The Bupivacaine Story: A Tribute to George A. Albright, MD (1931–2020)

In 1979, George A. Albright, MD (1931–2020) published a controversial editorial in Anesthesiology that raised the question of bupivacaine cardiotoxicity. In it, he presented several cases of rapid cardiovascular collapse after administration of the highly lipophilic local anesthetic and called for f...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Anesthesia and analgesia 2022-08
Hauptverfasser: Larson, C. Philip, Youssefzadeh, Kevin, Moon, Jane S.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title Anesthesia and analgesia
container_volume
creator Larson, C. Philip
Youssefzadeh, Kevin
Moon, Jane S.
description In 1979, George A. Albright, MD (1931–2020) published a controversial editorial in Anesthesiology that raised the question of bupivacaine cardiotoxicity. In it, he presented several cases of rapid cardiovascular collapse after administration of the highly lipophilic local anesthetic and called for further investigation. Although the scientific community initially resisted Dr Albright’s idea, his editorial would ultimately lead to several important advancements in anesthesiology. In 1983, the US Food and Drug Administration issued a black box warning that recommended against the use of 0.75% bupivacaine in obstetric anesthesia. This warning would remain in place until 1999. In addition, Dr Albright’s article led to the following changeslaboratory research that proved the cardiotoxicity of bupivacaine; the development of safer, stereoselective agents like ropivacaine; and the acceptance of lipid emulsion as a treatment for local anesthetic toxicity. In this article, C. Philip Larson, Jr, MDCM, Editor-in-Chief of Anesthesiology at the time of publication of Albright’s manuscript, provides a unique perspective on the bupivacaine story.
doi_str_mv 10.1213/ANE.0000000000006161
format Article
fullrecord <record><control><sourceid>wolterskluwer</sourceid><recordid>TN_cdi_wolterskluwer_health_00000539-990000000-00402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>00000539-990000000-00402</sourcerecordid><originalsourceid>FETCH-wolterskluwer_health_00000539-990000000-004023</originalsourceid><addsrcrecordid>eNqdjjsOgkAURafQxO8OLF6pieB8lDh2qCiNNtIbNE9AJ2KGQWLnHtyhK5EYCmtvc-8pbnII6TFqM87EyN16Nv2JwxxWI81yCYtLKRuklWXnEhmdOk3iBzHCPL8l9_AYJleEnUn1YwYuBDo55AbBpLDGVEcIrg2uOugkis0QNkvoMynY-_nilNNBh9RPocqwW3WbjFdesPCtIlUGdXZReYF6H2OoTLz_qk2EtKSsPC1Kx5SLP28fnaJFmw</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The Bupivacaine Story: A Tribute to George A. Albright, MD (1931–2020)</title><source>Journals@Ovid LWW Legacy Archive</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Larson, C. Philip ; Youssefzadeh, Kevin ; Moon, Jane S.</creator><creatorcontrib>Larson, C. Philip ; Youssefzadeh, Kevin ; Moon, Jane S.</creatorcontrib><description>In 1979, George A. Albright, MD (1931–2020) published a controversial editorial in Anesthesiology that raised the question of bupivacaine cardiotoxicity. In it, he presented several cases of rapid cardiovascular collapse after administration of the highly lipophilic local anesthetic and called for further investigation. Although the scientific community initially resisted Dr Albright’s idea, his editorial would ultimately lead to several important advancements in anesthesiology. In 1983, the US Food and Drug Administration issued a black box warning that recommended against the use of 0.75% bupivacaine in obstetric anesthesia. This warning would remain in place until 1999. In addition, Dr Albright’s article led to the following changeslaboratory research that proved the cardiotoxicity of bupivacaine; the development of safer, stereoselective agents like ropivacaine; and the acceptance of lipid emulsion as a treatment for local anesthetic toxicity. In this article, C. Philip Larson, Jr, MDCM, Editor-in-Chief of Anesthesiology at the time of publication of Albright’s manuscript, provides a unique perspective on the bupivacaine story.</description><identifier>ISSN: 0003-2999</identifier><identifier>DOI: 10.1213/ANE.0000000000006161</identifier><language>eng</language><publisher>Lippincott Williams &amp; Wilkin</publisher><ispartof>Anesthesia and analgesia, 2022-08</ispartof><rights>Lippincott Williams &amp; Wilkin</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00000539-990000000-00402$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;NEWS=n&amp;CSC=Y&amp;PAGE=fulltext&amp;D=ovft&amp;AN=00000539-990000000-00402$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>315,782,786,4611,27931,27932,64673,65468</link.rule.ids></links><search><creatorcontrib>Larson, C. Philip</creatorcontrib><creatorcontrib>Youssefzadeh, Kevin</creatorcontrib><creatorcontrib>Moon, Jane S.</creatorcontrib><title>The Bupivacaine Story: A Tribute to George A. Albright, MD (1931–2020)</title><title>Anesthesia and analgesia</title><description>In 1979, George A. Albright, MD (1931–2020) published a controversial editorial in Anesthesiology that raised the question of bupivacaine cardiotoxicity. In it, he presented several cases of rapid cardiovascular collapse after administration of the highly lipophilic local anesthetic and called for further investigation. Although the scientific community initially resisted Dr Albright’s idea, his editorial would ultimately lead to several important advancements in anesthesiology. In 1983, the US Food and Drug Administration issued a black box warning that recommended against the use of 0.75% bupivacaine in obstetric anesthesia. This warning would remain in place until 1999. In addition, Dr Albright’s article led to the following changeslaboratory research that proved the cardiotoxicity of bupivacaine; the development of safer, stereoselective agents like ropivacaine; and the acceptance of lipid emulsion as a treatment for local anesthetic toxicity. In this article, C. Philip Larson, Jr, MDCM, Editor-in-Chief of Anesthesiology at the time of publication of Albright’s manuscript, provides a unique perspective on the bupivacaine story.</description><issn>0003-2999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqdjjsOgkAURafQxO8OLF6pieB8lDh2qCiNNtIbNE9AJ2KGQWLnHtyhK5EYCmtvc-8pbnII6TFqM87EyN16Nv2JwxxWI81yCYtLKRuklWXnEhmdOk3iBzHCPL8l9_AYJleEnUn1YwYuBDo55AbBpLDGVEcIrg2uOugkis0QNkvoMynY-_nilNNBh9RPocqwW3WbjFdesPCtIlUGdXZReYF6H2OoTLz_qk2EtKSsPC1Kx5SLP28fnaJFmw</recordid><startdate>20220803</startdate><enddate>20220803</enddate><creator>Larson, C. Philip</creator><creator>Youssefzadeh, Kevin</creator><creator>Moon, Jane S.</creator><general>Lippincott Williams &amp; Wilkin</general><scope/></search><sort><creationdate>20220803</creationdate><title>The Bupivacaine Story: A Tribute to George A. Albright, MD (1931–2020)</title><author>Larson, C. Philip ; Youssefzadeh, Kevin ; Moon, Jane S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-wolterskluwer_health_00000539-990000000-004023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Larson, C. Philip</creatorcontrib><creatorcontrib>Youssefzadeh, Kevin</creatorcontrib><creatorcontrib>Moon, Jane S.</creatorcontrib><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Larson, C. Philip</au><au>Youssefzadeh, Kevin</au><au>Moon, Jane S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Bupivacaine Story: A Tribute to George A. Albright, MD (1931–2020)</atitle><jtitle>Anesthesia and analgesia</jtitle><date>2022-08-03</date><risdate>2022</risdate><issn>0003-2999</issn><abstract>In 1979, George A. Albright, MD (1931–2020) published a controversial editorial in Anesthesiology that raised the question of bupivacaine cardiotoxicity. In it, he presented several cases of rapid cardiovascular collapse after administration of the highly lipophilic local anesthetic and called for further investigation. Although the scientific community initially resisted Dr Albright’s idea, his editorial would ultimately lead to several important advancements in anesthesiology. In 1983, the US Food and Drug Administration issued a black box warning that recommended against the use of 0.75% bupivacaine in obstetric anesthesia. This warning would remain in place until 1999. In addition, Dr Albright’s article led to the following changeslaboratory research that proved the cardiotoxicity of bupivacaine; the development of safer, stereoselective agents like ropivacaine; and the acceptance of lipid emulsion as a treatment for local anesthetic toxicity. In this article, C. Philip Larson, Jr, MDCM, Editor-in-Chief of Anesthesiology at the time of publication of Albright’s manuscript, provides a unique perspective on the bupivacaine story.</abstract><pub>Lippincott Williams &amp; Wilkin</pub><doi>10.1213/ANE.0000000000006161</doi></addata></record>
fulltext fulltext
identifier ISSN: 0003-2999
ispartof Anesthesia and analgesia, 2022-08
issn 0003-2999
language eng
recordid cdi_wolterskluwer_health_00000539-990000000-00402
source Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
title The Bupivacaine Story: A Tribute to George A. Albright, MD (1931–2020)
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T18%3A56%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wolterskluwer&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Bupivacaine%20Story:%20A%20Tribute%20to%20George%20A.%20Albright,%20MD%20(1931%E2%80%932020)&rft.jtitle=Anesthesia%20and%20analgesia&rft.au=Larson,%20C.%20Philip&rft.date=2022-08-03&rft.issn=0003-2999&rft_id=info:doi/10.1213/ANE.0000000000006161&rft_dat=%3Cwolterskluwer%3E00000539-990000000-00402%3C/wolterskluwer%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true