COMPARISON OF AMINOLEVULINIC ACID AND ITS METHYL ESTER MEDIATED PHOTOCYTOTOXICITY ON HUMAN NASOPHARYNGEAL CARCINOMA CELLS

COMPARISON OF AMINOLEVULINIC ACID AND ITS METHYL ESTER MEDIATED PHOTOCYTOTOXICITY ON HUMAN NASOPHARYNGEAL CARCINOMA CELLS

Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of innovative optical health science 2012-04, Vol.5 (2), p.1250007
Hauptverfasser: YOW, CHRISTINE M. N., WU, RICKY W. K., HUANG, ZHENG
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 2
container_start_page 1250007
container_title Journal of innovative optical health science
container_volume 5
creator YOW, CHRISTINE M. N.
WU, RICKY W. K.
HUANG, ZHENG
description Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed that human NPC cells were sensitive to both ALA- and MAL-mediated PDT. However, ALA was more effective than MAL, possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin (PpIX) in NPC cells. Neither ALA nor MAL caused any significant genotoxicity. The ALA-based PDT might be a useful modality in the treatment of NPC.
doi_str_mv 10.1142/S1793545812500071
format Article
fullrecord <record><control><sourceid>worldscientific_cross</sourceid><recordid>TN_cdi_worldscientific_primary_S1793545812500071</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>S1793545812500071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2861-1b436c228d8c9d724a3d21961a80741ed8f3d7159196b8cef2a205d4935aed9b3</originalsourceid><addsrcrecordid>eNplkF1LwzAUhoMoOKc_wLv8gWqSfqWXIc3WQNqMNhN7Vbqmhcp00gqyf2_Ghje7OR_v4XnhvAA8Y_SCcUBeKxwnfhiEFJMQIRTjG7A4SV5MUHh7mU_3e_Awzx8IRT7CaAGOXOcbVspKF1CvIMtloZV42ypZSA4ZlylkRQqlqWAuTFYrKCojSrekkhmRwk2mjea1cfVdcmlq6Jyybc4KWLBKbzJW1sVaMAU5K7lzzxnkQqnqEdwN7X7uny59CbYrYXjmKb2WnCmvIzTCHt4FftQRQi3tEhuToPUtwUmEW4riAPeWDr6NcZg4bUe7fiCt-9gGLo22t8nOXwJ89u2mwzxP_dB8T-NnOx0bjJpTds1Vdo5BZ-b3MO3t3I391884jN0_eo38AYvmZs8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>COMPARISON OF AMINOLEVULINIC ACID AND ITS METHYL ESTER MEDIATED PHOTOCYTOTOXICITY ON HUMAN NASOPHARYNGEAL CARCINOMA CELLS</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>YOW, CHRISTINE M. N. ; WU, RICKY W. K. ; HUANG, ZHENG</creator><creatorcontrib>YOW, CHRISTINE M. N. ; WU, RICKY W. K. ; HUANG, ZHENG</creatorcontrib><description>Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed that human NPC cells were sensitive to both ALA- and MAL-mediated PDT. However, ALA was more effective than MAL, possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin (PpIX) in NPC cells. Neither ALA nor MAL caused any significant genotoxicity. The ALA-based PDT might be a useful modality in the treatment of NPC.</description><identifier>ISSN: 1793-5458</identifier><identifier>EISSN: 1793-7205</identifier><identifier>DOI: 10.1142/S1793545812500071</identifier><language>eng</language><publisher>World Scientific Publishing Company</publisher><ispartof>Journal of innovative optical health science, 2012-04, Vol.5 (2), p.1250007</ispartof><rights>2012, World Scientific Publishing Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2861-1b436c228d8c9d724a3d21961a80741ed8f3d7159196b8cef2a205d4935aed9b3</citedby><cites>FETCH-LOGICAL-c2861-1b436c228d8c9d724a3d21961a80741ed8f3d7159196b8cef2a205d4935aed9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>YOW, CHRISTINE M. N.</creatorcontrib><creatorcontrib>WU, RICKY W. K.</creatorcontrib><creatorcontrib>HUANG, ZHENG</creatorcontrib><title>COMPARISON OF AMINOLEVULINIC ACID AND ITS METHYL ESTER MEDIATED PHOTOCYTOTOXICITY ON HUMAN NASOPHARYNGEAL CARCINOMA CELLS</title><title>Journal of innovative optical health science</title><description>Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed that human NPC cells were sensitive to both ALA- and MAL-mediated PDT. However, ALA was more effective than MAL, possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin (PpIX) in NPC cells. Neither ALA nor MAL caused any significant genotoxicity. The ALA-based PDT might be a useful modality in the treatment of NPC.</description><issn>1793-5458</issn><issn>1793-7205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNplkF1LwzAUhoMoOKc_wLv8gWqSfqWXIc3WQNqMNhN7Vbqmhcp00gqyf2_Ghje7OR_v4XnhvAA8Y_SCcUBeKxwnfhiEFJMQIRTjG7A4SV5MUHh7mU_3e_Awzx8IRT7CaAGOXOcbVspKF1CvIMtloZV42ypZSA4ZlylkRQqlqWAuTFYrKCojSrekkhmRwk2mjea1cfVdcmlq6Jyybc4KWLBKbzJW1sVaMAU5K7lzzxnkQqnqEdwN7X7uny59CbYrYXjmKb2WnCmvIzTCHt4FftQRQi3tEhuToPUtwUmEW4riAPeWDr6NcZg4bUe7fiCt-9gGLo22t8nOXwJ89u2mwzxP_dB8T-NnOx0bjJpTds1Vdo5BZ-b3MO3t3I391884jN0_eo38AYvmZs8</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>YOW, CHRISTINE M. N.</creator><creator>WU, RICKY W. K.</creator><creator>HUANG, ZHENG</creator><general>World Scientific Publishing Company</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201204</creationdate><title>COMPARISON OF AMINOLEVULINIC ACID AND ITS METHYL ESTER MEDIATED PHOTOCYTOTOXICITY ON HUMAN NASOPHARYNGEAL CARCINOMA CELLS</title><author>YOW, CHRISTINE M. N. ; WU, RICKY W. K. ; HUANG, ZHENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2861-1b436c228d8c9d724a3d21961a80741ed8f3d7159196b8cef2a205d4935aed9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YOW, CHRISTINE M. N.</creatorcontrib><creatorcontrib>WU, RICKY W. K.</creatorcontrib><creatorcontrib>HUANG, ZHENG</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of innovative optical health science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOW, CHRISTINE M. N.</au><au>WU, RICKY W. K.</au><au>HUANG, ZHENG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COMPARISON OF AMINOLEVULINIC ACID AND ITS METHYL ESTER MEDIATED PHOTOCYTOTOXICITY ON HUMAN NASOPHARYNGEAL CARCINOMA CELLS</atitle><jtitle>Journal of innovative optical health science</jtitle><date>2012-04</date><risdate>2012</risdate><volume>5</volume><issue>2</issue><spage>1250007</spage><pages>1250007-</pages><issn>1793-5458</issn><eissn>1793-7205</eissn><abstract>Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed that human NPC cells were sensitive to both ALA- and MAL-mediated PDT. However, ALA was more effective than MAL, possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin (PpIX) in NPC cells. Neither ALA nor MAL caused any significant genotoxicity. The ALA-based PDT might be a useful modality in the treatment of NPC.</abstract><pub>World Scientific Publishing Company</pub><doi>10.1142/S1793545812500071</doi></addata></record>
fulltext fulltext
identifier ISSN: 1793-5458
ispartof Journal of innovative optical health science, 2012-04, Vol.5 (2), p.1250007
issn 1793-5458
1793-7205
language eng
recordid cdi_worldscientific_primary_S1793545812500071
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
title COMPARISON OF AMINOLEVULINIC ACID AND ITS METHYL ESTER MEDIATED PHOTOCYTOTOXICITY ON HUMAN NASOPHARYNGEAL CARCINOMA CELLS
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T22%3A15%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-worldscientific_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=COMPARISON%20OF%20AMINOLEVULINIC%20ACID%20AND%20ITS%20METHYL%20ESTER%20MEDIATED%20PHOTOCYTOTOXICITY%20ON%20HUMAN%20NASOPHARYNGEAL%20CARCINOMA%20CELLS&rft.jtitle=Journal%20of%20innovative%20optical%20health%20science&rft.au=YOW,%20CHRISTINE%20M.%20N.&rft.date=2012-04&rft.volume=5&rft.issue=2&rft.spage=1250007&rft.pages=1250007-&rft.issn=1793-5458&rft.eissn=1793-7205&rft_id=info:doi/10.1142/S1793545812500071&rft_dat=%3Cworldscientific_cross%3ES1793545812500071%3C/worldscientific_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true