Abstract 10199: Atrial Fibrillation is Associated With Impaired Exercise Capacity and Adverse Prognosis in Heart Failure Patients With Mid-range Ejection Fraction
IntroductionExercise capacity represented by peak oxygen uptake (VO2) is an independent predictor of cardiac event in heart failure (HF) patients with reduced ejection fraction. However, factors associated with impaired peak VO2 has not been fully examined in HF patients with mid-range ejection frac...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A10199-A10199 |
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| creator | Sato, Yu Yoshihisa, Akiomi Hotsuki, Yu Watanabe, Koichiro Kimishima, Yusuke Kiko, Takatoyo Kanno, Yuki Yokokawa, Tetsuro Abe, Satoshi Misaka, Tomofumi Sato, Takamasa Oikawa, Masayoshi Kobayashi, Atsushi Yamaki, Takayoshi Kunii, Hiroyuki Nakazato, Kazuhiko Ishida, Takafumi Takeishi, Yasuchika |
| description | IntroductionExercise capacity represented by peak oxygen uptake (VO2) is an independent predictor of cardiac event in heart failure (HF) patients with reduced ejection fraction. However, factors associated with impaired peak VO2 has not been fully examined in HF patients with mid-range ejection fraction (HFmrEF).Methods and ResultsWe divided hospitalized 128 HFmrEF patients based on peak VO2the control group (peak VO2 ≥14 mL/kg/min, n = 83, 64.8%) and the impaired group (peak VO2 |
| doi_str_mv | 10.1161/circ.140.suppl_1.10199 |
| format | Article |
| fullrecord | <record><control><sourceid>wolterskluwer</sourceid><recordid>TN_cdi_wolterskluwer_health_00003017-201911191-00255</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>00003017-201911191-00255</sourcerecordid><originalsourceid>FETCH-wolterskluwer_health_00003017-201911191-002553</originalsourceid><addsrcrecordid>eNqdT8tOxDAMjBBIlMcvIP9AStLHVuVWrVotByQOSBwrbxq2XkJaJSkLv8OXEha-gINlj62Z8TB2I0Uq5UreKnIqlYVI_TLPppepFLKuT1giy6zgRZnXpywRQtS8yrPsnF14v49wlVdlwr6arQ8OVYAj6w6a4AgNdLR1ZAwGmiyQh8b7SREGPcAzhRHu32YkF1H7oZ0ir2GNMyoKn4B2gGZ41y4uH920s5OPAmRho9EF6JDM4uIpamsb_K_eAw3cod1paPdaHV27n7ficMXOXtB4ff3XL1nRtU_rDT9MJkSXV7MctOtHjSaMfUwmciErnsU8UsbiQmRlmf-T9g1U_2zP</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Abstract 10199: Atrial Fibrillation is Associated With Impaired Exercise Capacity and Adverse Prognosis in Heart Failure Patients With Mid-range Ejection Fraction</title><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Sato, Yu ; Yoshihisa, Akiomi ; Hotsuki, Yu ; Watanabe, Koichiro ; Kimishima, Yusuke ; Kiko, Takatoyo ; Kanno, Yuki ; Yokokawa, Tetsuro ; Abe, Satoshi ; Misaka, Tomofumi ; Sato, Takamasa ; Oikawa, Masayoshi ; Kobayashi, Atsushi ; Yamaki, Takayoshi ; Kunii, Hiroyuki ; Nakazato, Kazuhiko ; Ishida, Takafumi ; Takeishi, Yasuchika</creator><creatorcontrib>Sato, Yu ; Yoshihisa, Akiomi ; Hotsuki, Yu ; Watanabe, Koichiro ; Kimishima, Yusuke ; Kiko, Takatoyo ; Kanno, Yuki ; Yokokawa, Tetsuro ; Abe, Satoshi ; Misaka, Tomofumi ; Sato, Takamasa ; Oikawa, Masayoshi ; Kobayashi, Atsushi ; Yamaki, Takayoshi ; Kunii, Hiroyuki ; Nakazato, Kazuhiko ; Ishida, Takafumi ; Takeishi, Yasuchika</creatorcontrib><description>IntroductionExercise capacity represented by peak oxygen uptake (VO2) is an independent predictor of cardiac event in heart failure (HF) patients with reduced ejection fraction. However, factors associated with impaired peak VO2 has not been fully examined in HF patients with mid-range ejection fraction (HFmrEF).Methods and ResultsWe divided hospitalized 128 HFmrEF patients based on peak VO2the control group (peak VO2 ≥14 mL/kg/min, n = 83, 64.8%) and the impaired group (peak VO2 <14 mL/kg/min, n = 45, 35.2%). The impaired group demonstrated higher cardiac event rate, which was defined as cardiac death or worsening HF, during the post-discharge follow-up period of median 1212 days (Log-Rank P <0.001). The impaired group showed higher age and heart rate, and a higher prevalence of atrial fibrillation (age, 71.0 vs. 63.0 years old, P = 0.002; heart rate, 81.0 vs. 73.0 bpm, P = 0.004; atrial fibrillation, 62.2 vs. 31.3%, P = 0.001). In laboratory data, levels of log-transformed B-type natriuretic peptide (log-BNP), blood urea nitrogen (BUN), and serum creatinine were higher while hemoglobin and serum albumin were lower in the impaired group (log-BNP, 2.52 vs. 2.22, P = 0.005; BUN, 20.0 vs. 18.0 mg/dL, P = 0.019; creatinine, 1.03 vs. 0.93 mg/dL, P = 0.027; hemoglobin, 12.4 vs. 13.9 mg/dL, P = 0.001; albumin, 3.8 vs. 4.1 mg/dL, P = 0.026). The Spearman’s correlation analysis revealed that hemoglobin and albumin positively, while age, heart rate, log-BNP, BUN, and left atrial volume negatively correlated with peak VO2. Multiple logistic regression analysis revealed that atrial fibrillation and heart rate were independent predictors of impaired peak VO2 [atrial fibrillation, hazard ratio (HR) 3.242, 95% confidence interval (CI) 1.194-8.799, P = 0.021; heart rate, HR 1.036, 95% CI 1.008-1.066, P = 0.012].ConclusionsAtrial fibrillation and heart rate were independently correlated with impaired peak VO2, and were associated with adverse prognosis in patients with HFmrEF.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/circ.140.suppl_1.10199</identifier><language>eng</language><publisher>by the American College of Cardiology Foundation and the American Heart Association, Inc</publisher><ispartof>Circulation (New York, N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A10199-A10199</ispartof><rights>2019 by the American College of Cardiology Foundation and the American Heart Association, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Sato, Yu</creatorcontrib><creatorcontrib>Yoshihisa, Akiomi</creatorcontrib><creatorcontrib>Hotsuki, Yu</creatorcontrib><creatorcontrib>Watanabe, Koichiro</creatorcontrib><creatorcontrib>Kimishima, Yusuke</creatorcontrib><creatorcontrib>Kiko, Takatoyo</creatorcontrib><creatorcontrib>Kanno, Yuki</creatorcontrib><creatorcontrib>Yokokawa, Tetsuro</creatorcontrib><creatorcontrib>Abe, Satoshi</creatorcontrib><creatorcontrib>Misaka, Tomofumi</creatorcontrib><creatorcontrib>Sato, Takamasa</creatorcontrib><creatorcontrib>Oikawa, Masayoshi</creatorcontrib><creatorcontrib>Kobayashi, Atsushi</creatorcontrib><creatorcontrib>Yamaki, Takayoshi</creatorcontrib><creatorcontrib>Kunii, Hiroyuki</creatorcontrib><creatorcontrib>Nakazato, Kazuhiko</creatorcontrib><creatorcontrib>Ishida, Takafumi</creatorcontrib><creatorcontrib>Takeishi, Yasuchika</creatorcontrib><title>Abstract 10199: Atrial Fibrillation is Associated With Impaired Exercise Capacity and Adverse Prognosis in Heart Failure Patients With Mid-range Ejection Fraction</title><title>Circulation (New York, N.Y.)</title><description>IntroductionExercise capacity represented by peak oxygen uptake (VO2) is an independent predictor of cardiac event in heart failure (HF) patients with reduced ejection fraction. However, factors associated with impaired peak VO2 has not been fully examined in HF patients with mid-range ejection fraction (HFmrEF).Methods and ResultsWe divided hospitalized 128 HFmrEF patients based on peak VO2the control group (peak VO2 ≥14 mL/kg/min, n = 83, 64.8%) and the impaired group (peak VO2 <14 mL/kg/min, n = 45, 35.2%). The impaired group demonstrated higher cardiac event rate, which was defined as cardiac death or worsening HF, during the post-discharge follow-up period of median 1212 days (Log-Rank P <0.001). The impaired group showed higher age and heart rate, and a higher prevalence of atrial fibrillation (age, 71.0 vs. 63.0 years old, P = 0.002; heart rate, 81.0 vs. 73.0 bpm, P = 0.004; atrial fibrillation, 62.2 vs. 31.3%, P = 0.001). In laboratory data, levels of log-transformed B-type natriuretic peptide (log-BNP), blood urea nitrogen (BUN), and serum creatinine were higher while hemoglobin and serum albumin were lower in the impaired group (log-BNP, 2.52 vs. 2.22, P = 0.005; BUN, 20.0 vs. 18.0 mg/dL, P = 0.019; creatinine, 1.03 vs. 0.93 mg/dL, P = 0.027; hemoglobin, 12.4 vs. 13.9 mg/dL, P = 0.001; albumin, 3.8 vs. 4.1 mg/dL, P = 0.026). The Spearman’s correlation analysis revealed that hemoglobin and albumin positively, while age, heart rate, log-BNP, BUN, and left atrial volume negatively correlated with peak VO2. Multiple logistic regression analysis revealed that atrial fibrillation and heart rate were independent predictors of impaired peak VO2 [atrial fibrillation, hazard ratio (HR) 3.242, 95% confidence interval (CI) 1.194-8.799, P = 0.021; heart rate, HR 1.036, 95% CI 1.008-1.066, P = 0.012].ConclusionsAtrial fibrillation and heart rate were independently correlated with impaired peak VO2, and were associated with adverse prognosis in patients with HFmrEF.</description><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqdT8tOxDAMjBBIlMcvIP9AStLHVuVWrVotByQOSBwrbxq2XkJaJSkLv8OXEha-gINlj62Z8TB2I0Uq5UreKnIqlYVI_TLPppepFLKuT1giy6zgRZnXpywRQtS8yrPsnF14v49wlVdlwr6arQ8OVYAj6w6a4AgNdLR1ZAwGmiyQh8b7SREGPcAzhRHu32YkF1H7oZ0ir2GNMyoKn4B2gGZ41y4uH920s5OPAmRho9EF6JDM4uIpamsb_K_eAw3cod1paPdaHV27n7ficMXOXtB4ff3XL1nRtU_rDT9MJkSXV7MctOtHjSaMfUwmciErnsU8UsbiQmRlmf-T9g1U_2zP</recordid><startdate>20191119</startdate><enddate>20191119</enddate><creator>Sato, Yu</creator><creator>Yoshihisa, Akiomi</creator><creator>Hotsuki, Yu</creator><creator>Watanabe, Koichiro</creator><creator>Kimishima, Yusuke</creator><creator>Kiko, Takatoyo</creator><creator>Kanno, Yuki</creator><creator>Yokokawa, Tetsuro</creator><creator>Abe, Satoshi</creator><creator>Misaka, Tomofumi</creator><creator>Sato, Takamasa</creator><creator>Oikawa, Masayoshi</creator><creator>Kobayashi, Atsushi</creator><creator>Yamaki, Takayoshi</creator><creator>Kunii, Hiroyuki</creator><creator>Nakazato, Kazuhiko</creator><creator>Ishida, Takafumi</creator><creator>Takeishi, Yasuchika</creator><general>by the American College of Cardiology Foundation and the American Heart Association, Inc</general><scope/></search><sort><creationdate>20191119</creationdate><title>Abstract 10199: Atrial Fibrillation is Associated With Impaired Exercise Capacity and Adverse Prognosis in Heart Failure Patients With Mid-range Ejection Fraction</title><author>Sato, Yu ; Yoshihisa, Akiomi ; Hotsuki, Yu ; Watanabe, Koichiro ; Kimishima, Yusuke ; Kiko, Takatoyo ; Kanno, Yuki ; Yokokawa, Tetsuro ; Abe, Satoshi ; Misaka, Tomofumi ; Sato, Takamasa ; Oikawa, Masayoshi ; Kobayashi, Atsushi ; Yamaki, Takayoshi ; Kunii, Hiroyuki ; Nakazato, Kazuhiko ; Ishida, Takafumi ; Takeishi, Yasuchika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-wolterskluwer_health_00003017-201911191-002553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Sato, Yu</creatorcontrib><creatorcontrib>Yoshihisa, Akiomi</creatorcontrib><creatorcontrib>Hotsuki, Yu</creatorcontrib><creatorcontrib>Watanabe, Koichiro</creatorcontrib><creatorcontrib>Kimishima, Yusuke</creatorcontrib><creatorcontrib>Kiko, Takatoyo</creatorcontrib><creatorcontrib>Kanno, Yuki</creatorcontrib><creatorcontrib>Yokokawa, Tetsuro</creatorcontrib><creatorcontrib>Abe, Satoshi</creatorcontrib><creatorcontrib>Misaka, Tomofumi</creatorcontrib><creatorcontrib>Sato, Takamasa</creatorcontrib><creatorcontrib>Oikawa, Masayoshi</creatorcontrib><creatorcontrib>Kobayashi, Atsushi</creatorcontrib><creatorcontrib>Yamaki, Takayoshi</creatorcontrib><creatorcontrib>Kunii, Hiroyuki</creatorcontrib><creatorcontrib>Nakazato, Kazuhiko</creatorcontrib><creatorcontrib>Ishida, Takafumi</creatorcontrib><creatorcontrib>Takeishi, Yasuchika</creatorcontrib><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Yu</au><au>Yoshihisa, Akiomi</au><au>Hotsuki, Yu</au><au>Watanabe, Koichiro</au><au>Kimishima, Yusuke</au><au>Kiko, Takatoyo</au><au>Kanno, Yuki</au><au>Yokokawa, Tetsuro</au><au>Abe, Satoshi</au><au>Misaka, Tomofumi</au><au>Sato, Takamasa</au><au>Oikawa, Masayoshi</au><au>Kobayashi, Atsushi</au><au>Yamaki, Takayoshi</au><au>Kunii, Hiroyuki</au><au>Nakazato, Kazuhiko</au><au>Ishida, Takafumi</au><au>Takeishi, Yasuchika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abstract 10199: Atrial Fibrillation is Associated With Impaired Exercise Capacity and Adverse Prognosis in Heart Failure Patients With Mid-range Ejection Fraction</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><date>2019-11-19</date><risdate>2019</risdate><volume>140</volume><issue>Suppl_1 Suppl 1</issue><spage>A10199</spage><epage>A10199</epage><pages>A10199-A10199</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>IntroductionExercise capacity represented by peak oxygen uptake (VO2) is an independent predictor of cardiac event in heart failure (HF) patients with reduced ejection fraction. However, factors associated with impaired peak VO2 has not been fully examined in HF patients with mid-range ejection fraction (HFmrEF).Methods and ResultsWe divided hospitalized 128 HFmrEF patients based on peak VO2the control group (peak VO2 ≥14 mL/kg/min, n = 83, 64.8%) and the impaired group (peak VO2 <14 mL/kg/min, n = 45, 35.2%). The impaired group demonstrated higher cardiac event rate, which was defined as cardiac death or worsening HF, during the post-discharge follow-up period of median 1212 days (Log-Rank P <0.001). The impaired group showed higher age and heart rate, and a higher prevalence of atrial fibrillation (age, 71.0 vs. 63.0 years old, P = 0.002; heart rate, 81.0 vs. 73.0 bpm, P = 0.004; atrial fibrillation, 62.2 vs. 31.3%, P = 0.001). In laboratory data, levels of log-transformed B-type natriuretic peptide (log-BNP), blood urea nitrogen (BUN), and serum creatinine were higher while hemoglobin and serum albumin were lower in the impaired group (log-BNP, 2.52 vs. 2.22, P = 0.005; BUN, 20.0 vs. 18.0 mg/dL, P = 0.019; creatinine, 1.03 vs. 0.93 mg/dL, P = 0.027; hemoglobin, 12.4 vs. 13.9 mg/dL, P = 0.001; albumin, 3.8 vs. 4.1 mg/dL, P = 0.026). The Spearman’s correlation analysis revealed that hemoglobin and albumin positively, while age, heart rate, log-BNP, BUN, and left atrial volume negatively correlated with peak VO2. Multiple logistic regression analysis revealed that atrial fibrillation and heart rate were independent predictors of impaired peak VO2 [atrial fibrillation, hazard ratio (HR) 3.242, 95% confidence interval (CI) 1.194-8.799, P = 0.021; heart rate, HR 1.036, 95% CI 1.008-1.066, P = 0.012].ConclusionsAtrial fibrillation and heart rate were independently correlated with impaired peak VO2, and were associated with adverse prognosis in patients with HFmrEF.</abstract><pub>by the American College of Cardiology Foundation and the American Heart Association, Inc</pub><doi>10.1161/circ.140.suppl_1.10199</doi></addata></record> |
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| title | Abstract 10199: Atrial Fibrillation is Associated With Impaired Exercise Capacity and Adverse Prognosis in Heart Failure Patients With Mid-range Ejection Fraction |
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