Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4‐ATF3‐CHOP axis

Objective Withaferin A (WA) is a bioactive compound with a remarkable anti‐cancer effect derived from Withania somnifera, commonly known as ashwagandha. However, the anti‐cancer mechanisms of WA in glioblastoma multiforme (GBM) are still unclear. Materials and Methods Cell viability assays and xenog...

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Veröffentlicht in:	Cell proliferation 2020-01, Vol.53 (1), p.e12706-n/a, Article 12706
Hauptverfasser:	Tang, Qin, Ren, Liwen, Liu, Jinyi, Li, Wan, Zheng, Xiangjin, Wang, Jinhua, Du, Guanhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 3 Activating Transcription Factor 3 - metabolism Activating Transcription Factor 4 - metabolism Animals Antibodies Apoptosis BIM protein Bioactive compounds Cancer Cancer therapies Cell Biology Cell cycle Cell Line, Tumor Cell viability Cyclin-dependent kinase inhibitor p21 Endoplasmic reticulum Flow cytometry G2 Phase Cell Cycle Checkpoints - drug effects Gene silencing Genes Glioblastoma Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma cells Homeostasis Humans Immunofluorescence Life Sciences & Biomedicine M Phase Cell Cycle Checkpoints - drug effects Mice Mice, Nude Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Optimization Original p53 Protein Penicillin Proteins Science & Technology Signal transduction Signal Transduction - drug effects siRNA Software Transcription Factor CHOP - metabolism unfolded protein response Western blotting Withanolides - pharmacology Xenograft Model Antitumor Assays Xenografts
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