Subglottic Squamous Cell Carcinoma
Objective Subglottic squamous cell carcinoma (SCCa) is a rare malignancy representing
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2016-02, Vol.154 (2), p.315-321 |
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| container_title | Otolaryngology-head and neck surgery |
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| creator | Marchiano, Emily Patel, Dhruv M. Patel, Tapan D. Patel, Amit A. Xue, Yuhan E. Eloy, Jean Anderson Baredes, Soly Park, Richard Chan W. |
| description | Objective
Subglottic squamous cell carcinoma (SCCa) is a rare malignancy representing |
| doi_str_mv | 10.1177/0194599815618190 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley</sourceid><recordid>TN_cdi_wiley_primary_10_1177_0194599815618190_OHNBF07601</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>OHNBF07601</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2321-b0e873db8c1f0319c8edfa8c707e6291af5d99926c09d12e88e1fbc19a7260cc3</originalsourceid><addsrcrecordid>eNpdj0FLwzAYQIM4sG7ePRbv0e9LbL58Ry3OCcMdpueQpolUWqvtiuzfS9GTp3d48OAJcYlwjUh0A8i3BbPFwqBFhhORITBJY5FORTZrOfszcT6O7wBgDFEmrvZT9db2h0MT8v3X5Lt-GvMytm1e-iE0H33nV2KRfDvGiz8uxev64aXcyO3u8am828qgtEJZQbSk68oGTKCRg4118jYQUDSK0aeiZmZlAnCNKlobMVUB2ZMyEIJeCvvb_W7aeHSfQ9P54egQ3Dzo_g-63eb5fg1kAPUPnihEcQ</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Subglottic Squamous Cell Carcinoma</title><source>SAGE Journals【Remote access NOT available】</source><source>Wiley Blackwell Journals</source><creator>Marchiano, Emily ; Patel, Dhruv M. ; Patel, Tapan D. ; Patel, Amit A. ; Xue, Yuhan E. ; Eloy, Jean Anderson ; Baredes, Soly ; Park, Richard Chan W.</creator><creatorcontrib>Marchiano, Emily ; Patel, Dhruv M. ; Patel, Tapan D. ; Patel, Amit A. ; Xue, Yuhan E. ; Eloy, Jean Anderson ; Baredes, Soly ; Park, Richard Chan W.</creatorcontrib><description>Objective
Subglottic squamous cell carcinoma (SCCa) is a rare malignancy representing <5% of all laryngeal cancers. Patients often present with late‐stage disease, and survival outcomes are reportedly worse than those for SCCa in other regions of the larynx.
Study Design
Analysis of a population‐based tumor registry.
Setting
Academic medical center.
Subjects and Methods
The US National Cancer Institute’s Surveillance, Epidemiology, and End Results database was queried for cases of subglottic SCCa from 1973 to 2011 (889 cases). Resulting data were analyzed, including patient demographics, therapeutic measures, and survival outcomes.
Results
Subglottic SCCa most frequently occurred in the fifth to seventh decade of life, with a mean age at diagnosis of 65.7 ± 11.3 years. There was a strong male predilection, with a male:female ratio of 3.83:1. Most patients were stage III and IV (64.4%) per the American Joint Committee on Cancer. The most common treatment modality was a combination of radiotherapy and surgery (38.8%), followed by radiotherapy alone (33.9%), and surgery alone (17.0%). Overall 5‐year disease‐specific survival rate was 53.7%. When stratified by treatment modality, 5‐year disease‐specific survival was 62.4% for surgery alone, 56.7% for radiotherapy alone, and 55.1% for surgery with adjuvant radiotherapy (P =. 3892).
Conclusion
This study represents the largest cohort of subglottic SCCa. It shows a strong predilection for men in the US population. Surgery with adjuvant radiotherapy was the most commonly employed treatment modality. No statistically significant differences were observed in 5‐year DSS by treatment modality.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1177/0194599815618190</identifier><language>eng</language><publisher>Sage CA: Los Angeles, CA: SAGE Publications</publisher><subject>cancer ; demographic ; disease‐specific survival ; laryngeal ; malignancy ; relative survival ; SEER ; squamous cell carcinoma of the subglottis ; subglottic ; subglottic squamous cell carcinoma</subject><ispartof>Otolaryngology-head and neck surgery, 2016-02, Vol.154 (2), p.315-321</ispartof><rights>2016 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2321-b0e873db8c1f0319c8edfa8c707e6291af5d99926c09d12e88e1fbc19a7260cc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1177%2F0194599815618190$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1177%2F0194599815618190$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Marchiano, Emily</creatorcontrib><creatorcontrib>Patel, Dhruv M.</creatorcontrib><creatorcontrib>Patel, Tapan D.</creatorcontrib><creatorcontrib>Patel, Amit A.</creatorcontrib><creatorcontrib>Xue, Yuhan E.</creatorcontrib><creatorcontrib>Eloy, Jean Anderson</creatorcontrib><creatorcontrib>Baredes, Soly</creatorcontrib><creatorcontrib>Park, Richard Chan W.</creatorcontrib><title>Subglottic Squamous Cell Carcinoma</title><title>Otolaryngology-head and neck surgery</title><description>Objective
Subglottic squamous cell carcinoma (SCCa) is a rare malignancy representing <5% of all laryngeal cancers. Patients often present with late‐stage disease, and survival outcomes are reportedly worse than those for SCCa in other regions of the larynx.
Study Design
Analysis of a population‐based tumor registry.
Setting
Academic medical center.
Subjects and Methods
The US National Cancer Institute’s Surveillance, Epidemiology, and End Results database was queried for cases of subglottic SCCa from 1973 to 2011 (889 cases). Resulting data were analyzed, including patient demographics, therapeutic measures, and survival outcomes.
Results
Subglottic SCCa most frequently occurred in the fifth to seventh decade of life, with a mean age at diagnosis of 65.7 ± 11.3 years. There was a strong male predilection, with a male:female ratio of 3.83:1. Most patients were stage III and IV (64.4%) per the American Joint Committee on Cancer. The most common treatment modality was a combination of radiotherapy and surgery (38.8%), followed by radiotherapy alone (33.9%), and surgery alone (17.0%). Overall 5‐year disease‐specific survival rate was 53.7%. When stratified by treatment modality, 5‐year disease‐specific survival was 62.4% for surgery alone, 56.7% for radiotherapy alone, and 55.1% for surgery with adjuvant radiotherapy (P =. 3892).
Conclusion
This study represents the largest cohort of subglottic SCCa. It shows a strong predilection for men in the US population. Surgery with adjuvant radiotherapy was the most commonly employed treatment modality. No statistically significant differences were observed in 5‐year DSS by treatment modality.</description><subject>cancer</subject><subject>demographic</subject><subject>disease‐specific survival</subject><subject>laryngeal</subject><subject>malignancy</subject><subject>relative survival</subject><subject>SEER</subject><subject>squamous cell carcinoma of the subglottis</subject><subject>subglottic</subject><subject>subglottic squamous cell carcinoma</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNpdj0FLwzAYQIM4sG7ePRbv0e9LbL58Ry3OCcMdpueQpolUWqvtiuzfS9GTp3d48OAJcYlwjUh0A8i3BbPFwqBFhhORITBJY5FORTZrOfszcT6O7wBgDFEmrvZT9db2h0MT8v3X5Lt-GvMytm1e-iE0H33nV2KRfDvGiz8uxev64aXcyO3u8am828qgtEJZQbSk68oGTKCRg4118jYQUDSK0aeiZmZlAnCNKlobMVUB2ZMyEIJeCvvb_W7aeHSfQ9P54egQ3Dzo_g-63eb5fg1kAPUPnihEcQ</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Marchiano, Emily</creator><creator>Patel, Dhruv M.</creator><creator>Patel, Tapan D.</creator><creator>Patel, Amit A.</creator><creator>Xue, Yuhan E.</creator><creator>Eloy, Jean Anderson</creator><creator>Baredes, Soly</creator><creator>Park, Richard Chan W.</creator><general>SAGE Publications</general><scope/></search><sort><creationdate>201602</creationdate><title>Subglottic Squamous Cell Carcinoma</title><author>Marchiano, Emily ; Patel, Dhruv M. ; Patel, Tapan D. ; Patel, Amit A. ; Xue, Yuhan E. ; Eloy, Jean Anderson ; Baredes, Soly ; Park, Richard Chan W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2321-b0e873db8c1f0319c8edfa8c707e6291af5d99926c09d12e88e1fbc19a7260cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>cancer</topic><topic>demographic</topic><topic>disease‐specific survival</topic><topic>laryngeal</topic><topic>malignancy</topic><topic>relative survival</topic><topic>SEER</topic><topic>squamous cell carcinoma of the subglottis</topic><topic>subglottic</topic><topic>subglottic squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marchiano, Emily</creatorcontrib><creatorcontrib>Patel, Dhruv M.</creatorcontrib><creatorcontrib>Patel, Tapan D.</creatorcontrib><creatorcontrib>Patel, Amit A.</creatorcontrib><creatorcontrib>Xue, Yuhan E.</creatorcontrib><creatorcontrib>Eloy, Jean Anderson</creatorcontrib><creatorcontrib>Baredes, Soly</creatorcontrib><creatorcontrib>Park, Richard Chan W.</creatorcontrib><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marchiano, Emily</au><au>Patel, Dhruv M.</au><au>Patel, Tapan D.</au><au>Patel, Amit A.</au><au>Xue, Yuhan E.</au><au>Eloy, Jean Anderson</au><au>Baredes, Soly</au><au>Park, Richard Chan W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subglottic Squamous Cell Carcinoma</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><date>2016-02</date><risdate>2016</risdate><volume>154</volume><issue>2</issue><spage>315</spage><epage>321</epage><pages>315-321</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Objective
Subglottic squamous cell carcinoma (SCCa) is a rare malignancy representing <5% of all laryngeal cancers. Patients often present with late‐stage disease, and survival outcomes are reportedly worse than those for SCCa in other regions of the larynx.
Study Design
Analysis of a population‐based tumor registry.
Setting
Academic medical center.
Subjects and Methods
The US National Cancer Institute’s Surveillance, Epidemiology, and End Results database was queried for cases of subglottic SCCa from 1973 to 2011 (889 cases). Resulting data were analyzed, including patient demographics, therapeutic measures, and survival outcomes.
Results
Subglottic SCCa most frequently occurred in the fifth to seventh decade of life, with a mean age at diagnosis of 65.7 ± 11.3 years. There was a strong male predilection, with a male:female ratio of 3.83:1. Most patients were stage III and IV (64.4%) per the American Joint Committee on Cancer. The most common treatment modality was a combination of radiotherapy and surgery (38.8%), followed by radiotherapy alone (33.9%), and surgery alone (17.0%). Overall 5‐year disease‐specific survival rate was 53.7%. When stratified by treatment modality, 5‐year disease‐specific survival was 62.4% for surgery alone, 56.7% for radiotherapy alone, and 55.1% for surgery with adjuvant radiotherapy (P =. 3892).
Conclusion
This study represents the largest cohort of subglottic SCCa. It shows a strong predilection for men in the US population. Surgery with adjuvant radiotherapy was the most commonly employed treatment modality. No statistically significant differences were observed in 5‐year DSS by treatment modality.</abstract><cop>Sage CA: Los Angeles, CA</cop><pub>SAGE Publications</pub><doi>10.1177/0194599815618190</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0194-5998 |
| ispartof | Otolaryngology-head and neck surgery, 2016-02, Vol.154 (2), p.315-321 |
| issn | 0194-5998 1097-6817 |
| language | eng |
| recordid | cdi_wiley_primary_10_1177_0194599815618190_OHNBF07601 |
| source | SAGE Journals【Remote access NOT available】; Wiley Blackwell Journals |
| subjects | cancer demographic disease‐specific survival laryngeal malignancy relative survival SEER squamous cell carcinoma of the subglottis subglottic subglottic squamous cell carcinoma |
| title | Subglottic Squamous Cell Carcinoma |
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