Local delivery of fingolimod through PLGA nanoparticles and PuraMatrix‐embedded neural precursor cells promote motor function recovery and tissue repair in spinal cord injury

Spinal cord injury (SCI) is a devastating clinical problem that can lead to permanent motor dysfunction. Fingolimod (FTY720) is a sphingosine structural analogue, and recently, its therapeutic benefits in SCI have been reported. The present study aimed to evaluate the therapeutic efficacy of fingoli...

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Veröffentlicht in:	The European journal of neuroscience 2021-08, Vol.54 (4), p.5620-5637
Hauptverfasser:	Zeraatpisheh, Zahra, Mirzaei, Esmaeil, Nami, Mohammad, Alipour, Hamed, Mahdavipour, Marzieh, Sarkoohi, Parisa, Torabi, Somayyeh, Azari, Hassan, Aligholi, Hadi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytology Embryos Evaporation fingolimod FTY720 Glycolic acid mouse nano scaffold Nanoparticles Neural stem cells neural tissue engineering Phenotypes Polylactide-co-glycolide Progenitor cells Recovery of function Spectroscopy Spinal cord injuries spinal cord injury Tissue engineering Transplantation
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