Duration of mechanical ventilation and prediction of bronchopulmonary dysplasia and home oxygen in extremely preterm infants
Aim To determine whether the duration of invasive ventilation predicted the development of bronchopulmonary dysplasia (BPD) and need for discharge home on supplementary oxygen in extremely preterm infants. Methods Retrospective whole‐population study of all infants 8 days predicted BPD development w...
Gespeichert in:
| Veröffentlicht in: | Acta Paediatrica 2021-07, Vol.110 (7), p.2052-2058 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2058 |
|---|---|
| container_issue | 7 |
| container_start_page | 2052 |
| container_title | Acta Paediatrica |
| container_volume | 110 |
| creator | Dassios, Theodore Williams, Emma E. Hickey, Ann Greenough, Anne |
| description | Aim
To determine whether the duration of invasive ventilation predicted the development of bronchopulmonary dysplasia (BPD) and need for discharge home on supplementary oxygen in extremely preterm infants.
Methods
Retrospective whole‐population study of all infants 8 days predicted BPD development with 71% sensitivity and 71% specificity and mechanical ventilation for >10 days predicted discharge on home oxygen with 66% sensitivity and 65% specificity.
Conclusion
In extremely preterm infants, the duration of invasive support predicted BPD and need for home oxygen with moderate sensitivity and specificity. |
| doi_str_mv | 10.1111/apa.15801 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_wiley_primary_10_1111_apa_15801_APA15801</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2487430765</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3531-c4d38373c3c14d963b81c89a9055975dc8bc9e7318bffc1ec4f54d2e98da7043</originalsourceid><addsrcrecordid>eNp10T1r3TAUBmBRGprbpEP_QDF0aQcn-rTl8ZJ-QiAZsgtZOu5VkCVXstMY-uOrxEmHQrUIpIeXw3kRekvwGSnnXE_6jAiJyQu0I40gNaW0fYl2WGJWCyrYMXqd8y3GlHW8eYWOGRNC4Kbbod-flqRnF0MVh2oEc9DBGe2rOwiz89uPDraaElhnnmGfYjCHOC1-jEGntbJrnrzOTj_iQxyhivfrDwiVCxXczwlG8OtDygxpLI-DDnM-RUeD9hnePN0n6ObL55uLb_Xl1dfvF_vL2jDBSG24ZZK1zDBDuO0a1ktiZKc7LETXCmtkbzpoGZH9MBgChg-CWwqdtLrFnJ2gD1vslOLPBfKsRpcNeK8DxCUrymXLGW4bUej7f-htXFIowykqOJMdZ5QW9XFTJsWcEwxqSm4se1AEq4dGVGlEPTZS7LunxKUfwf6VzxUUcL6BX87D-v8ktb_eb5F_AKRilwI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2543894322</pqid></control><display><type>article</type><title>Duration of mechanical ventilation and prediction of bronchopulmonary dysplasia and home oxygen in extremely preterm infants</title><source>Wiley Journals</source><source>Alma/SFX Local Collection</source><creator>Dassios, Theodore ; Williams, Emma E. ; Hickey, Ann ; Greenough, Anne</creator><creatorcontrib>Dassios, Theodore ; Williams, Emma E. ; Hickey, Ann ; Greenough, Anne</creatorcontrib><description>Aim
To determine whether the duration of invasive ventilation predicted the development of bronchopulmonary dysplasia (BPD) and need for discharge home on supplementary oxygen in extremely preterm infants.
Methods
Retrospective whole‐population study of all infants <28 weeks of gestation admitted to a neonatal unit in England between 2014 and 2018. BPD development was defined as any respiratory support at 36 weeks postmenstrual age. The performance of the duration of mechanical ventilation to predict BPD or discharge home on oxygen was assessed by receiver operator characteristic curve analysis.
Results
The 11,806 infants had a median (IQR) gestational age of 26.0(24.9–27.1) weeks and birthweight of 0.81(0.67–0.96) kg. At discharge from neonatal care, 9,415 infants (79.7%) were alive. The incidence of BPD was 57.5% and of home oxygen 29.4%. Mechanical ventilation duration had areas under the curve of 0.793 and 0.703 in predicting BPD and home oxygen, respectively. Mechanical ventilation for >8 days predicted BPD development with 71% sensitivity and 71% specificity and mechanical ventilation for >10 days predicted discharge on home oxygen with 66% sensitivity and 65% specificity.
Conclusion
In extremely preterm infants, the duration of invasive support predicted BPD and need for home oxygen with moderate sensitivity and specificity.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/apa.15801</identifier><identifier>PMID: 33555069</identifier><language>eng</language><publisher>Norway: Wiley Subscription Services, Inc</publisher><subject>Birth weight ; bronchopulmonary dysplasia ; Dysplasia ; England ; extremely preterm infants ; Gestational age ; home oxygen ; Infants ; Lung diseases ; Mechanical ventilation ; neonatal outcomes ; Neonates ; Newborn babies ; Oxygen ; Population studies ; Premature babies ; Ventilators</subject><ispartof>Acta Paediatrica, 2021-07, Vol.110 (7), p.2052-2058</ispartof><rights>2021 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd</rights><rights>2021 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-c4d38373c3c14d963b81c89a9055975dc8bc9e7318bffc1ec4f54d2e98da7043</citedby><cites>FETCH-LOGICAL-c3531-c4d38373c3c14d963b81c89a9055975dc8bc9e7318bffc1ec4f54d2e98da7043</cites><orcidid>0000-0002-8672-5349 ; 0000-0001-5258-5301</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapa.15801$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapa.15801$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33555069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dassios, Theodore</creatorcontrib><creatorcontrib>Williams, Emma E.</creatorcontrib><creatorcontrib>Hickey, Ann</creatorcontrib><creatorcontrib>Greenough, Anne</creatorcontrib><title>Duration of mechanical ventilation and prediction of bronchopulmonary dysplasia and home oxygen in extremely preterm infants</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim
To determine whether the duration of invasive ventilation predicted the development of bronchopulmonary dysplasia (BPD) and need for discharge home on supplementary oxygen in extremely preterm infants.
Methods
Retrospective whole‐population study of all infants <28 weeks of gestation admitted to a neonatal unit in England between 2014 and 2018. BPD development was defined as any respiratory support at 36 weeks postmenstrual age. The performance of the duration of mechanical ventilation to predict BPD or discharge home on oxygen was assessed by receiver operator characteristic curve analysis.
Results
The 11,806 infants had a median (IQR) gestational age of 26.0(24.9–27.1) weeks and birthweight of 0.81(0.67–0.96) kg. At discharge from neonatal care, 9,415 infants (79.7%) were alive. The incidence of BPD was 57.5% and of home oxygen 29.4%. Mechanical ventilation duration had areas under the curve of 0.793 and 0.703 in predicting BPD and home oxygen, respectively. Mechanical ventilation for >8 days predicted BPD development with 71% sensitivity and 71% specificity and mechanical ventilation for >10 days predicted discharge on home oxygen with 66% sensitivity and 65% specificity.
Conclusion
In extremely preterm infants, the duration of invasive support predicted BPD and need for home oxygen with moderate sensitivity and specificity.</description><subject>Birth weight</subject><subject>bronchopulmonary dysplasia</subject><subject>Dysplasia</subject><subject>England</subject><subject>extremely preterm infants</subject><subject>Gestational age</subject><subject>home oxygen</subject><subject>Infants</subject><subject>Lung diseases</subject><subject>Mechanical ventilation</subject><subject>neonatal outcomes</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Oxygen</subject><subject>Population studies</subject><subject>Premature babies</subject><subject>Ventilators</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10T1r3TAUBmBRGprbpEP_QDF0aQcn-rTl8ZJ-QiAZsgtZOu5VkCVXstMY-uOrxEmHQrUIpIeXw3kRekvwGSnnXE_6jAiJyQu0I40gNaW0fYl2WGJWCyrYMXqd8y3GlHW8eYWOGRNC4Kbbod-flqRnF0MVh2oEc9DBGe2rOwiz89uPDraaElhnnmGfYjCHOC1-jEGntbJrnrzOTj_iQxyhivfrDwiVCxXczwlG8OtDygxpLI-DDnM-RUeD9hnePN0n6ObL55uLb_Xl1dfvF_vL2jDBSG24ZZK1zDBDuO0a1ktiZKc7LETXCmtkbzpoGZH9MBgChg-CWwqdtLrFnJ2gD1vslOLPBfKsRpcNeK8DxCUrymXLGW4bUej7f-htXFIowykqOJMdZ5QW9XFTJsWcEwxqSm4se1AEq4dGVGlEPTZS7LunxKUfwf6VzxUUcL6BX87D-v8ktb_eb5F_AKRilwI</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Dassios, Theodore</creator><creator>Williams, Emma E.</creator><creator>Hickey, Ann</creator><creator>Greenough, Anne</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8672-5349</orcidid><orcidid>https://orcid.org/0000-0001-5258-5301</orcidid></search><sort><creationdate>202107</creationdate><title>Duration of mechanical ventilation and prediction of bronchopulmonary dysplasia and home oxygen in extremely preterm infants</title><author>Dassios, Theodore ; Williams, Emma E. ; Hickey, Ann ; Greenough, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-c4d38373c3c14d963b81c89a9055975dc8bc9e7318bffc1ec4f54d2e98da7043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Birth weight</topic><topic>bronchopulmonary dysplasia</topic><topic>Dysplasia</topic><topic>England</topic><topic>extremely preterm infants</topic><topic>Gestational age</topic><topic>home oxygen</topic><topic>Infants</topic><topic>Lung diseases</topic><topic>Mechanical ventilation</topic><topic>neonatal outcomes</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Oxygen</topic><topic>Population studies</topic><topic>Premature babies</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dassios, Theodore</creatorcontrib><creatorcontrib>Williams, Emma E.</creatorcontrib><creatorcontrib>Hickey, Ann</creatorcontrib><creatorcontrib>Greenough, Anne</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dassios, Theodore</au><au>Williams, Emma E.</au><au>Hickey, Ann</au><au>Greenough, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duration of mechanical ventilation and prediction of bronchopulmonary dysplasia and home oxygen in extremely preterm infants</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2021-07</date><risdate>2021</risdate><volume>110</volume><issue>7</issue><spage>2052</spage><epage>2058</epage><pages>2052-2058</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim
To determine whether the duration of invasive ventilation predicted the development of bronchopulmonary dysplasia (BPD) and need for discharge home on supplementary oxygen in extremely preterm infants.
Methods
Retrospective whole‐population study of all infants <28 weeks of gestation admitted to a neonatal unit in England between 2014 and 2018. BPD development was defined as any respiratory support at 36 weeks postmenstrual age. The performance of the duration of mechanical ventilation to predict BPD or discharge home on oxygen was assessed by receiver operator characteristic curve analysis.
Results
The 11,806 infants had a median (IQR) gestational age of 26.0(24.9–27.1) weeks and birthweight of 0.81(0.67–0.96) kg. At discharge from neonatal care, 9,415 infants (79.7%) were alive. The incidence of BPD was 57.5% and of home oxygen 29.4%. Mechanical ventilation duration had areas under the curve of 0.793 and 0.703 in predicting BPD and home oxygen, respectively. Mechanical ventilation for >8 days predicted BPD development with 71% sensitivity and 71% specificity and mechanical ventilation for >10 days predicted discharge on home oxygen with 66% sensitivity and 65% specificity.
Conclusion
In extremely preterm infants, the duration of invasive support predicted BPD and need for home oxygen with moderate sensitivity and specificity.</abstract><cop>Norway</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33555069</pmid><doi>10.1111/apa.15801</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8672-5349</orcidid><orcidid>https://orcid.org/0000-0001-5258-5301</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0803-5253 |
| ispartof | Acta Paediatrica, 2021-07, Vol.110 (7), p.2052-2058 |
| issn | 0803-5253 1651-2227 |
| language | eng |
| recordid | cdi_wiley_primary_10_1111_apa_15801_APA15801 |
| source | Wiley Journals; Alma/SFX Local Collection |
| subjects | Birth weight bronchopulmonary dysplasia Dysplasia England extremely preterm infants Gestational age home oxygen Infants Lung diseases Mechanical ventilation neonatal outcomes Neonates Newborn babies Oxygen Population studies Premature babies Ventilators |
| title | Duration of mechanical ventilation and prediction of bronchopulmonary dysplasia and home oxygen in extremely preterm infants |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T17%3A48%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Duration%20of%20mechanical%20ventilation%20and%20prediction%20of%20bronchopulmonary%20dysplasia%20and%20home%20oxygen%20in%20extremely%20preterm%20infants&rft.jtitle=Acta%20Paediatrica&rft.au=Dassios,%20Theodore&rft.date=2021-07&rft.volume=110&rft.issue=7&rft.spage=2052&rft.epage=2058&rft.pages=2052-2058&rft.issn=0803-5253&rft.eissn=1651-2227&rft_id=info:doi/10.1111/apa.15801&rft_dat=%3Cproquest_cross%3E2487430765%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2543894322&rft_id=info:pmid/33555069&rfr_iscdi=true |