Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography
Photoacoustic imaging (PAI) is a noninvasive, nonionizing modality based on the differences in light absorption of various biological tissues. PAI utilizes the endogenous contrast characteristics of traditional optical imaging, while benefiting from high spatial resolution of the ultrasound imaging....
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| Veröffentlicht in: | Medical physics (Lancaster) 2007-08, Vol.34 (8), p.3294-3301 |
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| creator | Yang, Sihua Xing, Da Zhou, Quan Xiang, Liangzhong Lao, Yeqi |
| description | Photoacoustic imaging (PAI) is a noninvasive, nonionizing modality based on the differences in light absorption of various biological tissues. PAI utilizes the endogenous contrast characteristics of traditional optical imaging, while benefiting from high spatial resolution of the ultrasound imaging. A PAI system was developed to reconstruct the two-dimensional cross section image and to visualize the cerebrovascular activities of mouse in vivo. The spatial resolution of the PAI system was determined to be
0.110
mm
by a two-point-source phantom with the Rayleigh criterion. The potential applications of the system were clearly demonstrated by successfully mapping a traumatic lesion in the mouse brain cerebral cortex, by its ability to monitor physiological changes in the brain due to carotid ligation and drug stimulation, and two-dimensional sliced images of a traumatic mouse brain at different depths were also provided. Our experimental results indicate that PAI has the potential for studying of traumatic brain injury and physiological functions of the brain. |
| doi_str_mv | 10.1118/1.2757088 |
| format | Article |
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0.110
mm
by a two-point-source phantom with the Rayleigh criterion. The potential applications of the system were clearly demonstrated by successfully mapping a traumatic lesion in the mouse brain cerebral cortex, by its ability to monitor physiological changes in the brain due to carotid ligation and drug stimulation, and two-dimensional sliced images of a traumatic mouse brain at different depths were also provided. Our experimental results indicate that PAI has the potential for studying of traumatic brain injury and physiological functions of the brain.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1118/1.2757088</identifier><identifier>PMID: 17879793</identifier><identifier>CODEN: MPHYA6</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>Acoustics ; Algorithms ; Animals ; biological tissues ; biomedical imaging ; brain ; Brain - pathology ; Brain Injuries - diagnostic imaging ; Brain Injuries - pathology ; brain vascular ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - pathology ; Cerebrovascular Circulation ; drug stimulation ; drugs ; Functional monitoring and imaging ; Haemodynamics ; Image Processing, Computer-Assisted ; image reconstruction ; Ischemia - pathology ; Medical image reconstruction ; Medical imaging ; Mice ; Models, Statistical ; Non‐ionizing radiation equipment and techniques ; Optical absorption ; optical tomography ; Phantoms, Imaging ; photoacoustic effect ; photoacoustic imaging ; photoacoustic signal ; Spatial resolution ; Spectroscopic and microscopic techniques in biophysics and medical physics ; Tissues ; Tomography - instrumentation ; Tomography - methods ; Tomography, X-Ray Computed - methods ; traumatic lesion</subject><ispartof>Medical physics (Lancaster), 2007-08, Vol.34 (8), p.3294-3301</ispartof><rights>American Association of Physicists in Medicine</rights><rights>2007 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5128-766e47839b071673bccfc3a96872c931a2ac33bfc21949d63790b0e3f0b1ab0c3</citedby><cites>FETCH-LOGICAL-c5128-766e47839b071673bccfc3a96872c931a2ac33bfc21949d63790b0e3f0b1ab0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1118%2F1.2757088$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.2757088$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17879793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Sihua</creatorcontrib><creatorcontrib>Xing, Da</creatorcontrib><creatorcontrib>Zhou, Quan</creatorcontrib><creatorcontrib>Xiang, Liangzhong</creatorcontrib><creatorcontrib>Lao, Yeqi</creatorcontrib><title>Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>Photoacoustic imaging (PAI) is a noninvasive, nonionizing modality based on the differences in light absorption of various biological tissues. PAI utilizes the endogenous contrast characteristics of traditional optical imaging, while benefiting from high spatial resolution of the ultrasound imaging. A PAI system was developed to reconstruct the two-dimensional cross section image and to visualize the cerebrovascular activities of mouse in vivo. The spatial resolution of the PAI system was determined to be
0.110
mm
by a two-point-source phantom with the Rayleigh criterion. The potential applications of the system were clearly demonstrated by successfully mapping a traumatic lesion in the mouse brain cerebral cortex, by its ability to monitor physiological changes in the brain due to carotid ligation and drug stimulation, and two-dimensional sliced images of a traumatic mouse brain at different depths were also provided. Our experimental results indicate that PAI has the potential for studying of traumatic brain injury and physiological functions of the brain.</description><subject>Acoustics</subject><subject>Algorithms</subject><subject>Animals</subject><subject>biological tissues</subject><subject>biomedical imaging</subject><subject>brain</subject><subject>Brain - pathology</subject><subject>Brain Injuries - diagnostic imaging</subject><subject>Brain Injuries - pathology</subject><subject>brain vascular</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebrovascular Circulation</subject><subject>drug stimulation</subject><subject>drugs</subject><subject>Functional monitoring and imaging</subject><subject>Haemodynamics</subject><subject>Image Processing, Computer-Assisted</subject><subject>image reconstruction</subject><subject>Ischemia - pathology</subject><subject>Medical image reconstruction</subject><subject>Medical imaging</subject><subject>Mice</subject><subject>Models, Statistical</subject><subject>Non‐ionizing radiation equipment and techniques</subject><subject>Optical absorption</subject><subject>optical tomography</subject><subject>Phantoms, Imaging</subject><subject>photoacoustic effect</subject><subject>photoacoustic imaging</subject><subject>photoacoustic signal</subject><subject>Spatial resolution</subject><subject>Spectroscopic and microscopic techniques in biophysics and medical physics</subject><subject>Tissues</subject><subject>Tomography - instrumentation</subject><subject>Tomography - methods</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>traumatic lesion</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctKxDAUhoMoOl4WvoBkJShUc2mbZCOIeANFF7oOaSadiaRNTdqReXszTEFBxlU23_-dnP8AcIzRBcaYX-ILwgqGON8CE5IzmuUEiW0wQUjkGclRsQf2Y_xACJW0QLtgDzPOBBN0Arq7odW99a1y0DZqZtsZ9DXUJpgq-IWKenAqQJWYhe2tidC2MDbKOajaFHARDnEVmtvZPAsmejesdLCb-94r7YfYWw173_hZUN18eQh26pQyR-N7AN7vbt9uHrKnl_vHm-unTBeY8IyVpckZp6JCDJeMVlrXmipRcka0oFgRpSmtak2wyMW0pEygChlaowqrCml6AE7X3i74z8HEXjY2auOcak36lCw54YznRQLP1qAOPsZgatmFtFhYSozkql6J5VhvYk9G6VA1ZvpDjn0mIFsDX9aZ5WaTfH4dhVdrPmrbq1VxmzM_l5LjpaRPgvNNgoUPvwZ20_o_-O-u3-HXtuw</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Yang, Sihua</creator><creator>Xing, Da</creator><creator>Zhou, Quan</creator><creator>Xiang, Liangzhong</creator><creator>Lao, Yeqi</creator><general>American Association of Physicists in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography</title><author>Yang, Sihua ; Xing, Da ; Zhou, Quan ; Xiang, Liangzhong ; Lao, Yeqi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5128-766e47839b071673bccfc3a96872c931a2ac33bfc21949d63790b0e3f0b1ab0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acoustics</topic><topic>Algorithms</topic><topic>Animals</topic><topic>biological tissues</topic><topic>biomedical imaging</topic><topic>brain</topic><topic>Brain - pathology</topic><topic>Brain Injuries - diagnostic imaging</topic><topic>Brain Injuries - pathology</topic><topic>brain vascular</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - pathology</topic><topic>Cerebrovascular Circulation</topic><topic>drug stimulation</topic><topic>drugs</topic><topic>Functional monitoring and imaging</topic><topic>Haemodynamics</topic><topic>Image Processing, Computer-Assisted</topic><topic>image reconstruction</topic><topic>Ischemia - pathology</topic><topic>Medical image reconstruction</topic><topic>Medical imaging</topic><topic>Mice</topic><topic>Models, Statistical</topic><topic>Non‐ionizing radiation equipment and techniques</topic><topic>Optical absorption</topic><topic>optical tomography</topic><topic>Phantoms, Imaging</topic><topic>photoacoustic effect</topic><topic>photoacoustic imaging</topic><topic>photoacoustic signal</topic><topic>Spatial resolution</topic><topic>Spectroscopic and microscopic techniques in biophysics and medical physics</topic><topic>Tissues</topic><topic>Tomography - instrumentation</topic><topic>Tomography - methods</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>traumatic lesion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Sihua</creatorcontrib><creatorcontrib>Xing, Da</creatorcontrib><creatorcontrib>Zhou, Quan</creatorcontrib><creatorcontrib>Xiang, Liangzhong</creatorcontrib><creatorcontrib>Lao, Yeqi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Sihua</au><au>Xing, Da</au><au>Zhou, Quan</au><au>Xiang, Liangzhong</au><au>Lao, Yeqi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2007-08</date><risdate>2007</risdate><volume>34</volume><issue>8</issue><spage>3294</spage><epage>3301</epage><pages>3294-3301</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><coden>MPHYA6</coden><abstract>Photoacoustic imaging (PAI) is a noninvasive, nonionizing modality based on the differences in light absorption of various biological tissues. PAI utilizes the endogenous contrast characteristics of traditional optical imaging, while benefiting from high spatial resolution of the ultrasound imaging. A PAI system was developed to reconstruct the two-dimensional cross section image and to visualize the cerebrovascular activities of mouse in vivo. The spatial resolution of the PAI system was determined to be
0.110
mm
by a two-point-source phantom with the Rayleigh criterion. The potential applications of the system were clearly demonstrated by successfully mapping a traumatic lesion in the mouse brain cerebral cortex, by its ability to monitor physiological changes in the brain due to carotid ligation and drug stimulation, and two-dimensional sliced images of a traumatic mouse brain at different depths were also provided. Our experimental results indicate that PAI has the potential for studying of traumatic brain injury and physiological functions of the brain.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><pmid>17879793</pmid><doi>10.1118/1.2757088</doi><tpages>8</tpages></addata></record> |
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| subjects | Acoustics Algorithms Animals biological tissues biomedical imaging brain Brain - pathology Brain Injuries - diagnostic imaging Brain Injuries - pathology brain vascular Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Cerebrovascular Circulation drug stimulation drugs Functional monitoring and imaging Haemodynamics Image Processing, Computer-Assisted image reconstruction Ischemia - pathology Medical image reconstruction Medical imaging Mice Models, Statistical Non‐ionizing radiation equipment and techniques Optical absorption optical tomography Phantoms, Imaging photoacoustic effect photoacoustic imaging photoacoustic signal Spatial resolution Spectroscopic and microscopic techniques in biophysics and medical physics Tissues Tomography - instrumentation Tomography - methods Tomography, X-Ray Computed - methods traumatic lesion |
| title | Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography |
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