Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region
Modulation of the rhythmic activity of local field potentials (LFP) in neuronal networks could be a mechanism of deep brain stimulation (DBS). However, exact changes of LFP during the periods of high-frequency stimulation (HFS) of DBS are unclear because of the interference of dense stimulation arti...
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| Veröffentlicht in: | Journal of integrative neuroscience 2016-03, Vol.15 (1), p.1-17 |
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| creator | Yu, Ying Feng, Zhouyan Cao, Jiayue Guo, Zheshan Wang, Zhaoxiang Hu, Na Wei, Xuefeng |
| description | Modulation of the rhythmic activity of local field potentials (LFP) in neuronal networks could be a mechanism of deep brain stimulation (DBS). However, exact changes of LFP during the periods of high-frequency stimulation (HFS) of DBS are unclear because of the interference of dense stimulation artifacts with high amplitudes. In the present study, we investigated LFP changes induced by HFS of afferent axons in the hippocampal CA1 region of urethane-anesthetized rats by using a proper algorithm of artifact removal. Afterward, the LFP changes in the frequency bands of
δ
,
θ
,
α
,
β
and
γ
rhythms were studied by power spectrum analysis and coherence analysis for the recorded signals collected in the pyramidal layer and in the stratum radiatum of CA1 region before, during and after 1-min long 100 and 200
Hz HFS. Results showed that the power of LFP rhythms in higher-frequency band (
γ
rhythm) increased in the pyramidal layer and the power of LFP rhythms in lower-frequency bands (
θ
,
α
and
β
rhythms) decreased in the stratum radiatum during HFS. The synchronization of
θ
rhythm decreased and the synchronization of
γ
rhythm increased during HFS in the stratum radiatum. These results suggest that axonal HFS could modulate LFP rhythms in the downstream brain areas with a plausible underlying mechanism of partial axonal blockage induced by HFS. The study provides new evidence to support the mechanism of DBS modulating rhythmic activity of neuronal populations. |
| doi_str_mv | 10.1142/S0219635216500011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_ADCHV</sourceid><recordid>TN_cdi_worldscientific_primary_S0219635216500011</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1790940552</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4181-42a7c99e867e0ba89516ee3609a196689c44ce2df10735010073fd6b113a3e3f3</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0EokvhB_RS-cglMBN_JD5Wq7YgFXEAJG6R1xl3XSVxamcF--_r1ZaqUi-cRtY87yPbL2NnCJ8QZf35B9RotFA1agUAiK_YChvVVFK2v1-z1WFdHfYn7F3Od1DOwsBbdlJraQCkXLH0Lfa7wS4hTjx6PkRnB-4DDT2f40LTEuyQ-WbPt-F2W_lE9zua3J7nJYzPctZ7SoXm9m-cMg8TX7ZUMvNchONcnOsL5IluC_-evfFFSh8e5yn7dXX5c_2luvl-_XV9cVM5iS1WsraNM4Za3RBsbGsUaiKhwdjyaN0aJ6WjuvcIjVCAUIbv9QZRWEHCi1P28eidUyy3zks3huxoGOxEcZc7bAwYCUrV_4E2CpWuhS4oHlGXYs6JfDenMNq07xC6Qyvdi1ZK5vxRv9uM1D8l_tVQADgCf2Ia-uzC4eN9cE_kS-cDS2KWdw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1775156236</pqid></control><display><type>article</type><title>Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region</title><source>World Scientific Open</source><creator>Yu, Ying ; Feng, Zhouyan ; Cao, Jiayue ; Guo, Zheshan ; Wang, Zhaoxiang ; Hu, Na ; Wei, Xuefeng</creator><creatorcontrib>Yu, Ying ; Feng, Zhouyan ; Cao, Jiayue ; Guo, Zheshan ; Wang, Zhaoxiang ; Hu, Na ; Wei, Xuefeng</creatorcontrib><description>Modulation of the rhythmic activity of local field potentials (LFP) in neuronal networks could be a mechanism of deep brain stimulation (DBS). However, exact changes of LFP during the periods of high-frequency stimulation (HFS) of DBS are unclear because of the interference of dense stimulation artifacts with high amplitudes. In the present study, we investigated LFP changes induced by HFS of afferent axons in the hippocampal CA1 region of urethane-anesthetized rats by using a proper algorithm of artifact removal. Afterward, the LFP changes in the frequency bands of
δ
,
θ
,
α
,
β
and
γ
rhythms were studied by power spectrum analysis and coherence analysis for the recorded signals collected in the pyramidal layer and in the stratum radiatum of CA1 region before, during and after 1-min long 100 and 200
Hz HFS. Results showed that the power of LFP rhythms in higher-frequency band (
γ
rhythm) increased in the pyramidal layer and the power of LFP rhythms in lower-frequency bands (
θ
,
α
and
β
rhythms) decreased in the stratum radiatum during HFS. The synchronization of
θ
rhythm decreased and the synchronization of
γ
rhythm increased during HFS in the stratum radiatum. These results suggest that axonal HFS could modulate LFP rhythms in the downstream brain areas with a plausible underlying mechanism of partial axonal blockage induced by HFS. The study provides new evidence to support the mechanism of DBS modulating rhythmic activity of neuronal populations.</description><identifier>ISSN: 0219-6352</identifier><identifier>EISSN: 1757-448X</identifier><identifier>DOI: 10.1142/S0219635216500011</identifier><identifier>PMID: 26490044</identifier><language>eng</language><publisher>England: World Scientific Publishing Company</publisher><subject>Algorithms ; Animals ; Axons - physiology ; Biophysical Phenomena - physiology ; CA1 Region, Hippocampal - cytology ; Electric Stimulation ; Evoked Potentials - physiology ; Male ; Nerve Net - physiology ; Periodicity ; Rats ; Rats, Sprague-Dawley ; Spectrum Analysis</subject><ispartof>Journal of integrative neuroscience, 2016-03, Vol.15 (1), p.1-17</ispartof><rights>2016, The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4181-42a7c99e867e0ba89516ee3609a196689c44ce2df10735010073fd6b113a3e3f3</citedby><cites>FETCH-LOGICAL-c4181-42a7c99e867e0ba89516ee3609a196689c44ce2df10735010073fd6b113a3e3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.worldscientific.com/doi/reader/10.1142/S0219635216500011$$EPDF$$P50$$Gworldscientific$$Hfree_for_read</linktopdf><link.rule.ids>314,780,784,27496,27923,27924,55568</link.rule.ids><linktorsrc>$$Uhttp://dx.doi.org/10.1142/S0219635216500011$$EView_record_in_World_Scientific_Publishing$$FView_record_in_$$GWorld_Scientific_Publishing$$Hfree_for_read</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26490044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Ying</creatorcontrib><creatorcontrib>Feng, Zhouyan</creatorcontrib><creatorcontrib>Cao, Jiayue</creatorcontrib><creatorcontrib>Guo, Zheshan</creatorcontrib><creatorcontrib>Wang, Zhaoxiang</creatorcontrib><creatorcontrib>Hu, Na</creatorcontrib><creatorcontrib>Wei, Xuefeng</creatorcontrib><title>Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region</title><title>Journal of integrative neuroscience</title><addtitle>J Integr Neurosci</addtitle><description>Modulation of the rhythmic activity of local field potentials (LFP) in neuronal networks could be a mechanism of deep brain stimulation (DBS). However, exact changes of LFP during the periods of high-frequency stimulation (HFS) of DBS are unclear because of the interference of dense stimulation artifacts with high amplitudes. In the present study, we investigated LFP changes induced by HFS of afferent axons in the hippocampal CA1 region of urethane-anesthetized rats by using a proper algorithm of artifact removal. Afterward, the LFP changes in the frequency bands of
δ
,
θ
,
α
,
β
and
γ
rhythms were studied by power spectrum analysis and coherence analysis for the recorded signals collected in the pyramidal layer and in the stratum radiatum of CA1 region before, during and after 1-min long 100 and 200
Hz HFS. Results showed that the power of LFP rhythms in higher-frequency band (
γ
rhythm) increased in the pyramidal layer and the power of LFP rhythms in lower-frequency bands (
θ
,
α
and
β
rhythms) decreased in the stratum radiatum during HFS. The synchronization of
θ
rhythm decreased and the synchronization of
γ
rhythm increased during HFS in the stratum radiatum. These results suggest that axonal HFS could modulate LFP rhythms in the downstream brain areas with a plausible underlying mechanism of partial axonal blockage induced by HFS. The study provides new evidence to support the mechanism of DBS modulating rhythmic activity of neuronal populations.</description><subject>Algorithms</subject><subject>Animals</subject><subject>Axons - physiology</subject><subject>Biophysical Phenomena - physiology</subject><subject>CA1 Region, Hippocampal - cytology</subject><subject>Electric Stimulation</subject><subject>Evoked Potentials - physiology</subject><subject>Male</subject><subject>Nerve Net - physiology</subject><subject>Periodicity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spectrum Analysis</subject><issn>0219-6352</issn><issn>1757-448X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ADCHV</sourceid><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhB_RS-cglMBN_JD5Wq7YgFXEAJG6R1xl3XSVxamcF--_r1ZaqUi-cRtY87yPbL2NnCJ8QZf35B9RotFA1agUAiK_YChvVVFK2v1-z1WFdHfYn7F3Od1DOwsBbdlJraQCkXLH0Lfa7wS4hTjx6PkRnB-4DDT2f40LTEuyQ-WbPt-F2W_lE9zua3J7nJYzPctZ7SoXm9m-cMg8TX7ZUMvNchONcnOsL5IluC_-evfFFSh8e5yn7dXX5c_2luvl-_XV9cVM5iS1WsraNM4Za3RBsbGsUaiKhwdjyaN0aJ6WjuvcIjVCAUIbv9QZRWEHCi1P28eidUyy3zks3huxoGOxEcZc7bAwYCUrV_4E2CpWuhS4oHlGXYs6JfDenMNq07xC6Qyvdi1ZK5vxRv9uM1D8l_tVQADgCf2Ia-uzC4eN9cE_kS-cDS2KWdw</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Yu, Ying</creator><creator>Feng, Zhouyan</creator><creator>Cao, Jiayue</creator><creator>Guo, Zheshan</creator><creator>Wang, Zhaoxiang</creator><creator>Hu, Na</creator><creator>Wei, Xuefeng</creator><general>World Scientific Publishing Company</general><scope>ADCHV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201603</creationdate><title>Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region</title><author>Yu, Ying ; Feng, Zhouyan ; Cao, Jiayue ; Guo, Zheshan ; Wang, Zhaoxiang ; Hu, Na ; Wei, Xuefeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4181-42a7c99e867e0ba89516ee3609a196689c44ce2df10735010073fd6b113a3e3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Axons - physiology</topic><topic>Biophysical Phenomena - physiology</topic><topic>CA1 Region, Hippocampal - cytology</topic><topic>Electric Stimulation</topic><topic>Evoked Potentials - physiology</topic><topic>Male</topic><topic>Nerve Net - physiology</topic><topic>Periodicity</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spectrum Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Ying</creatorcontrib><creatorcontrib>Feng, Zhouyan</creatorcontrib><creatorcontrib>Cao, Jiayue</creatorcontrib><creatorcontrib>Guo, Zheshan</creatorcontrib><creatorcontrib>Wang, Zhaoxiang</creatorcontrib><creatorcontrib>Hu, Na</creatorcontrib><creatorcontrib>Wei, Xuefeng</creatorcontrib><collection>World Scientific Open</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of integrative neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Yu, Ying</au><au>Feng, Zhouyan</au><au>Cao, Jiayue</au><au>Guo, Zheshan</au><au>Wang, Zhaoxiang</au><au>Hu, Na</au><au>Wei, Xuefeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region</atitle><jtitle>Journal of integrative neuroscience</jtitle><addtitle>J Integr Neurosci</addtitle><date>2016-03</date><risdate>2016</risdate><volume>15</volume><issue>1</issue><spage>1</spage><epage>17</epage><pages>1-17</pages><issn>0219-6352</issn><eissn>1757-448X</eissn><abstract>Modulation of the rhythmic activity of local field potentials (LFP) in neuronal networks could be a mechanism of deep brain stimulation (DBS). However, exact changes of LFP during the periods of high-frequency stimulation (HFS) of DBS are unclear because of the interference of dense stimulation artifacts with high amplitudes. In the present study, we investigated LFP changes induced by HFS of afferent axons in the hippocampal CA1 region of urethane-anesthetized rats by using a proper algorithm of artifact removal. Afterward, the LFP changes in the frequency bands of
δ
,
θ
,
α
,
β
and
γ
rhythms were studied by power spectrum analysis and coherence analysis for the recorded signals collected in the pyramidal layer and in the stratum radiatum of CA1 region before, during and after 1-min long 100 and 200
Hz HFS. Results showed that the power of LFP rhythms in higher-frequency band (
γ
rhythm) increased in the pyramidal layer and the power of LFP rhythms in lower-frequency bands (
θ
,
α
and
β
rhythms) decreased in the stratum radiatum during HFS. The synchronization of
θ
rhythm decreased and the synchronization of
γ
rhythm increased during HFS in the stratum radiatum. These results suggest that axonal HFS could modulate LFP rhythms in the downstream brain areas with a plausible underlying mechanism of partial axonal blockage induced by HFS. The study provides new evidence to support the mechanism of DBS modulating rhythmic activity of neuronal populations.</abstract><cop>England</cop><pub>World Scientific Publishing Company</pub><pmid>26490044</pmid><doi>10.1142/S0219635216500011</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Algorithms Animals Axons - physiology Biophysical Phenomena - physiology CA1 Region, Hippocampal - cytology Electric Stimulation Evoked Potentials - physiology Male Nerve Net - physiology Periodicity Rats Rats, Sprague-Dawley Spectrum Analysis |
| title | Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region |
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