Chalcone T4, a novel chalconic compound, inhibits inflammatory bone resorption in vivo and suppresses osteoclastogenesis in vitro
Objective This study aimed to assess the effect of a novel synthetic chalcone, Chalcone T4, on a murine model of periodontitis and on RANKL‐induced osteoclastogenesis in vitro. Background Chalcones are natural compounds with anti‐inflammatory properties, and its synthetic analogs with enhanced biolo...
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| Veröffentlicht in: | Journal of periodontal research 2021-06, Vol.56 (3), p.569-578 |
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| creator | Fernandes, Natalie Aparecida Rodrigues Camilli, Angelo Constantino Maldonado, Laura Andrea Gonzalez Pacheco, Cindy Grace Pérez Silva, Amanda Favoreto Molon, Rafael Scaf Spolidorio, Luiz Carlos Ribeiro de Assis, Letícia Regasini, Luis Octavio Rossa Junior, Carlos Guimarães‐Stabili, Morgana Rodrigues |
| description | Objective
This study aimed to assess the effect of a novel synthetic chalcone, Chalcone T4, on a murine model of periodontitis and on RANKL‐induced osteoclastogenesis in vitro.
Background
Chalcones are natural compounds with anti‐inflammatory properties, and its synthetic analogs with enhanced biological effects have potential as therapeutic agents. Periodontitis is characterized by chronic inflammation of the periodontium and alveolar bone resorption. Safe and effective anti‐inflammatory agents can have an important additive effect in the treatment in this disease.
Methods
Periodontitis was induced via the installation of a ligature around the first molar. Rats (n = 32) received Chalcone T4 (5 and 50 mg/kg) or distilled water by gavage daily for 15 days. Outcomes assessed were bone resorption (μCT), TNF‐α production (ELISA), cellular infiltrate, and collagen content (stereometric analysis, CD45+ cells by immunohistochemistry), and activation of NFATc1 and NF‐kB (immunohistochemistry). In vitro, RAW 264.7 were treated with Chalcone T4 and stimulated with RANKL for assessment of osteoclast differentiation (actin ring staining) and activity (pit assay).
Results
Chalcone T4 significantly reduced periodontitis‐associated bone resorption, as well as the cellular infiltrate, while increasing the collagen content. Production of TNF‐α, infiltration of CD45‐positive cells, and NF‐kB activation were markedly reduced. In vitro, chalcone T4 inhibited both osteoclast differentiation and activity.
Conclusion
Chalcone T4 significantly inhibited alveolar bone resorption and inflammation in vivo and RANKL‐induced osteoclastogenesis in vitro, suggesting a therapeutic role for this compound in the treatment of periodontitis. |
| doi_str_mv | 10.1111/jre.12857 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_wiley_primary_10_1111_jre_12857_JRE12857</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2494886842</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3537-d431560a7e9bfabd25711bda8c33f8c7187a6ead25e4713e37c2c594205e23753</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhS0EokNhwR9AltiAaFo_Y2eJovKoKiGhso4c54Z6lNjBTqaaJf-8HjJ0gYRUb3x973eujnwQek3JOc3nYhvhnDIt1RO0oSUhBVGlfIo2hDBWcKHFCXqR0pbkd6mq5-iE81LQTG7Q7_rWDDZ4wDfiDBvsww4GbNems9iGcQqL786w87eudXPKRT-YcTRziHvcHqQRUojT7ILPQ7xzu4CN73BapimPEiQc0gzBDibN4Sd4SC6t5BzDS_SsN0OCV8f7FP34dHlTfymuv33-Wn-8LiyXXBWd4FSWxCio2t60HZOK0rYz2nLea6uoVqYEk_sgFOXAlWVWVoIRCYwryU_Ru3XvFMOvBdLcjC5ZGAbjISypYaISWpdasIy-_QfdhiX67K5hkilJiKxUpt6vlI0hpQh9M0U3mrhvKGkOuTQ5l-ZPLpl9c9y4tCN0D-TfIDKgV-AO2tAn68BbeMByciVjmjCVK0JrN5vDb9c5mTlLPzxemumLI-0G2P_fcnP1_XL1fg_tSLjk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2527500597</pqid></control><display><type>article</type><title>Chalcone T4, a novel chalconic compound, inhibits inflammatory bone resorption in vivo and suppresses osteoclastogenesis in vitro</title><source>MEDLINE</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Wiley Online Library All Journals</source><creator>Fernandes, Natalie Aparecida Rodrigues ; Camilli, Angelo Constantino ; Maldonado, Laura Andrea Gonzalez ; Pacheco, Cindy Grace Pérez ; Silva, Amanda Favoreto ; Molon, Rafael Scaf ; Spolidorio, Luiz Carlos ; Ribeiro de Assis, Letícia ; Regasini, Luis Octavio ; Rossa Junior, Carlos ; Guimarães‐Stabili, Morgana Rodrigues</creator><creatorcontrib>Fernandes, Natalie Aparecida Rodrigues ; Camilli, Angelo Constantino ; Maldonado, Laura Andrea Gonzalez ; Pacheco, Cindy Grace Pérez ; Silva, Amanda Favoreto ; Molon, Rafael Scaf ; Spolidorio, Luiz Carlos ; Ribeiro de Assis, Letícia ; Regasini, Luis Octavio ; Rossa Junior, Carlos ; Guimarães‐Stabili, Morgana Rodrigues</creatorcontrib><description>Objective
This study aimed to assess the effect of a novel synthetic chalcone, Chalcone T4, on a murine model of periodontitis and on RANKL‐induced osteoclastogenesis in vitro.
Background
Chalcones are natural compounds with anti‐inflammatory properties, and its synthetic analogs with enhanced biological effects have potential as therapeutic agents. Periodontitis is characterized by chronic inflammation of the periodontium and alveolar bone resorption. Safe and effective anti‐inflammatory agents can have an important additive effect in the treatment in this disease.
Methods
Periodontitis was induced via the installation of a ligature around the first molar. Rats (n = 32) received Chalcone T4 (5 and 50 mg/kg) or distilled water by gavage daily for 15 days. Outcomes assessed were bone resorption (μCT), TNF‐α production (ELISA), cellular infiltrate, and collagen content (stereometric analysis, CD45+ cells by immunohistochemistry), and activation of NFATc1 and NF‐kB (immunohistochemistry). In vitro, RAW 264.7 were treated with Chalcone T4 and stimulated with RANKL for assessment of osteoclast differentiation (actin ring staining) and activity (pit assay).
Results
Chalcone T4 significantly reduced periodontitis‐associated bone resorption, as well as the cellular infiltrate, while increasing the collagen content. Production of TNF‐α, infiltration of CD45‐positive cells, and NF‐kB activation were markedly reduced. In vitro, chalcone T4 inhibited both osteoclast differentiation and activity.
Conclusion
Chalcone T4 significantly inhibited alveolar bone resorption and inflammation in vivo and RANKL‐induced osteoclastogenesis in vitro, suggesting a therapeutic role for this compound in the treatment of periodontitis.</description><identifier>ISSN: 0022-3484</identifier><identifier>EISSN: 1600-0765</identifier><identifier>DOI: 10.1111/jre.12857</identifier><identifier>PMID: 33641160</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>Actin ; Alveolar bone ; Alveolar Bone Loss - drug therapy ; Alveolar Bone Loss - prevention & control ; Animal models ; Animals ; Bone resorption ; Bone Resorption - drug therapy ; Bone Resorption - prevention & control ; CD45 antigen ; Cell activation ; Cell Differentiation ; chalcone ; Chalcone - pharmacology ; Chalcone - therapeutic use ; Chalcones - pharmacology ; Chalcones - therapeutic use ; Collagen ; Dentistry ; Dentistry, Oral Surgery & Medicine ; Enzyme-linked immunosorbent assay ; Gum disease ; Immunohistochemistry ; Inflammation ; Life Sciences & Biomedicine ; Mice ; Osteoclastogenesis ; Osteoclasts ; Osteogenesis ; Periodontitis ; Periodontium ; RANK Ligand ; Rats ; Science & Technology ; TRANCE protein ; Tumor necrosis factor</subject><ispartof>Journal of periodontal research, 2021-06, Vol.56 (3), p.569-578</ispartof><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2021 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>7</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000622802700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3537-d431560a7e9bfabd25711bda8c33f8c7187a6ead25e4713e37c2c594205e23753</citedby><cites>FETCH-LOGICAL-c3537-d431560a7e9bfabd25711bda8c33f8c7187a6ead25e4713e37c2c594205e23753</cites><orcidid>0000-0002-7157-527X ; 0000-0002-0592-542X ; 0000-0001-9869-8934 ; 0000-0003-4985-443X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjre.12857$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjre.12857$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,39265,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33641160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernandes, Natalie Aparecida Rodrigues</creatorcontrib><creatorcontrib>Camilli, Angelo Constantino</creatorcontrib><creatorcontrib>Maldonado, Laura Andrea Gonzalez</creatorcontrib><creatorcontrib>Pacheco, Cindy Grace Pérez</creatorcontrib><creatorcontrib>Silva, Amanda Favoreto</creatorcontrib><creatorcontrib>Molon, Rafael Scaf</creatorcontrib><creatorcontrib>Spolidorio, Luiz Carlos</creatorcontrib><creatorcontrib>Ribeiro de Assis, Letícia</creatorcontrib><creatorcontrib>Regasini, Luis Octavio</creatorcontrib><creatorcontrib>Rossa Junior, Carlos</creatorcontrib><creatorcontrib>Guimarães‐Stabili, Morgana Rodrigues</creatorcontrib><title>Chalcone T4, a novel chalconic compound, inhibits inflammatory bone resorption in vivo and suppresses osteoclastogenesis in vitro</title><title>Journal of periodontal research</title><addtitle>J PERIODONTAL RES</addtitle><addtitle>J Periodontal Res</addtitle><description>Objective
This study aimed to assess the effect of a novel synthetic chalcone, Chalcone T4, on a murine model of periodontitis and on RANKL‐induced osteoclastogenesis in vitro.
Background
Chalcones are natural compounds with anti‐inflammatory properties, and its synthetic analogs with enhanced biological effects have potential as therapeutic agents. Periodontitis is characterized by chronic inflammation of the periodontium and alveolar bone resorption. Safe and effective anti‐inflammatory agents can have an important additive effect in the treatment in this disease.
Methods
Periodontitis was induced via the installation of a ligature around the first molar. Rats (n = 32) received Chalcone T4 (5 and 50 mg/kg) or distilled water by gavage daily for 15 days. Outcomes assessed were bone resorption (μCT), TNF‐α production (ELISA), cellular infiltrate, and collagen content (stereometric analysis, CD45+ cells by immunohistochemistry), and activation of NFATc1 and NF‐kB (immunohistochemistry). In vitro, RAW 264.7 were treated with Chalcone T4 and stimulated with RANKL for assessment of osteoclast differentiation (actin ring staining) and activity (pit assay).
Results
Chalcone T4 significantly reduced periodontitis‐associated bone resorption, as well as the cellular infiltrate, while increasing the collagen content. Production of TNF‐α, infiltration of CD45‐positive cells, and NF‐kB activation were markedly reduced. In vitro, chalcone T4 inhibited both osteoclast differentiation and activity.
Conclusion
Chalcone T4 significantly inhibited alveolar bone resorption and inflammation in vivo and RANKL‐induced osteoclastogenesis in vitro, suggesting a therapeutic role for this compound in the treatment of periodontitis.</description><subject>Actin</subject><subject>Alveolar bone</subject><subject>Alveolar Bone Loss - drug therapy</subject><subject>Alveolar Bone Loss - prevention & control</subject><subject>Animal models</subject><subject>Animals</subject><subject>Bone resorption</subject><subject>Bone Resorption - drug therapy</subject><subject>Bone Resorption - prevention & control</subject><subject>CD45 antigen</subject><subject>Cell activation</subject><subject>Cell Differentiation</subject><subject>chalcone</subject><subject>Chalcone - pharmacology</subject><subject>Chalcone - therapeutic use</subject><subject>Chalcones - pharmacology</subject><subject>Chalcones - therapeutic use</subject><subject>Collagen</subject><subject>Dentistry</subject><subject>Dentistry, Oral Surgery & Medicine</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Gum disease</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Life Sciences & Biomedicine</subject><subject>Mice</subject><subject>Osteoclastogenesis</subject><subject>Osteoclasts</subject><subject>Osteogenesis</subject><subject>Periodontitis</subject><subject>Periodontium</subject><subject>RANK Ligand</subject><subject>Rats</subject><subject>Science & Technology</subject><subject>TRANCE protein</subject><subject>Tumor necrosis factor</subject><issn>0022-3484</issn><issn>1600-0765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EokNhwR9AltiAaFo_Y2eJovKoKiGhso4c54Z6lNjBTqaaJf-8HjJ0gYRUb3x973eujnwQek3JOc3nYhvhnDIt1RO0oSUhBVGlfIo2hDBWcKHFCXqR0pbkd6mq5-iE81LQTG7Q7_rWDDZ4wDfiDBvsww4GbNems9iGcQqL786w87eudXPKRT-YcTRziHvcHqQRUojT7ILPQ7xzu4CN73BapimPEiQc0gzBDibN4Sd4SC6t5BzDS_SsN0OCV8f7FP34dHlTfymuv33-Wn-8LiyXXBWd4FSWxCio2t60HZOK0rYz2nLea6uoVqYEk_sgFOXAlWVWVoIRCYwryU_Ru3XvFMOvBdLcjC5ZGAbjISypYaISWpdasIy-_QfdhiX67K5hkilJiKxUpt6vlI0hpQh9M0U3mrhvKGkOuTQ5l-ZPLpl9c9y4tCN0D-TfIDKgV-AO2tAn68BbeMByciVjmjCVK0JrN5vDb9c5mTlLPzxemumLI-0G2P_fcnP1_XL1fg_tSLjk</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Fernandes, Natalie Aparecida Rodrigues</creator><creator>Camilli, Angelo Constantino</creator><creator>Maldonado, Laura Andrea Gonzalez</creator><creator>Pacheco, Cindy Grace Pérez</creator><creator>Silva, Amanda Favoreto</creator><creator>Molon, Rafael Scaf</creator><creator>Spolidorio, Luiz Carlos</creator><creator>Ribeiro de Assis, Letícia</creator><creator>Regasini, Luis Octavio</creator><creator>Rossa Junior, Carlos</creator><creator>Guimarães‐Stabili, Morgana Rodrigues</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7157-527X</orcidid><orcidid>https://orcid.org/0000-0002-0592-542X</orcidid><orcidid>https://orcid.org/0000-0001-9869-8934</orcidid><orcidid>https://orcid.org/0000-0003-4985-443X</orcidid></search><sort><creationdate>202106</creationdate><title>Chalcone T4, a novel chalconic compound, inhibits inflammatory bone resorption in vivo and suppresses osteoclastogenesis in vitro</title><author>Fernandes, Natalie Aparecida Rodrigues ; Camilli, Angelo Constantino ; Maldonado, Laura Andrea Gonzalez ; Pacheco, Cindy Grace Pérez ; Silva, Amanda Favoreto ; Molon, Rafael Scaf ; Spolidorio, Luiz Carlos ; Ribeiro de Assis, Letícia ; Regasini, Luis Octavio ; Rossa Junior, Carlos ; Guimarães‐Stabili, Morgana Rodrigues</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-d431560a7e9bfabd25711bda8c33f8c7187a6ead25e4713e37c2c594205e23753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Actin</topic><topic>Alveolar bone</topic><topic>Alveolar Bone Loss - drug therapy</topic><topic>Alveolar Bone Loss - prevention & control</topic><topic>Animal models</topic><topic>Animals</topic><topic>Bone resorption</topic><topic>Bone Resorption - drug therapy</topic><topic>Bone Resorption - prevention & control</topic><topic>CD45 antigen</topic><topic>Cell activation</topic><topic>Cell Differentiation</topic><topic>chalcone</topic><topic>Chalcone - pharmacology</topic><topic>Chalcone - therapeutic use</topic><topic>Chalcones - pharmacology</topic><topic>Chalcones - therapeutic use</topic><topic>Collagen</topic><topic>Dentistry</topic><topic>Dentistry, Oral Surgery & Medicine</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Gum disease</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Life Sciences & Biomedicine</topic><topic>Mice</topic><topic>Osteoclastogenesis</topic><topic>Osteoclasts</topic><topic>Osteogenesis</topic><topic>Periodontitis</topic><topic>Periodontium</topic><topic>RANK Ligand</topic><topic>Rats</topic><topic>Science & Technology</topic><topic>TRANCE protein</topic><topic>Tumor necrosis factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernandes, Natalie Aparecida Rodrigues</creatorcontrib><creatorcontrib>Camilli, Angelo Constantino</creatorcontrib><creatorcontrib>Maldonado, Laura Andrea Gonzalez</creatorcontrib><creatorcontrib>Pacheco, Cindy Grace Pérez</creatorcontrib><creatorcontrib>Silva, Amanda Favoreto</creatorcontrib><creatorcontrib>Molon, Rafael Scaf</creatorcontrib><creatorcontrib>Spolidorio, Luiz Carlos</creatorcontrib><creatorcontrib>Ribeiro de Assis, Letícia</creatorcontrib><creatorcontrib>Regasini, Luis Octavio</creatorcontrib><creatorcontrib>Rossa Junior, Carlos</creatorcontrib><creatorcontrib>Guimarães‐Stabili, Morgana Rodrigues</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernandes, Natalie Aparecida Rodrigues</au><au>Camilli, Angelo Constantino</au><au>Maldonado, Laura Andrea Gonzalez</au><au>Pacheco, Cindy Grace Pérez</au><au>Silva, Amanda Favoreto</au><au>Molon, Rafael Scaf</au><au>Spolidorio, Luiz Carlos</au><au>Ribeiro de Assis, Letícia</au><au>Regasini, Luis Octavio</au><au>Rossa Junior, Carlos</au><au>Guimarães‐Stabili, Morgana Rodrigues</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chalcone T4, a novel chalconic compound, inhibits inflammatory bone resorption in vivo and suppresses osteoclastogenesis in vitro</atitle><jtitle>Journal of periodontal research</jtitle><stitle>J PERIODONTAL RES</stitle><addtitle>J Periodontal Res</addtitle><date>2021-06</date><risdate>2021</risdate><volume>56</volume><issue>3</issue><spage>569</spage><epage>578</epage><pages>569-578</pages><issn>0022-3484</issn><eissn>1600-0765</eissn><abstract>Objective
This study aimed to assess the effect of a novel synthetic chalcone, Chalcone T4, on a murine model of periodontitis and on RANKL‐induced osteoclastogenesis in vitro.
Background
Chalcones are natural compounds with anti‐inflammatory properties, and its synthetic analogs with enhanced biological effects have potential as therapeutic agents. Periodontitis is characterized by chronic inflammation of the periodontium and alveolar bone resorption. Safe and effective anti‐inflammatory agents can have an important additive effect in the treatment in this disease.
Methods
Periodontitis was induced via the installation of a ligature around the first molar. Rats (n = 32) received Chalcone T4 (5 and 50 mg/kg) or distilled water by gavage daily for 15 days. Outcomes assessed were bone resorption (μCT), TNF‐α production (ELISA), cellular infiltrate, and collagen content (stereometric analysis, CD45+ cells by immunohistochemistry), and activation of NFATc1 and NF‐kB (immunohistochemistry). In vitro, RAW 264.7 were treated with Chalcone T4 and stimulated with RANKL for assessment of osteoclast differentiation (actin ring staining) and activity (pit assay).
Results
Chalcone T4 significantly reduced periodontitis‐associated bone resorption, as well as the cellular infiltrate, while increasing the collagen content. Production of TNF‐α, infiltration of CD45‐positive cells, and NF‐kB activation were markedly reduced. In vitro, chalcone T4 inhibited both osteoclast differentiation and activity.
Conclusion
Chalcone T4 significantly inhibited alveolar bone resorption and inflammation in vivo and RANKL‐induced osteoclastogenesis in vitro, suggesting a therapeutic role for this compound in the treatment of periodontitis.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>33641160</pmid><doi>10.1111/jre.12857</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7157-527X</orcidid><orcidid>https://orcid.org/0000-0002-0592-542X</orcidid><orcidid>https://orcid.org/0000-0001-9869-8934</orcidid><orcidid>https://orcid.org/0000-0003-4985-443X</orcidid></addata></record> |
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| ispartof | Journal of periodontal research, 2021-06, Vol.56 (3), p.569-578 |
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| source | MEDLINE; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Wiley Online Library All Journals |
| subjects | Actin Alveolar bone Alveolar Bone Loss - drug therapy Alveolar Bone Loss - prevention & control Animal models Animals Bone resorption Bone Resorption - drug therapy Bone Resorption - prevention & control CD45 antigen Cell activation Cell Differentiation chalcone Chalcone - pharmacology Chalcone - therapeutic use Chalcones - pharmacology Chalcones - therapeutic use Collagen Dentistry Dentistry, Oral Surgery & Medicine Enzyme-linked immunosorbent assay Gum disease Immunohistochemistry Inflammation Life Sciences & Biomedicine Mice Osteoclastogenesis Osteoclasts Osteogenesis Periodontitis Periodontium RANK Ligand Rats Science & Technology TRANCE protein Tumor necrosis factor |
| title | Chalcone T4, a novel chalconic compound, inhibits inflammatory bone resorption in vivo and suppresses osteoclastogenesis in vitro |
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