QSAR and strategies in the design of bioactive compounds proceedings of the 5. European Symposium on Quantitative Structure-Activity Relationships, Bad Segeberg 198436 ed. by J. K. Seydel
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adam_text | QSAR AND STRATEGIES IN THE DESIGN OF BIOACTIVE COMPOUNDS PROCEEDINGS OF
THE FIFTH EUROPEAN SYMPOSIUM ON QUANTITATIVE STRUCTURE-ACTIVITY
RELATIONSHIPS BAD SEGEBERG 1984 EDITED BY J. K. SEYDEL
UNIVERSITATSBIBLIOTHEK HANNOVER TECHNISCHE INFORMATIONSBIBLIOTHEK VCH
CONTENTS PREFACE V PAPERS OPENING LECTURE TO WHICH EXTENT CAN RECEPTOR
EVENTS BE EXTRAPOLATED FROM DRUG-INDUCED RESPONSES? 3 H. LIILLMANN, A.
ZIEGLER SESSION I METHODS IN QSAR CHAIRMAN: R. M. HYDE EVOLUTION OF QSAR
METHODOLOGY AND THE ROLE OF NEWER COMPUTATIONAL TECHNIQUES 19 M. WISE ON
THE EVALUATION OF STRUCTURAL ACTIVITY PATTERNS 30 R. FRANKE, W. J.
STREICH, S. DOVE A NEW APPROACH IN COMPUTER-AIDED DERIVATION OF QSAR 39
B. JERMAN-BLAZIC, M. RANDIC, J. ZEROVNIK STRUCTURE-ACTIVITY ANALYSIS
USING HIERARCHICALLY ORGANIZED STRUCTURAL MOLECULAR DESCRIPTORS 49 W.
SCHUBERT SESSION II QSAR PARAMETERS CHAIRMAN: V AUSTEL QSAR PARAMETERS
59 R. FRANKE AMINO ACID SIDE CHAIN PARAMETERS AND THEIR USE IN QSAR
STUDIES OF POLYPEPTIDE HORMONES 79 J.-L. FAUCHERE THE POTENTIAL ENERGY
FUNCTION AND THE ROLE OF CONFORMATIONAI ENTROPY OF CLONIDINE-LIKE
IMIDAZOLIDINES FOR THE AFFINITY TO ALPHA-ADRENERGIC RECEPTORS 83 F.
AVBELJ, D. HADZI RAPID CALCULATION OF ELECTRONIC EFFECTS IN ORGANIC
MOLECULES 90 J. GASTEIGER, M.G. HUTCHINGS, M. MARSILI, H. SAILER THE
STERIMOL APPROACH. POSSIBLE CONTRIBUTION TO RECEPTOR MAPPING 98 A.
VERLOOP _ VII CONTENS SESSION III MOLECULAR MODELLING CHAIRMAN: C.
HANSCH APPLICATIONS OF SYSTEMATIC SEARCH TO STRUCTURE-ACTIVITY STUDIES
107 G. R. MARSHALL, S. NARUTO, I. MOTOC, R. NELSON, C. SCHNEIDER, T.
NUKES, J. MEARA DISTANCE GEOMETRY QSAR: CURRENT ACHIEVEMENTS AND FUTURE
EXTENSIONS 116 A. K. GHOSE, G. M. CRIPPEN A QSAR ANALYSIS OF THE BINDING
OF BENZYIPYRIMIDINES TO DIHYDROFOLATE REDUCTASE USING MOLECULAR SHAPE
ANALYSIS 120 M. MABILIA, R. A. PEARLSTEIN, A. J. HOPFINGER THEORETICAL
INVESTIGATION OF THE METHOTREXATE-DIHYDROFOLATE REDUCTASE INTERACTION
COMPLEX 127 H.-D. HOLTJE, R ZUNKER STRUCTURE AND ACTIVITY OF
PROGESTERONE DERIVATIVES 135 F. J. ZEELEN SESSION IV APPLICATION OF QSAR
ANALYSIS IN MEDICINAL CHEMISTRY CHAIRMAN: J.G. TOPLISS QSAR AND GRAPHICS
LIGAND RECEPTOR INTERACTION 145 C. HANSCH COMPARISON BETWEEN X-RAY
CRYSTALLOGRAPHIC DATA AND PHYSICOCHEMICAL PARAMETERS WITH RESPECT TO
THEIR INFORMATION ABOUT THE CALCIUM CHANNEL ANTAGONISTIC ACTIVITY OF
4-PHENYL-1,4-DIHYDROPYRIDINES 146 P BERNTSSON TOWARDS A QUANTUM
CHEMICALLY DERIVED INTERACTION MODEL FOR NONSTEROIDAL ANTIINFLAMMA- TORY
DRUGS: QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS FOR SUBSTITUTED
BENZOIC AND SALICYLIC ACIDS AND PHENOLS 153 J. GERHARDS, E. L MEHLER
TETRACYCLIC NEUROLEPTICS STRUCTURALLY RELATED TO MIANSERIN 162 J.
KELDER, TH. DE BOER, J.S. DE GRAAF, J. H. WIERINGA SESSION V APPLICATION
OF QSAR ANALYSIS IN PHARMACOKINETICS CHAIRMAN: H. KUBINYI MULTIVARIATE
METHODS IN QUANTITATIVE STRUCTURE PHARMACOKINETICS RELATIONSHIP ANALYSIS
173 K.-J. SCHAPER, J. K. SEYDEL VIII CONTENS BIOLOGICAL ACTIVITY -
CHEMICAL STRUCTURE - TIME OF ACTION 190 M. TICHY, Z. ROTH RATIONALLY
DESIGNED MODEL WITH GENERAL APPLICABILITY FOR ABSORPTION BY PASSIVE
DIFFUSION 198 F H. N. DE HAAN, A. C. A. JANSEN SESSION VI APPLICATION OF
QSAR IN AGROCHEMISTRY CHAIRMAN: W DRABER APPLICATIONS OF QUANTITATIVE
STRUCTURE-ACTIVITY ANALYSES TO PESTICIDES AND GROWTH REGULATORS 207 T.
FUJITA THE USE OF MULTIVARIATE DATA SETS IN THE STUDY OF
STRUCTURE-ACTIVITY RELATIONSHIPS OF SYNTHETIC PYRETHROID INSECTICIDES:
PART I THE RELATIONSHIP BETWEEN PHYSICOCHEMICAL AND PHARMACOKINETIC
PROPERTIES 219 R.M. SZYDLO, M.G. FORD, R. GREENWOOD, D.W. SALT THE USE
OF MULTIVARIATE DATA SETS IN THE STUDY OF STRUCTURE-ACTIVITY
RELATIONSHIPS OF SYNTHETIC PYRETHROID INSECTICIDES: PART II THE
RELATIONSHIPS BETWEEN PHARMACOKINETICS AND TOXICITY 229 R.M. SZYDLO,
M.G. FORD, R. GREENWOOD, D.W. SALT QSAR OF 1,4-BENZOQUINONES IN
PHOTOSYNTHETIC SYSTEMS 238 W. OETTMEIER, K. MASSON, H.-J. SOIL, E.
OLSCHEWSKI POSTER SESSION I METHODS AND PARAMETERS IN QSAR CHAIRMAN: M.
TUTE MANUAL DESIGN OF TEST SERIES FOR FREE-WILSON ANALYSIS 247 V. AUSTEL
PHARMACOCHEMICAL DISTANCE BASED ON DERIVED FRAGMENT CODES AND BIOLOGICAL
SCREENING DATA 251 M. BLUNCK, E. MOELLER INCORPORATION OF PHYSICAL
CHEMICAL PARAMETERS IN RECEPTOR MAPPING BASED ON DISTANCE GEOMETRY 256
T. BULTSMA, M. R. LINSCHOTEN QSAR FOR PEPTIDE BIOACTIVITY 260 M. CHARTON
LONIZATION CONSTANTS BY CURVE FITTING: FURTHER APPLICATION TO THE
DETERMINATION OF PARTI- TION COEFFICIENTS 264 F H. CLARKE IX CONTENS
SUBSTITUENT INTERACTIONS IN THE LIPOPHILICITY OF DISUBSTITUTED BENZENES
AS ASSESSED BY RP-HPLC 268 N. EL TAYAR, H. VAN DE WATERBEEMD, B. TESTA
LINEAR PROGRAMMING; A NOVEL TECHNIQUE IN QSAR 272 Z. GABANYI, A. LOPATA
MOLAR VOLUME IN DRUG DESIGN 273 M. GRYLLAKI, H. VAN DE WATERBEEMD, B.
TESTA ESTIMATION OF LOG P VALUE USING THE PHYSICOCHEMICAL PARAMETERS
DERIVED FROM MOLECULAR STRUCTURE 277 K. KASAI, A. TOMONAGA QUANTITATIVE
CORRELATION OF PROTON AFFINITIES AND LONIZATION POTENTIALS WITH
STRUCTURE 281 I. A. KOPPEL, U.H. MOLDER FACTOR ANALYSIS AND CANONICAL
CORRELATION ANALYSIS IN DRUG RESEARCH 285 W. LAASS PH-DEPENDENCE OF
HYDROPHOBIC PARAMETERS IN SETS OF LONIZABLE DRUGS 290 M.I. LA ROTONDA,
G. AMATO, F BARBATO, G. CALIENDO, C. SILIPO, A. VITTORIA COMPUTER
CALCULATION OF OCTANOL/WATER PARTITION COEFFICIENTS OF ORGANIC SOLUTES
FROM STRUCTURE 294 A. J. LEO NEW GEOMETRICAL AND ELECTRONIC DESCRIPTORS
OF MOLECULES FOR STRUCTURE-ACTIVITY RELATIONSHIPS 299 R. SCORDAMAGLIA,
L. BARINO THE PLS DATA ANALYTIC METHOD IN QSAR 305 B. SKAGERBERG, W. J.
DUNN III, S. HELLBERG, S. WOLD POSTER SESSION II APPLICATION OF QSAR IN
MEDICINAL CHEMISTRY AND PHARMACOKINETICS CHAIRMAN: J. DEARDEN
QUANTITATIVE RELATIONSHIP BETWEEN TRANS-PLACENTAL TRANSFER AND
PHYSICOCHEMICAL PROPER- TIES OF A SERIES OF HETEROGENOUS DRUGS 313 J. R
AKBARALY, J.J. LENG, G. BOZLER, J. K. SEYDEL ENZYMATIC HYDROLYSES OF
ALANYL-ALANINE-ANILIDES BY DIPEPTIDYL PEPTIDASE IV: A CONTRI- BUTION OF
QSAR TO THE INVESTIGATION OF THE MECHANISM 318 A. BARTH, K. NEUBERT, G.
SCHWARZ, G. FISCHER, S. DOVE, R. FRANKE COMPUTER ASSISTED DESIGN OF A
NOVEL TYPE OF TRANQUILLANT 324 F DARVAS, A. LOPATA, Z. BUDAI, L. PETOCZ
CONTENS MATHEMATICAL MODELLING OF THE DRUG TRANSPORT PROCESS -
INCORPORATION OF REALISTIC TRANS- FER RATE CONSTANTS AND A DISSOLUTION
STEP 328 J.C. DEARDEN, M.S. TOWNEND APPLICATION OF TOPOLOGICAL MOLECULAR
TRANSFORM TO DESIGN CARDIOSELECTIVE B-BLOCKING AGENTS 333 Z. GABANYI
SELECTED METHODS OF QUANTITATIVE STRUCTURE-ACTIVITY ANALYSIS IN THE
DEVELOPMENT OF BETA- ADRENERGIC BLOCKING DRUGS 337 A. GRISK, H. BERCHER,
A. GRUSKA PHYSICOCHEMICAL CRITERIA FOR RIGHT-SHIFTING THE OXYGEN
DISSOCIATION CURVE OF WHOLE BLOOD 341 R.M. HYDE, D.J. LIVINGSTONE
ANTITHROMBOTIC ACTIVITIES OF ARYLALIPHATIC ACIDS - QSAR APPROACH 345 M.
KUCHAF, V. REJHOLEC BETA-ADRENERGIC BLOCKING AGENTS: SYNTHESIS AND
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS OF
1-LSOPROPYLAMINO-3-(2 -SUBSTITUTED NAPHTHOXY)-PROPAN-2-OLS 349 V. M.
KULKAMI, S. B. GUNDEWAR QUANTITATIVE STRUCTURE-STABILITY RELATIONSHIPS
AMONG INCLUSION COMPLEXES OF CYCLODEX- TRINS. PART 2. STEROID HORMONES
353 A. LOPATA, F DARVAS, A. STADLER-SZOKE, J. SZEJTLI STUDIES ON THE
DIFFERENT INFLUENCE OF ORGANIC NITRATES ON GUANYLATE CYCLASE ACTIVITY
AND CORONARY FLOW 357 E. NOACK, H. SCHRODER, R. BONN QSAR IN MAPPING OF
HISTAMINE H, RECEPTORS 361 A. K. SAXENA, M. SAXENA, S. K. AGRAWAL, G. K.
PATNAIK RIGID CALCIUM ANTAGONISTS OF THE NIFEDIPINE-TYPE: GEOMETRIC
REQUIREMENTS FOR THE DIHYDROPYRIDINE RECEPTOR 366 W. SEIDEL, H. MEYER, L
BORN, S. KAZDA, W. DOMPERT REACTIVITY AND STEREOCHEMICAL PARAMETERS IN
QSAR FOR CARCINOGENIC POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVES 370 Z.
SIMON, D. CIUBOTARIU, A.I BALABAN QUANTUM MECHANICAL STUDY OF .THE
ACTIVITY OF SOME H 2 -RECEPTOR AGONISTS OF HISTAMINE 374 YG. SMEYERS,
FJ. ROMERO-SANCHEZ, A. HERNANDEZ-LAGUNA SUCCESSFUL PREDICTION OF A
POTENT NON-HORMONAL ANTI-INFLAMMATORY: SPECIFIC AND NON- SPECIFIC MODELS
OF BIOLOGICAL ACTIVITY 378 S. H. UNGER, PS. CHEUNG, P FEIGNER, J. M.
MUCHOWSKI QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS OF A SERIES OF
NITROIMIDAZOLES 382 H.A. VERPLANKEN, C. J. DE RANTER XI CONTENS POSTER
SESSION III QSAR IN AGROCHEMISTRY AND IN ENVIRONMENTAL SAFETY CHAIRMAN:
P MOSER STEPWISE CANONICAL CORRELATION ANALYSIS: A NEW APPROACH FOR THE
STUDY OF STRUCTURAL REQUIREMENTS OF BROAD SPECTRUM ACTIVITY 389 B.
BORDAS LIPOPHILICITY CONSTANTS DERIVED FROM HPLC TO DESCRIBE THE
ENVIRONMENTAL BEHAVIOUR OF PHENOLS 393 W. BUTTE THE PREDICTION OF
CHEMICAL, PHYSICAL AND BIOLOGICAL PROPERTIES OF HALOAROMATIC COMPOUNDS
398 M. CHARTON, B. CHARTON THEORETICAL CONSIDERATIONS ABOUT THE POSSIBLE
MODE OF ACTION OF PRECOCENES 403 Z. DINYA, T. TIMAR, S. HOSZTAFI, A.
FODOR, R DEAK, A. SOMOGYI, M. BERENYI STRUCTURE-ACTIVITY RELATIONSHIPS
OF INHIBITORS OF A FUNGAL CHITIN SYNTHETASE 410 H. P FISCHER, E. EBERT,
R MOSER QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS IN THE INHIBITION
OF PHOTO-SYSTEM II IN CHLOROPLASTS BY PHENYLUREAS 414 E. KAKKIS, V C.
PALMIRE JR., C. D. STRONG, W. BERTSCH, C. HANSCH, U. SCHIRMER STEPWISE
VARIATION STRATEGY IN THE EVALUATION OF QSAR FOR FUNGICIDAL
2-ANILINOPYRIMI- DINES BY MEANS OF DISCRIMINANT ANALYSIS 416 G. KRAUSE,
M. KLEPEL, R. FRANKE A QSAR STUDY OF THE RAT LD 50 FOR ALCOHOLS 420 R. L
LIPNICK, C. S. PRITZKER, D. L BENTLEY ON THE MECHANISM OF ANTIFUNGAL
ACTION OF NITROALCOHOL DERIVATIVES 424 A. LOPATA, F DARVAS, G. MIKITE,
A. KIS-TAMAS, G. GULLNER, G. JOSEPOVITS THE APPLICATION OF QSAR
STRATEGIES IN THE DESIGN OF A FAMILY OF BROAD SPECTRUM PYRETHROID
INSECTICIDES BASED ON BIPHENYL-LIKE ALCOHOLS 425 E. L PLUMMER
OPTIMIZATION OF AUXINE ACTIVITY OF BENZOTRIAZOLES BY QSAR 429 F
SPARATORE, M. I. LA ROTONDA, G. CALIENDO, C. SILIPO, A. VITTORIA AUTHOR
INDEX 434 SUBJECT INDEX 437 XII
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genre_facet | Konferenzschrift 1984 Segeberg |
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indexdate | 2024-07-09T15:14:17Z |
institution | BVB |
institution_GND | (DE-588)2081665-0 |
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physical | XII, 442 S. |
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publishDate | 1985 |
publishDateSearch | 1985 |
publishDateSort | 1985 |
publisher | VCH |
record_format | marc |
spelling | QSAR and strategies in the design of bioactive compounds proceedings of the 5. European Symposium on Quantitative Structure-Activity Relationships, Bad Segeberg 198436 ed. by J. K. Seydel Weinheim u.a. VCH 1985 XII, 442 S. txt rdacontent n rdamedia nc rdacarrier Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf QSAR (DE-588)4205429-1 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1984 Segeberg gnd-content QSAR (DE-588)4205429-1 s DE-604 Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 s Pharmakologie (DE-588)4045687-0 s Seydel, Joachim K. Sonstige oth European Symposium on Quantitative Structure Activity Relationships 5 1984 Bad Segeberg Sonstige (DE-588)2081665-0 oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000283844&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | QSAR and strategies in the design of bioactive compounds proceedings of the 5. European Symposium on Quantitative Structure-Activity Relationships, Bad Segeberg 198436 ed. by J. K. Seydel Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd Pharmakologie (DE-588)4045687-0 gnd QSAR (DE-588)4205429-1 gnd |
subject_GND | (DE-588)4183784-8 (DE-588)4045687-0 (DE-588)4205429-1 (DE-588)1071861417 |
title | QSAR and strategies in the design of bioactive compounds proceedings of the 5. European Symposium on Quantitative Structure-Activity Relationships, Bad Segeberg 198436 ed. by J. K. Seydel |
title_auth | QSAR and strategies in the design of bioactive compounds proceedings of the 5. European Symposium on Quantitative Structure-Activity Relationships, Bad Segeberg 198436 ed. by J. K. Seydel |
title_exact_search | QSAR and strategies in the design of bioactive compounds proceedings of the 5. European Symposium on Quantitative Structure-Activity Relationships, Bad Segeberg 198436 ed. by J. K. Seydel |
title_full | QSAR and strategies in the design of bioactive compounds proceedings of the 5. European Symposium on Quantitative Structure-Activity Relationships, Bad Segeberg 198436 ed. by J. K. Seydel |
title_fullStr | QSAR and strategies in the design of bioactive compounds proceedings of the 5. European Symposium on Quantitative Structure-Activity Relationships, Bad Segeberg 198436 ed. by J. K. Seydel |
title_full_unstemmed | QSAR and strategies in the design of bioactive compounds proceedings of the 5. European Symposium on Quantitative Structure-Activity Relationships, Bad Segeberg 198436 ed. by J. K. Seydel |
title_short | QSAR and strategies in the design of bioactive compounds |
title_sort | qsar and strategies in the design of bioactive compounds proceedings of the 5 european symposium on quantitative structure activity relationships bad segeberg 198436 ed by j k seydel |
title_sub | proceedings of the 5. European Symposium on Quantitative Structure-Activity Relationships, Bad Segeberg 198436 ed. by J. K. Seydel |
topic | Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd Pharmakologie (DE-588)4045687-0 gnd QSAR (DE-588)4205429-1 gnd |
topic_facet | Struktur-Aktivitäts-Beziehung Pharmakologie QSAR Konferenzschrift 1984 Segeberg |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000283844&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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