Expression of lipoma preferred partner in mammary and extramammary Paget disease
Backgound: This study aims to identify the expression of lipoma preferred partner (LPP) in Paget disease (PD) and to further understand the pathogenesis of PD. Methods: Tissue microarray was used to evaluate the expression of LPP by immunohistochemistry in 40 PD patients. The results of LPP expressi...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-12, Vol.99 (51), p.e23443-e23443, Article 23443 |
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| creator | Liu, Ye Wang, Yangbin Qi, Ruiqun Mao, Xiaoyun Jin, Feng |
| description | Backgound: This study aims to identify the expression of lipoma preferred partner (LPP) in Paget disease (PD) and to further understand the pathogenesis of PD. Methods: Tissue microarray was used to evaluate the expression of LPP by immunohistochemistry in 40 PD patients. The results of LPP expression were combined with clinical and histopathological characteristics. Patient files were analyzed retrospectively. Results: Twenty-one cases were mammary Paget disease (MPD) and 19 extramammary Paget disease (EMPD) involving the vulva, scrotum, and penis. LPP was expressed in PD and this expression was significantly greater in MPD versus EMPD (P = .031). The expression of LPP in MPD was significantly related with age (P = .009) and expression of Ki-67 (P = .011). No statistically significant differences were observed in LPP expression as related to sex, body location, and time of PD diagnosis. Conclusions: While LPP is expressed in both MPD and EMPD, the intensity of this expression is greater in MPD. LPP expression is positively correlated with Ki-67 and is more prevalent in middle-aged versus senior MPD patients. Further research is needed to determine its potential role in tumorigenesis and distribution. |
| doi_str_mv | 10.1097/MD.0000000000023443 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_wolte</sourceid><recordid>TN_cdi_wolterskluwer_health_00005792-202012180-00019</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2473740647</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4509-875dd1e99d77007c30c77da44ffbef3799083d35c32af929b3858f8bb23c935d3</originalsourceid><addsrcrecordid>eNqNUU1v1DAUtBCIbhd-ARLKEQml2H5OHF-Q0LYUpFb0AGfLsV-6hiQOdtKWf4_LbpePE748azwzHs0j5AWjJ4wq-eby9IT-PhyEgEdkxSqoy0rV4jFZZbQqpZLiiByn9JVSBpKLp-QIACSjkq3I1dndFDElH8YidEXvpzCYIkMdxoiumEycR4yFH4vBDIOJPwozugLv5mgegCtzjXPhfEKT8Bl50pk-4fP9XJMv788-bz6UF5_OP27eXZRWVFSVjaycY6iUk5JSaYFaKZ0Routa7EAqRRtwUFngplNctdBUTde0LQeroHKwJm93vtPSDugsjjlRr6fo7zPpYLz--2X0W30dbrSUosk1ZINXe4MYvi-YZj34ZLHvzYhhSZoLCVLQOo81gR3VxpBS7ubwDaP6fhf68lT_u4usevlnwoPmofxMaHaEW2xDl6zH0eKBln1qxhtQdb4xtfGzmfOWNmEZ5yx9_f_SzBZ7duhnjOlbv9xi1Fs0_bz9FbySipeccso4a2i5k_0EGXW2Ag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473740647</pqid></control><display><type>article</type><title>Expression of lipoma preferred partner in mammary and extramammary Paget disease</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wolters Kluwer Open Health</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>IngentaConnect Free/Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Liu, Ye ; Wang, Yangbin ; Qi, Ruiqun ; Mao, Xiaoyun ; Jin, Feng</creator><creatorcontrib>Liu, Ye ; Wang, Yangbin ; Qi, Ruiqun ; Mao, Xiaoyun ; Jin, Feng</creatorcontrib><description>Backgound: This study aims to identify the expression of lipoma preferred partner (LPP) in Paget disease (PD) and to further understand the pathogenesis of PD. Methods: Tissue microarray was used to evaluate the expression of LPP by immunohistochemistry in 40 PD patients. The results of LPP expression were combined with clinical and histopathological characteristics. Patient files were analyzed retrospectively. Results: Twenty-one cases were mammary Paget disease (MPD) and 19 extramammary Paget disease (EMPD) involving the vulva, scrotum, and penis. LPP was expressed in PD and this expression was significantly greater in MPD versus EMPD (P = .031). The expression of LPP in MPD was significantly related with age (P = .009) and expression of Ki-67 (P = .011). No statistically significant differences were observed in LPP expression as related to sex, body location, and time of PD diagnosis. Conclusions: While LPP is expressed in both MPD and EMPD, the intensity of this expression is greater in MPD. LPP expression is positively correlated with Ki-67 and is more prevalent in middle-aged versus senior MPD patients. Further research is needed to determine its potential role in tumorigenesis and distribution.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000023443</identifier><identifier>PMID: 33371071</identifier><language>eng</language><publisher>PHILADELPHIA: Lippincott Williams & Wilkins</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Breast Neoplasms - pathology ; Clinical Trial/Experimental Study ; Cytoskeletal Proteins - biosynthesis ; Female ; General & Internal Medicine ; Humans ; Life Sciences & Biomedicine ; LIM Domain Proteins - biosynthesis ; Male ; Medicine, General & Internal ; Middle Aged ; Neoplasms - pathology ; Paget Disease, Extramammary - pathology ; Paget's Disease, Mammary - pathology ; Penile Neoplasms - pathology ; Retrospective Studies ; Science & Technology ; Testicular Neoplasms - pathology ; Tissue Array Analysis ; Vulvar Neoplasms - pathology</subject><ispartof>Medicine (Baltimore), 2020-12, Vol.99 (51), p.e23443-e23443, Article 23443</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000612839600019</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4509-875dd1e99d77007c30c77da44ffbef3799083d35c32af929b3858f8bb23c935d3</citedby><cites>FETCH-LOGICAL-c4509-875dd1e99d77007c30c77da44ffbef3799083d35c32af929b3858f8bb23c935d3</cites><orcidid>0000-0002-1965-5926</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748372/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748372/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2115,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33371071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Ye</creatorcontrib><creatorcontrib>Wang, Yangbin</creatorcontrib><creatorcontrib>Qi, Ruiqun</creatorcontrib><creatorcontrib>Mao, Xiaoyun</creatorcontrib><creatorcontrib>Jin, Feng</creatorcontrib><title>Expression of lipoma preferred partner in mammary and extramammary Paget disease</title><title>Medicine (Baltimore)</title><addtitle>MEDICINE</addtitle><addtitle>Medicine (Baltimore)</addtitle><description>Backgound: This study aims to identify the expression of lipoma preferred partner (LPP) in Paget disease (PD) and to further understand the pathogenesis of PD. Methods: Tissue microarray was used to evaluate the expression of LPP by immunohistochemistry in 40 PD patients. The results of LPP expression were combined with clinical and histopathological characteristics. Patient files were analyzed retrospectively. Results: Twenty-one cases were mammary Paget disease (MPD) and 19 extramammary Paget disease (EMPD) involving the vulva, scrotum, and penis. LPP was expressed in PD and this expression was significantly greater in MPD versus EMPD (P = .031). The expression of LPP in MPD was significantly related with age (P = .009) and expression of Ki-67 (P = .011). No statistically significant differences were observed in LPP expression as related to sex, body location, and time of PD diagnosis. Conclusions: While LPP is expressed in both MPD and EMPD, the intensity of this expression is greater in MPD. LPP expression is positively correlated with Ki-67 and is more prevalent in middle-aged versus senior MPD patients. Further research is needed to determine its potential role in tumorigenesis and distribution.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Breast Neoplasms - pathology</subject><subject>Clinical Trial/Experimental Study</subject><subject>Cytoskeletal Proteins - biosynthesis</subject><subject>Female</subject><subject>General & Internal Medicine</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>LIM Domain Proteins - biosynthesis</subject><subject>Male</subject><subject>Medicine, General & Internal</subject><subject>Middle Aged</subject><subject>Neoplasms - pathology</subject><subject>Paget Disease, Extramammary - pathology</subject><subject>Paget's Disease, Mammary - pathology</subject><subject>Penile Neoplasms - pathology</subject><subject>Retrospective Studies</subject><subject>Science & Technology</subject><subject>Testicular Neoplasms - pathology</subject><subject>Tissue Array Analysis</subject><subject>Vulvar Neoplasms - pathology</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNUU1v1DAUtBCIbhd-ARLKEQml2H5OHF-Q0LYUpFb0AGfLsV-6hiQOdtKWf4_LbpePE748azwzHs0j5AWjJ4wq-eby9IT-PhyEgEdkxSqoy0rV4jFZZbQqpZLiiByn9JVSBpKLp-QIACSjkq3I1dndFDElH8YidEXvpzCYIkMdxoiumEycR4yFH4vBDIOJPwozugLv5mgegCtzjXPhfEKT8Bl50pk-4fP9XJMv788-bz6UF5_OP27eXZRWVFSVjaycY6iUk5JSaYFaKZ0Routa7EAqRRtwUFngplNctdBUTde0LQeroHKwJm93vtPSDugsjjlRr6fo7zPpYLz--2X0W30dbrSUosk1ZINXe4MYvi-YZj34ZLHvzYhhSZoLCVLQOo81gR3VxpBS7ubwDaP6fhf68lT_u4usevlnwoPmofxMaHaEW2xDl6zH0eKBln1qxhtQdb4xtfGzmfOWNmEZ5yx9_f_SzBZ7duhnjOlbv9xi1Fs0_bz9FbySipeccso4a2i5k_0EGXW2Ag</recordid><startdate>20201218</startdate><enddate>20201218</enddate><creator>Liu, Ye</creator><creator>Wang, Yangbin</creator><creator>Qi, Ruiqun</creator><creator>Mao, Xiaoyun</creator><creator>Jin, Feng</creator><general>Lippincott Williams & Wilkins</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1965-5926</orcidid></search><sort><creationdate>20201218</creationdate><title>Expression of lipoma preferred partner in mammary and extramammary Paget disease</title><author>Liu, Ye ; Wang, Yangbin ; Qi, Ruiqun ; Mao, Xiaoyun ; Jin, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4509-875dd1e99d77007c30c77da44ffbef3799083d35c32af929b3858f8bb23c935d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Breast Neoplasms - pathology</topic><topic>Clinical Trial/Experimental Study</topic><topic>Cytoskeletal Proteins - biosynthesis</topic><topic>Female</topic><topic>General & Internal Medicine</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>LIM Domain Proteins - biosynthesis</topic><topic>Male</topic><topic>Medicine, General & Internal</topic><topic>Middle Aged</topic><topic>Neoplasms - pathology</topic><topic>Paget Disease, Extramammary - pathology</topic><topic>Paget's Disease, Mammary - pathology</topic><topic>Penile Neoplasms - pathology</topic><topic>Retrospective Studies</topic><topic>Science & Technology</topic><topic>Testicular Neoplasms - pathology</topic><topic>Tissue Array Analysis</topic><topic>Vulvar Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ye</creatorcontrib><creatorcontrib>Wang, Yangbin</creatorcontrib><creatorcontrib>Qi, Ruiqun</creatorcontrib><creatorcontrib>Mao, Xiaoyun</creatorcontrib><creatorcontrib>Jin, Feng</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ye</au><au>Wang, Yangbin</au><au>Qi, Ruiqun</au><au>Mao, Xiaoyun</au><au>Jin, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of lipoma preferred partner in mammary and extramammary Paget disease</atitle><jtitle>Medicine (Baltimore)</jtitle><stitle>MEDICINE</stitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-12-18</date><risdate>2020</risdate><volume>99</volume><issue>51</issue><spage>e23443</spage><epage>e23443</epage><pages>e23443-e23443</pages><artnum>23443</artnum><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Backgound: This study aims to identify the expression of lipoma preferred partner (LPP) in Paget disease (PD) and to further understand the pathogenesis of PD. Methods: Tissue microarray was used to evaluate the expression of LPP by immunohistochemistry in 40 PD patients. The results of LPP expression were combined with clinical and histopathological characteristics. Patient files were analyzed retrospectively. Results: Twenty-one cases were mammary Paget disease (MPD) and 19 extramammary Paget disease (EMPD) involving the vulva, scrotum, and penis. LPP was expressed in PD and this expression was significantly greater in MPD versus EMPD (P = .031). The expression of LPP in MPD was significantly related with age (P = .009) and expression of Ki-67 (P = .011). No statistically significant differences were observed in LPP expression as related to sex, body location, and time of PD diagnosis. Conclusions: While LPP is expressed in both MPD and EMPD, the intensity of this expression is greater in MPD. LPP expression is positively correlated with Ki-67 and is more prevalent in middle-aged versus senior MPD patients. Further research is needed to determine its potential role in tumorigenesis and distribution.</abstract><cop>PHILADELPHIA</cop><pub>Lippincott Williams & Wilkins</pub><pmid>33371071</pmid><doi>10.1097/MD.0000000000023443</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1965-5926</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Age Factors Aged Aged, 80 and over Breast Neoplasms - pathology Clinical Trial/Experimental Study Cytoskeletal Proteins - biosynthesis Female General & Internal Medicine Humans Life Sciences & Biomedicine LIM Domain Proteins - biosynthesis Male Medicine, General & Internal Middle Aged Neoplasms - pathology Paget Disease, Extramammary - pathology Paget's Disease, Mammary - pathology Penile Neoplasms - pathology Retrospective Studies Science & Technology Testicular Neoplasms - pathology Tissue Array Analysis Vulvar Neoplasms - pathology |
| title | Expression of lipoma preferred partner in mammary and extramammary Paget disease |
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