Radiosynthesis of a Novel 11C‐Labeled Derivative of 4’‐O‐Methylhonokiol and Its Preliminary Evaluation in an LPS Rat Model of Neuroinflammation

Cyclooxygenase type 2 (COX‐2) is an attractive biomarker for the visualization of neuroinflammation processes by positron emission tomography (PET). Neolignan 4’‐O‐methylhonokiol (MH) is known to have high anti‐inflammatory activity and inhibits the expression of COX‐2. We synthesized 4′‐[11C]methox...

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Veröffentlicht in:	ChemistrySelect (Weinheim) 2020-03, Vol.5 (9), p.2685-2689
Hauptverfasser:	Kiseleva, Mariia M, Vaulina, Daria D, Sivak, Konstantin V, Alexandrov, Andrey G, Kuzmich, Nikolay N, Viktorov, Nikolai B, Kuznetsova, Olga F, Gomzina, Natalia A
Format:	Artikel
Sprache:	eng
Schlagworte:	biodistribution carbon-11 cyclooxygenase 2 (COX-2) inflammation radiopharmaceuticals
Online-Zugang:	Volltext
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