CRMP2 mediates Sema3F‐dependent axon pruning and dendritic spine remodeling

Regulation of axon guidance and pruning of inappropriate synapses by class 3 semaphorins are key to the development of neural circuits. Collapsin response mediator protein 2 (CRMP2) has been shown to regulate axon guidance by mediating semaphorin 3A (Sema3A) signaling; however, nothing is known abou...

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Veröffentlicht in:	EMBO reports 2020-03, Vol.21 (3), p.e48512-n/a
Hauptverfasser:	Ziak, Jakub, Weissova, Romana, Jeřábková, Kateřina, Janikova, Martina, Maimon, Roy, Petrasek, Tomas, Pukajova, Barbora, Kleisnerova, Marie, Wang, Mengzhe, Brill, Monika S, Kasparek, Petr, Zhou, Xunlei, Alvarez‐Bolado, Gonzalo, Sedlacek, Radislav, Misgeld, Thomas, Stuchlik, Ales, Perlson, Eran, Balastik, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Animals Autism Autism Spectrum Disorder Axon guidance Behavior Collapsin response mediator protein 2 Corpus callosum Defects Dendritic Spines Dendritic structure EMBO05 EMBO27 Intercellular Signaling Peptides and Proteins - genetics Mediator protein Membrane Proteins - physiology Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neural networks Neuronal Plasticity Neurons Peripheral nerves Pruning Semaphorins Signal Transduction Signaling Social behavior Spine synapse pruning Synapses Visual cortex Visual pathways
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