Prevalence and risk factors for atrial fibrillation in dogs with myxomatous mitral valve disease
Background Atrial fibrillation (AF) is a common supraventricular arrhythmia more frequently observed in large breed dogs. Objectives Estimate the prevalence of AF in dogs with myxomatous mitral valve disease (MMVD) and identify risk factors for developing AF. Animals A total of 2194 client‐owned dog...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2020-11, Vol.34 (6), p.2223-2231 |
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| creator | Guglielmini, Carlo Goncalves Sousa, Marlos Baron Toaldo, Marco Valente, Carlotta Bentivoglio, Vinicius Mazzoldi, Chiara Bergamin, Ilaria Drigo, Michele Poser, Helen |
| description | Background
Atrial fibrillation (AF) is a common supraventricular arrhythmia more frequently observed in large breed dogs.
Objectives
Estimate the prevalence of AF in dogs with myxomatous mitral valve disease (MMVD) and identify risk factors for developing AF.
Animals
A total of 2194 client‐owned dogs with MMVD, including 1280, 588, 290, and 36 dogs in ACVIM stages B1, B2, C, and D, respectively.
Methods
Retrospective, cross‐sectional study. The medical databases of 3 veterinary teaching hospitals were reviewed. Inclusion criteria were a diagnosis of MMVD after complete cardiovascular evaluation and cardiac rhythm assessment using routine 2‐minute ECG or good quality ECG tracing during echocardiographic examination.
Results
Atrial fibrillation was diagnosed in 59 dogs with a prevalence of 2.7%. Univariate analysis showed that mixed breed, male sex, advanced ACVIM stage, left atrial and ventricular enlargement, fractional shortening (FS), and presence of pulmonary hypertension were significantly associated with development of AF. According to 2 multivariable models, the left atrium (LA)‐to‐aorta ratio (odds ratio [OR] = 14.011, 7.463‐26.304), early trans‐mitral velocity (OR = 2.204, 1.192‐4.076), body weight (OR = 1.094, 1.058‐1.130), and FS (OR = 0.899, 0.865‐0.934) and LA (OR = 5.28, 3.377‐8.092), advanced ACVIM stage (OR = 4.922, 1.481‐16.353), and FS (OR = 0.919, 0.881‐0.959) were significant predictors of AF for models 1 and 2, respectively.
Conclusions and Clinical Importance
Atrial fibrillation is an uncommon complication of MMVD and is significantly associated with the more advanced stage of the disease, increased LA dimension and body weight, and decreased FS. |
| doi_str_mv | 10.1111/jvim.15927 |
| format | Article |
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Atrial fibrillation (AF) is a common supraventricular arrhythmia more frequently observed in large breed dogs.
Objectives
Estimate the prevalence of AF in dogs with myxomatous mitral valve disease (MMVD) and identify risk factors for developing AF.
Animals
A total of 2194 client‐owned dogs with MMVD, including 1280, 588, 290, and 36 dogs in ACVIM stages B1, B2, C, and D, respectively.
Methods
Retrospective, cross‐sectional study. The medical databases of 3 veterinary teaching hospitals were reviewed. Inclusion criteria were a diagnosis of MMVD after complete cardiovascular evaluation and cardiac rhythm assessment using routine 2‐minute ECG or good quality ECG tracing during echocardiographic examination.
Results
Atrial fibrillation was diagnosed in 59 dogs with a prevalence of 2.7%. Univariate analysis showed that mixed breed, male sex, advanced ACVIM stage, left atrial and ventricular enlargement, fractional shortening (FS), and presence of pulmonary hypertension were significantly associated with development of AF. According to 2 multivariable models, the left atrium (LA)‐to‐aorta ratio (odds ratio [OR] = 14.011, 7.463‐26.304), early trans‐mitral velocity (OR = 2.204, 1.192‐4.076), body weight (OR = 1.094, 1.058‐1.130), and FS (OR = 0.899, 0.865‐0.934) and LA (OR = 5.28, 3.377‐8.092), advanced ACVIM stage (OR = 4.922, 1.481‐16.353), and FS (OR = 0.919, 0.881‐0.959) were significant predictors of AF for models 1 and 2, respectively.
Conclusions and Clinical Importance
Atrial fibrillation is an uncommon complication of MMVD and is significantly associated with the more advanced stage of the disease, increased LA dimension and body weight, and decreased FS.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/jvim.15927</identifier><identifier>PMID: 33031593</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>canine ; Cardiac arrhythmia ; Confidence intervals ; Congenital diseases ; Disease ; echocardiography ; electrocardiography ; epidemiology ; Heart failure ; Internal medicine ; Life Sciences & Biomedicine ; Pulmonary hypertension ; Questioning ; Risk factors ; Science & Technology ; SMALL ANIMAL ; Software ; Variables ; Velocity ; Veterinary Sciences</subject><ispartof>Journal of veterinary internal medicine, 2020-11, Vol.34 (6), p.2223-2231</ispartof><rights>2020 The Authors. published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>13</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000576038800001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4257-1d8ed653897808c65f4293d11c1b475254e94499c2e5e27922c096af3bb4ded73</citedby><cites>FETCH-LOGICAL-c4257-1d8ed653897808c65f4293d11c1b475254e94499c2e5e27922c096af3bb4ded73</cites><orcidid>0000-0001-7575-3646 ; 0000-0001-9609-1856</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694843/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694843/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,1419,2116,11569,27931,27932,28255,45581,45582,46059,46483,53798,53800</link.rule.ids></links><search><creatorcontrib>Guglielmini, Carlo</creatorcontrib><creatorcontrib>Goncalves Sousa, Marlos</creatorcontrib><creatorcontrib>Baron Toaldo, Marco</creatorcontrib><creatorcontrib>Valente, Carlotta</creatorcontrib><creatorcontrib>Bentivoglio, Vinicius</creatorcontrib><creatorcontrib>Mazzoldi, Chiara</creatorcontrib><creatorcontrib>Bergamin, Ilaria</creatorcontrib><creatorcontrib>Drigo, Michele</creatorcontrib><creatorcontrib>Poser, Helen</creatorcontrib><title>Prevalence and risk factors for atrial fibrillation in dogs with myxomatous mitral valve disease</title><title>Journal of veterinary internal medicine</title><addtitle>J VET INTERN MED</addtitle><description>Background
Atrial fibrillation (AF) is a common supraventricular arrhythmia more frequently observed in large breed dogs.
Objectives
Estimate the prevalence of AF in dogs with myxomatous mitral valve disease (MMVD) and identify risk factors for developing AF.
Animals
A total of 2194 client‐owned dogs with MMVD, including 1280, 588, 290, and 36 dogs in ACVIM stages B1, B2, C, and D, respectively.
Methods
Retrospective, cross‐sectional study. The medical databases of 3 veterinary teaching hospitals were reviewed. Inclusion criteria were a diagnosis of MMVD after complete cardiovascular evaluation and cardiac rhythm assessment using routine 2‐minute ECG or good quality ECG tracing during echocardiographic examination.
Results
Atrial fibrillation was diagnosed in 59 dogs with a prevalence of 2.7%. Univariate analysis showed that mixed breed, male sex, advanced ACVIM stage, left atrial and ventricular enlargement, fractional shortening (FS), and presence of pulmonary hypertension were significantly associated with development of AF. According to 2 multivariable models, the left atrium (LA)‐to‐aorta ratio (odds ratio [OR] = 14.011, 7.463‐26.304), early trans‐mitral velocity (OR = 2.204, 1.192‐4.076), body weight (OR = 1.094, 1.058‐1.130), and FS (OR = 0.899, 0.865‐0.934) and LA (OR = 5.28, 3.377‐8.092), advanced ACVIM stage (OR = 4.922, 1.481‐16.353), and FS (OR = 0.919, 0.881‐0.959) were significant predictors of AF for models 1 and 2, respectively.
Conclusions and Clinical Importance
Atrial fibrillation is an uncommon complication of MMVD and is significantly associated with the more advanced stage of the disease, increased LA dimension and body weight, and decreased FS.</description><subject>canine</subject><subject>Cardiac arrhythmia</subject><subject>Confidence intervals</subject><subject>Congenital diseases</subject><subject>Disease</subject><subject>echocardiography</subject><subject>electrocardiography</subject><subject>epidemiology</subject><subject>Heart failure</subject><subject>Internal medicine</subject><subject>Life Sciences & Biomedicine</subject><subject>Pulmonary hypertension</subject><subject>Questioning</subject><subject>Risk factors</subject><subject>Science & Technology</subject><subject>SMALL ANIMAL</subject><subject>Software</subject><subject>Variables</subject><subject>Velocity</subject><subject>Veterinary Sciences</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkUtv1DAUhS0EotPChl9giQ2iSvHb8QYJjXgUFcEC2BrHuWk9JHFrJ1Pm3-N0RpVggfDGlvydc8_VQegZJWe0nFebbRjOqDRMP0AraripqNLqIVqR2tBKKUGO0HHOG0KYlFI_RkecE14EfIV-fEmwdT2MHrAbW5xC_ok756eYMu5iwm5KwfW4C00Kfe-mEEccRtzGy4xvw3SFh92vOLgpzhkPYUqFLX5bwG3I4DI8QY8612d4erhP0Ld3b7-uP1QXn9-fr99cVF4wqSva1tAqyWuja1J7JTvBDG8p9bQRWjIpwAhhjGcggWnDmCdGuY43jWih1fwEvd77Xs_NAK2Hcclir1MYXNrZ6IL982cMV_Yybq1WRtSCF4MXB4MUb2bIkx1C9lB2HqEsZ9kyXjEqREGf_4Vu4pzGsl6hlFCEcbEkermnfIo5J-juw1Bil-LsUpy9K67A9R6-hSZ22YelkXsBIURqRXhdlxeh6zDdFbGO8zgV6en_SwtND3ToYfePSPbj9_NP-3C_AR1yu3U</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Guglielmini, Carlo</creator><creator>Goncalves Sousa, Marlos</creator><creator>Baron Toaldo, Marco</creator><creator>Valente, Carlotta</creator><creator>Bentivoglio, Vinicius</creator><creator>Mazzoldi, Chiara</creator><creator>Bergamin, Ilaria</creator><creator>Drigo, Michele</creator><creator>Poser, Helen</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7575-3646</orcidid><orcidid>https://orcid.org/0000-0001-9609-1856</orcidid></search><sort><creationdate>202011</creationdate><title>Prevalence and risk factors for atrial fibrillation in dogs with myxomatous mitral valve disease</title><author>Guglielmini, Carlo ; Goncalves Sousa, Marlos ; Baron Toaldo, Marco ; Valente, Carlotta ; Bentivoglio, Vinicius ; Mazzoldi, Chiara ; Bergamin, Ilaria ; Drigo, Michele ; Poser, Helen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4257-1d8ed653897808c65f4293d11c1b475254e94499c2e5e27922c096af3bb4ded73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>canine</topic><topic>Cardiac arrhythmia</topic><topic>Confidence intervals</topic><topic>Congenital diseases</topic><topic>Disease</topic><topic>echocardiography</topic><topic>electrocardiography</topic><topic>epidemiology</topic><topic>Heart failure</topic><topic>Internal medicine</topic><topic>Life Sciences & Biomedicine</topic><topic>Pulmonary hypertension</topic><topic>Questioning</topic><topic>Risk factors</topic><topic>Science & Technology</topic><topic>SMALL ANIMAL</topic><topic>Software</topic><topic>Variables</topic><topic>Velocity</topic><topic>Veterinary Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guglielmini, Carlo</creatorcontrib><creatorcontrib>Goncalves Sousa, Marlos</creatorcontrib><creatorcontrib>Baron Toaldo, Marco</creatorcontrib><creatorcontrib>Valente, Carlotta</creatorcontrib><creatorcontrib>Bentivoglio, Vinicius</creatorcontrib><creatorcontrib>Mazzoldi, Chiara</creatorcontrib><creatorcontrib>Bergamin, Ilaria</creatorcontrib><creatorcontrib>Drigo, Michele</creatorcontrib><creatorcontrib>Poser, Helen</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guglielmini, Carlo</au><au>Goncalves Sousa, Marlos</au><au>Baron Toaldo, Marco</au><au>Valente, Carlotta</au><au>Bentivoglio, Vinicius</au><au>Mazzoldi, Chiara</au><au>Bergamin, Ilaria</au><au>Drigo, Michele</au><au>Poser, Helen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and risk factors for atrial fibrillation in dogs with myxomatous mitral valve disease</atitle><jtitle>Journal of veterinary internal medicine</jtitle><stitle>J VET INTERN MED</stitle><date>2020-11</date><risdate>2020</risdate><volume>34</volume><issue>6</issue><spage>2223</spage><epage>2231</epage><pages>2223-2231</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
Atrial fibrillation (AF) is a common supraventricular arrhythmia more frequently observed in large breed dogs.
Objectives
Estimate the prevalence of AF in dogs with myxomatous mitral valve disease (MMVD) and identify risk factors for developing AF.
Animals
A total of 2194 client‐owned dogs with MMVD, including 1280, 588, 290, and 36 dogs in ACVIM stages B1, B2, C, and D, respectively.
Methods
Retrospective, cross‐sectional study. The medical databases of 3 veterinary teaching hospitals were reviewed. Inclusion criteria were a diagnosis of MMVD after complete cardiovascular evaluation and cardiac rhythm assessment using routine 2‐minute ECG or good quality ECG tracing during echocardiographic examination.
Results
Atrial fibrillation was diagnosed in 59 dogs with a prevalence of 2.7%. Univariate analysis showed that mixed breed, male sex, advanced ACVIM stage, left atrial and ventricular enlargement, fractional shortening (FS), and presence of pulmonary hypertension were significantly associated with development of AF. According to 2 multivariable models, the left atrium (LA)‐to‐aorta ratio (odds ratio [OR] = 14.011, 7.463‐26.304), early trans‐mitral velocity (OR = 2.204, 1.192‐4.076), body weight (OR = 1.094, 1.058‐1.130), and FS (OR = 0.899, 0.865‐0.934) and LA (OR = 5.28, 3.377‐8.092), advanced ACVIM stage (OR = 4.922, 1.481‐16.353), and FS (OR = 0.919, 0.881‐0.959) were significant predictors of AF for models 1 and 2, respectively.
Conclusions and Clinical Importance
Atrial fibrillation is an uncommon complication of MMVD and is significantly associated with the more advanced stage of the disease, increased LA dimension and body weight, and decreased FS.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33031593</pmid><doi>10.1111/jvim.15927</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7575-3646</orcidid><orcidid>https://orcid.org/0000-0001-9609-1856</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | canine Cardiac arrhythmia Confidence intervals Congenital diseases Disease echocardiography electrocardiography epidemiology Heart failure Internal medicine Life Sciences & Biomedicine Pulmonary hypertension Questioning Risk factors Science & Technology SMALL ANIMAL Software Variables Velocity Veterinary Sciences |
| title | Prevalence and risk factors for atrial fibrillation in dogs with myxomatous mitral valve disease |
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