Glucocorticoid-induced Elevations of C -Esterase Inhibitor: A Mechanism for Protection Against Lethal Dose Range Contrast Challenge in Rabbits

Glucocorticoid-induced Elevations of C -Esterase Inhibitor: A Mechanism for Protection Against Lethal Dose Range Contrast Challenge in Rabbits

Rabbits pretreated with methylprednisolone acquired significant protection against an intravenous challenge of meglumine iodipamide. In comparison to controls, the pretreated rabbits showed moderate elevations of Factor XII, and rather striking elevations of C -esterase inhibitor. Treated rabbits al...

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Veröffentlicht in:Investigative radiology 1981-01, Vol.16 (1), p.20-23
Hauptverfasser: LASSER, ELLIOTT C, LANG, JOSEPH H, LYON, SANDRA G, HAMBLIN, A ELIZABETH, HOWARD, MITZI
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container_end_page 23
container_issue 1
container_start_page 20
container_title Investigative radiology
container_volume 16
creator LASSER, ELLIOTT C
LANG, JOSEPH H
LYON, SANDRA G
HAMBLIN, A ELIZABETH
HOWARD, MITZI
description Rabbits pretreated with methylprednisolone acquired significant protection against an intravenous challenge of meglumine iodipamide. In comparison to controls, the pretreated rabbits showed moderate elevations of Factor XII, and rather striking elevations of C -esterase inhibitor. Treated rabbits also showed significantly less granulocytosis. It is believed that the protective effect can be ascribed to the modulation of acute phase reactants by increased concentrations of C -esterase inhibitor.
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title Glucocorticoid-induced Elevations of C -Esterase Inhibitor: A Mechanism for Protection Against Lethal Dose Range Contrast Challenge in Rabbits
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