Abstract 13326: Left Ventricular Mechanical Dispersion and Markers of Subclinical Myocardial Injury and Dysfunction in the General Population

IntroductionMechanical dispersion quantitates left ventricular (LV) contraction heterogeneity and has been found associated with sudden cardiac death. Accordingly, we hypothesized that mechanical dispersion would be associated with markers of subclinical myocardial injury and dysfunction in the general population.MethodsWe included 2529 subjects participating in a prospective epidemiologic study of subjects born in 1950 from Akershus County, Norway. Mechanical dispersion was calculated by 2D speckle tracking echocardiography from LV global longitudinal strain (GLS) and is the standard deviation of contraction duration in 16 segments. We measured high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations as markers of subclinical myocardial injury and dysfunction, respectively.ResultsMedian age was 64 (IQR 63.5-64.5) years with 49.8% women, 59% had hypertension and 5.9% had coronary artery disease. Median mechanical dispersion value was 38.0 (29.75-47.00) ms, median hs-cTnT concentration was 6.0 (4.0-8.0) ng/L and median NT-proBNP concentration was 54.0 (33.8-93.0) ng/L. hs-cTnT correlated with mechanical dispersion (rho=0.084, p