Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury

Increased adenosine helps limit infarct size in ischaemia/reperfusion‐injured hearts. In cardiomyocytes, 90% of adenosine is catalysed by adenosine kinase (ADK) and ADK inhibition leads to higher concentrations of both intracellular adenosine and extracellular adenosine. However, the role of ADK inh...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2021-03, Vol.25 (6), p.2931-2943
Hauptverfasser:	Wang, Wenjun, Wang, Bailu, Sun, Shukun, Cao, Shengchuan, Zhai, Xiaoxuan, Zhang, Chuanxin, Zhang, Qun, Yuan, Qiuhuan, Sun, Yi, Xue, Mengyang, Ma, Jingjing, Xu, Feng, Wei, Shujian, Chen, Yuguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine kinase AKT protein Antibodies Apoptosis Ca2+/calmodulin-dependent protein kinase II Cardiac function Cardiomyocytes Caspase Hypoxia IAP protein Inflammation Ischemia Kinases Laboratory animals myocardial ischaemia/reperfusion injury Necroptosis Original Oxidative stress Phosphorylation Reperfusion Rodents Transmission electron microscopy XIAP protein X‐linked inhibitor of apoptosis protein
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