIGNIFICANCE OF THE WILLIAMS STRUCTURE 260 7.9 THE KNEE REGION
OF THE CURVE 263 7.10 DIFFUSIVE AIR FLOW AS INTEGRITY INDICATOR 266 7.11
EFFECTS OF MEMBRANE ANISOTROPY 274 7.12 SINGLE-POINT INTEGRITY TEST
MEASUREMENT 275 7.13 SENSITIVITY OF DIFFUSIVE AIR FLOWS 278 7.14
PRESSURE-HOLD TEST 279 7.15 SENSITIVITY OF INTEGRITY TESTS 281 7.16
WATER INTRUSION TEST 282 7.17 INITIAL INTEGRITY TEST 284 7.18 AUTOMATED
INTEGRITY TESTING DEVICES 286 7.19 FLOW RATIO TEST 290 7.20 CONCLUSIONS
292 REFERENCES 2 93 PART II FILTRATION 299 8 FILTRATIVE PARTICLE REMOVAL
FROM LIQUIDS 299 8.1 PARTICLE TRAPPING MECHANISMS 299 8.2 ADSORPTIVE
SEQUESTRATION 301 8.3 THE MODELING OF FILTER BLOCKING 324 8.4 PRACTICAL
IMPLICATIONS OF ADSORPTIVE SEQUESTRATION 330 8.5 RELIABILITY OF
ADSORPTIVE SEQUESTRATIONS 332 8.6 SUMMARY OF TRAPPING FORCES AND THEIR
LOCI 336 8.7 THE STERILIZING FILTER * 337 8.8 RETENTION OF LATEX SPHERES
350 REFERENCES 363 9 FILTRATIVE PARTICLE REMOVAL FROM CASES 369 9.1
INTRODUCTION 369 9.2 FERMENTATION AIR FILTERS 369 9.3 VENT FILTERS 373
9.4 SERVICE AIR FILTRATION 374 9.5 MECHANISMS OPERATIVE IN GAS
FILTRATIONS 374 9.6 HYDROPHOBICITY 387 9.7 STEAM STERILIZABILITY 387 9.8
INTEGRITY TESTING 389 9.9 MULTIPLE STEAMINGS 390 9.10 CRITERIA FOR AIR
FILTERS 391 9.11 SIZING OF VENT FILTERS 391 9.12 VALIDATION OF AIR
FILTERS 391 9.13 SUMMARY OF GAS FILTRATION 400 XIV CONTENTS 9.14 STEAM
401 REFERENCES 406 10 FLOW AND PRESSURE, FILTER SIZING, AND FILTER
SYSTEM DESIGN 409 HARWOOD GREEN AND THEODORE H. MELTZER 10.1 INFLUENCES
ON FLOW 409 10.2 PRESSURE CONSIDERATIONS 410 10.3 CONSTANT-PRESSURE
FILTRATIONS 413 10.4 CONSUMPTION OF FILTER CAPACITY 416 10.5
CONSTANT-FLOW FILTRATIONS 420 10.6 MANUFACTURERS CATALOG INFORMATION
420 10.7 THE UTILIZATION OF FLOW DECAY MEASUREMENTS 421 10.8 SIZING
PREFILTER/FINAL FILTER COMBINATIONS 434 10.9 DESIGN CONSIDERATIONS 450
REFERENCES 452 11 PRINCIPLES OF TANGENTIAL FLOW FILTRATION: APPLICATIONS
TO BIOLOGICAL PROCESSING 453 F. RAYMOND GABLER 11.1 INTRODUCTION 453
11.2 FILTER TYPES USED IN TANGENTIAL FLOW 454 11.3 MICROPOROUS MEMBRANES
AND SECONDARY LAYER FORMATION 456 11.4 DEFINITION OF TERMS 457 11.5
THEORY OF TANGENTIAL FLOW FILTRATION 459 11.6 PRACTICAL ASPECTS OF
TANGENTIAL FLOW FILTRATION 460 11.7 CONCENTRATION POLARIZATION 466 11.8
DETERMINING OPTIMUM OPERATING PARAMETERS VIA TOTAL RECYCLE 468 11.9
MEMBRANE FOULING 473 11.10 PARTICULATE LOADING 475 11.11 TANGENTIAL FLOW
APPLICATIONS 476 11.12 TANGENTIAL FLOW EQUIPMENT 486 11.13 SUMMARY 488
REFERENCES 488 PART III PARTICLES 491 12 VIABLE/NONVIABLE PARTICLE AND
PYROGEN RETENTION 493 12.1 PARENTERAL REQUIREMENTS 493 12.2
STERILIZATION BY FILTRATION 494 12.3 STERILIZING FILTER EVALUATION 509
12.4 OTHER-THAN STERILIZING GRADE FILTERS 514 12.5 STERILITY TESTING 518
12.6 DETERMINATION OF BIOBURDEN 524 12.7 DEPYROGENATION 525 12.8
PARTICULATE MATERIAL 527 12.9 FILTER VALIDATION 531 12.10 GROW-THROUGH
537 REFERENCES 541 CONTENTS XV 13 DETECTION AND MEASUREMENT OF PARTICLES
IN BULK PHARMACEUTICAL LIQUIDS 545 ALVIN LIEBERMAN 13.1 DEFINITION OF
SCOPE 545 13.2 SAMPLE HANDLING PROBLEMS 546 13.3 PARTICLE MEASUREMENT
METHODS FOR PHARMACEUTICAL LIQUIDS 557 13.4 ELECTRONIC OPERATION 575
13.5 LIQUID FEEDERS AND FLOW CONTROLS 577 13.6 OPERATING PARAMETERS FOR
OPTICAL PARTICLE COUNTERS 579 13.7 LIQUID FLOW RATE EFFECTS 581 13.8
CALIBRATION BASES 581 13.9 DILUTION EFFECTS 581 13.10 MEASUREMENT
PROCEDURES 582 13.11 CALCULATION OF RESULTS 583 13.12 CONCLUSIONS 584
REFERENCES 584 14 DETECTION AND MEASUREMENT OF PARTICLES IN SEALED
CONTAINERS 587 JULIUS I. KNAPP 14.1 INTRODUCTION 587 14.2 ANALYTICAL AND
VISUAL PHARMACEUTICAL PARTICULATE STANDARDS 589 14.3 VISIBLE PARTICULATE
SOURCES 590 14.4 VIAL STOPPERS: A MAJOR PARTICULATE SOURCE 590 14.5
PHYSIOLOGICAL EFFECT OF PARTICIPATES IN PARENTERAL PRODUCTS 595 14.6 THE
PROBABILISTIC INSPECTION 600 14.7 A PROBABILISTIC EVALUATION OF THE
VISUAL INSPECTION FOR PARTICULATES 602 14.8 EFFECT OF CONTAINER CLARITY
ON VISUAL PARTICULATE INSPECTION 604 14.9 REJECTION RATE ANALYSIS BY
HISTOGRAM SHOWING DISTRIBUTION OF VISUAL PARTICULATE REJECTS 605 14.10
VISUAL INSPECTION REJECT RATE UNMASKED AS A MORTALITY TABLE EFFECT 605
14.11 RELATIONSHIPS OF REJECTION PROBABILITY AND REJECTS IN A NORMAL
PARENTERAL PRODUCTION BATCH 607 14.12 EFFECT OF SECOND OR CULL
INSPECTION OF FINAL REJECT DISTRIBUTION IN A NORMAL PARENTERAL
PRODUCTION BATCH 607 14.13 TRANSFORMATION OF RULE-OF-THUMB QUALITY
CATEGORIES INTO PROBABILISTICALLY DEFINED REGIONS 607 14.14 INSPECTION
SECURITY EVALUATED WITH THE REJECTION ZONE EFFICIENCY (RZE) PARAMETER
612 14.15 ACCEPT/REJECT DISCRIMINATION EVALUATED WITH THE REJECT RATE IN
THE ACCEPT AND GRAY ZONE (RAG) PARAMETER 615 XVI CONTENTS 14.16 THE
SCIENCE OF VISUAL INSPECTION 615 14.17 EFFECT ON THE 50% DETECTABILITY
RESPONSE OF A TARGET WHEN CONTRAST AND BACKGROUND LUMINANCE ARE VARIED
IN TIME-LIMITED TRIALS 617 14.18 REVIEW OF BIOPHYSICS VISION EXPERIMENTS
SUPPORTING AND EXTENDING PARTICULATE INSPECTION EXPERIMENTS RESULTS 618
14.19 IES LIGHTING RECOMMENDATIONS FOR VARIOUS VISUAL TASKS 622 14.20
INSPECTOR SELECTION AND VALIDATION 623 14.21 BOOTSTRAP INSPECTOR
SELECTION UNDER ACTUAL INSPECTION CONDITIONS USING RZE AND RAG 629 14.22
DURABILITY OF RZE AND RAG DETERMINATIONS FOR A VALIDATED INSPECTOR GROUP
632 14.23 DURABILITY OF INDIVIDUAL AND GROUP RZE AND RAG PARAMETERS 633
14.24 THE CORE VALIDATION PROBLEM FOR VISUAL AND OPTICAL INSPECTION 634
14.25 COMPARISON OF DIFFERENT PROBABILISTIC INSPECTION TECHNIQUES 634
14.26 TWO-DIMENSIONAL REJECTION PROBABILITY DISTRIBUTION 638 14.27
APPLICATION OF THE MANUAL INSPECTION PERFORMANCE YARDSTICK 640 14.28
OBJECTIVE STANDARDS 644 14.29 HOLOGRAMMIC EVALUATION OF AUTOMATED AND
VISUAL INSPECTION PERFORMANCE 647 14.30 VISIBILITY REGION BOUNDARIES FOR
ACTUAL PARTICULATES IN PARENTERAL PRODUCTS 656 14.31 ACCURACY
LIMITATIONS IMPOSED BY SAMPLING INSPECTION PROCEDURES 657 14.32 UHLIR S
MODEL OF PARTICULATE INSPECTION 658 14.33 A PRACTICAL COST-EFFECTIVE
INSPECTION VALIDATION PROCEDURE 661 14.34 INSPECTION SYSTEMS: PRACTICAL
CONSIDERATIONS 699 14.35 OBJECTIVE PHYSICAL CRITERIA VALIDATIONS 704
14.36 COMMERCIAL SYSTEMS 705 REFERENCES 705 15 PUMP TYPES AND THEIR
SELECTION 709 DAVID S. LINTON 15.1 INTRODUCTION 709 15.2 DEFINITION OF
TERMS 709 15.3 PUMP PARAMETERS 713 15.4 MATERIALS OF COMPOSITON 714 15.5
STERILIZATION OF PUMPS 715 15.6 TYPES OF PUMPS 717 15.7 SUMMARY 725
REFERENCE 726 16 FILTER AND FILTER HOLDER/HOUSING DESIGN 727 16.1
GENERAL FILTER HOLDER/HOUSING DESIGN 727 16.2 DISK VERSUS CARTRIDGE
CONFIGURATION 770 CONTENTS XVII 16.3 FILTER CARTRIDGES 772 16.4
STERILIZATION OF FILTER AND HOLDER 780 16.5 DISPOSABLE FILTER DEVICES
784 REFERENCES 787 PART V PRACTICAL FILTRATION APPLICATIONS 789 17 WATER
PURIFICATION 791 17.1 GRADES OF WATER 791 17.2 VARIOUS WATER
PURIFICATION TREATMENTS 795 17.3 OVERVIEW OF WATER PURIFICATION 809 17.4
DEIONIZATION BY ION-EXCHANGE REACTIONS 811 17.5 REVERSE OSMOSIS 838 17.6
ULTRAFILTRATION MEMBRANES 854 17.7 ULTRAVIOLET IRRADIATION OF WATER 855
17.8 ELECTRODIALYSIS 858 17.9 DISTILLATION OF WATER 860 17.10 USE OF
FILTERS IN WATER PURIFICATION 882 17.11 WATER STORAGE AND DISTRIBUTION
885 17.12 WATER FOR INJECTION INSTALLATIONS 897 REFERENCES 913 18
PYROGENS, AND THE DEPYROGENATION OF SOLUTIONS WITH ULTRAFILTRATION
MEMBRANES 919 F. RAYMOND GABLER 18.1 BIOCHEMISTRY OF BACTERIAL PYROGENS
919 18.2 CLASSICAL METHODS OF REMOVING PYROGENS 922 18.3 REMOVING
PYROGENS WITH ULTRAFILTRATION MEMBRANE FILTERS 923 18.4 SCALING UP A UF
SYSTEM FROM LABORATORY TO PRODUCTION 936 18.5 SUMMARY ! 938 REFERENCES
938 19 THEORY AND PRACTICE OF COMPRESSED AIR FILTRATION AND
STERILIZATION IN THE PRODUCTION OF ANTIBIOTICS 941 ERIC W. BLAKIE 19.1
INTRODUCTION 941 19.2 COMPRESSED AIR CONTAMINATION 942 19.3
PREFILTRATION 945 19.4 THE COMPRESSED AIR STERILIZATION FILTER 945 19.5
FILTRATION THEORY 950 19.6 THE MODERN AIR STERILIZATION CARTRIDGE 952
19.7 FILTER HOUSINGS 954 19.8 PERFORMANCE COMPARISON 957 19.9 FILTER
SELECTION AND SIZING 962 19.10 INSTALLATION 964 19.11 STEAM
STERILIZATION 967 19.12 IN SITU STEAM STERILIZATION PROCEDURE 967 19.13
PROBLEM AREAS 968 19.14 FILTER CARTRIDGE LIFE 968 19.15 INTEGRITY
TESTING 970 XVIII , CONTENTS 19.16 MICROBIAL TESTING 974 19.17
CONCLUSION 977 REFERENCES 978 20 FILTRATION IN THE PHARMACEUTICAL
PROCESSING PRACTICES 979 20.1 REGULATORY FUNCTIONS 979 20.2 CLEANLINESS
OF PEOPLE AND FACILITIES 982 20.3 STERILIZATION OF FILTERS 983 20.4
REPEATED ADVICE CONCERNING FILTRATION 986 20.5 LARGE-VOLUME PARENTERALS
986 20.6 SMALL-VOLUME PARENTERALS 996 20.7 OPHTHALMIC PREPARATIONS 1003
20.8 ANTIBIOTICS 1008 20.9 SPECIFIC ELABORATIONS 1018 20.10 BLOOD,
PLASMA, AND SERUM 1021 20.11 TISSUE CULTURE MEDIUM FILTRATION 1040 20.12
FILTRATION IN VACCINES PREPARATION 1045 REFERENCES 1051 POSTSCRIPT 1055
PRESENT STATUS 1055 FUTURE DEVELOPMENTS 1055 BASIS FOR PREDICTION 1057
AUTHOR INDEX 1059 SUBJECT INDEX 1069
|
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| ctrlnum | (OCoLC)14188414 (DE-599)BVBBV001040657 |
| dewey-full | 615/.191 |
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| dewey-raw | 615/.191 |
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| dewey-sort | 3615 3191 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| id | DE-604.BV001040657 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:22:57Z |
| institution | BVB |
| isbn | 0824775198 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000629164 |
| oclc_num | 14188414 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-355 DE-BY-UBR |
| owner_facet | DE-19 DE-BY-UBM DE-355 DE-BY-UBR |
| physical | XIX, 1091 S. Ill., graph. Darst. |
| publishDate | 1987 |
| publishDateSearch | 1987 |
| publishDateSort | 1987 |
| publisher | Dekker |
| record_format | marc |
| series | Advances in parenteral sciences |
| series2 | Advances in parenteral sciences |
| spelling | Filtration in the pharmaceutical industry Theodore H. Meltzer ... New York u.a. Dekker 1987 XIX, 1091 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in parenteral sciences 3. Literaturangaben Filtration Pharmacie - Technique Drug Industry Filters and filtration Pharmacy Technique Filtration (DE-588)4017164-4 gnd rswk-swf Pharmazeutische Industrie (DE-588)4045696-1 gnd rswk-swf Pharmazeutische Technologie (DE-588)4045699-7 gnd rswk-swf Pharmazeutische Technologie (DE-588)4045699-7 s Filtration (DE-588)4017164-4 s DE-604 Pharmazeutische Industrie (DE-588)4045696-1 s Meltzer, Theodore H. Sonstige oth Advances in parenteral sciences 3. (DE-604)BV000021432 3. GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000629164&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Filtration in the pharmaceutical industry Advances in parenteral sciences Filtration Pharmacie - Technique Drug Industry Filters and filtration Pharmacy Technique Filtration (DE-588)4017164-4 gnd Pharmazeutische Industrie (DE-588)4045696-1 gnd Pharmazeutische Technologie (DE-588)4045699-7 gnd |
| subject_GND | (DE-588)4017164-4 (DE-588)4045696-1 (DE-588)4045699-7 |
| title | Filtration in the pharmaceutical industry |
| title_auth | Filtration in the pharmaceutical industry |
| title_exact_search | Filtration in the pharmaceutical industry |
| title_full | Filtration in the pharmaceutical industry Theodore H. Meltzer ... |
| title_fullStr | Filtration in the pharmaceutical industry Theodore H. Meltzer ... |
| title_full_unstemmed | Filtration in the pharmaceutical industry Theodore H. Meltzer ... |
| title_short | Filtration in the pharmaceutical industry |
| title_sort | filtration in the pharmaceutical industry |
| topic | Filtration Pharmacie - Technique Drug Industry Filters and filtration Pharmacy Technique Filtration (DE-588)4017164-4 gnd Pharmazeutische Industrie (DE-588)4045696-1 gnd Pharmazeutische Technologie (DE-588)4045699-7 gnd |
| topic_facet | Filtration Pharmacie - Technique Drug Industry Filters and filtration Pharmacy Technique Pharmazeutische Industrie Pharmazeutische Technologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000629164&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000021432 |
| work_keys_str_mv | AT meltzertheodoreh filtrationinthepharmaceuticalindustry |