Overcoming the penetration depth limit in optical microscopy: Adaptive optics and wavefront shaping
Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time, current applications are mostly limited to research settings. This is due to the aberrations and multiple scattering that is induced by the inhomogeneous ref...
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| Veröffentlicht in: | Journal of innovative optical health science 2019-07, Vol.12 (4), p.1930002-1-1930002-18 |
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| container_end_page | 1930002-18 |
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| container_issue | 4 |
| container_start_page | 1930002-1 |
| container_title | Journal of innovative optical health science |
| container_volume | 12 |
| creator | Ahn, Cheolwoo Hwang, Byungjae Nam, Kibum Jin, Hyungwon Woo, Taeseong Park, Jung-Hoon |
| description | Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time, current applications are mostly limited to research settings. This is due to the aberrations and multiple scattering that is induced by the inhomogeneous refractive boundaries that are inherent to biological systems. However, recent developments in adaptive optics and wavefront shaping have shown that high resolution optical imaging is not fundamentally limited only to the observation of single cells, but can be significantly enhanced to realize deep tissue imaging. To provide insight into how these two closely related fields can expand the limits of bio imaging, we review the recent progresses in their performance and applicable range of studies as well as potential future research directions to push the limits of deep tissue imaging. |
| doi_str_mv | 10.1142/S1793545819300027 |
| format | Article |
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| ispartof | Journal of innovative optical health science, 2019-07, Vol.12 (4), p.1930002-1-1930002-18 |
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| source | Directory of Open Access Journals (DOAJ); World Scientific Open; Free E-Journal (出版社公開部分のみ） |
| subjects | Adaptive optics Adaptive systems High resolution Image resolution in-vivo imaging Microscopy multiple scattering optical aberration Optical microscopy Optics Penetration depth Wave fronts wavefront shaping |
| title | Overcoming the penetration depth limit in optical microscopy: Adaptive optics and wavefront shaping |
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