Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy
Background This two‐part study explored the safety, feasibility, and efficacy of a mild–moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD). Methods First, we used a dose escalation paradigm with varying intensity and frequency of leg isometri...
Gespeichert in:
| Veröffentlicht in: | Muscle & nerve 2021-03, Vol.63 (3), p.320-326 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 326 |
|---|---|
| container_issue | 3 |
| container_start_page | 320 |
| container_title | Muscle & nerve |
| container_volume | 63 |
| creator | Lott, Donovan J. Taivassalo, Tanja Cooke, Korey D. Park, Hyunjun Moslemi, Zahra Batra, Abhinandan Forbes, Sean C. Byrne, Barry J. Walter, Glenn A. Vandenborne, Krista |
| description | Background
This two‐part study explored the safety, feasibility, and efficacy of a mild–moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD).
Methods
First, we used a dose escalation paradigm with varying intensity and frequency of leg isometric exercise to determine the dose response and safety in 10 boys. Second, we examined safety and feasibility of a 12‐wk in‐home, remotely supervised, mild–moderate intensity strengthening program in eight boys. Safety measures included T2 MRI, creatine kinase levels, and pain. Peak strength and function (time to ascend/descend four stairs) were also measured.
Results
Dose‐escalation revealed no signs of muscle damage. Seven of the eight boys completed the 12‐wk in‐home program with a compliance of 84.9%, no signs of muscle damage, and improvements in strength (knee extensors P |
| doi_str_mv | 10.1002/mus.27137 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_wiley_primary_10_1002_mus_27137_MUS27137</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2468666389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4437-84f394e679d6a6e6a70d754c56ff7e62194914fdb6dce9fe132feb611370d6bf3</originalsourceid><addsrcrecordid>eNqNkV-L1DAUxYMo7uzqg19ACr4o2t2kSZPmRZDxL6z4sC6ILyFNb2aytMmYtK799qbMOKgg-HIvN_ndw7kchB4RfE4wri6GKZ1XglBxB60IlqJktWzuohUmrCk5lV9O0GlKNxhj0nBxH51QWsk6Dyv09UpbGOcXhQWdXOt6twzadwVY64w2cxFskcYIfjNuwTu_KeAHROMSFM4XryeTXz0U2YOZeh2Lbs502G3nB-ie1X2Ch4d-hq7fvvm8fl9efnr3Yf3qsjSMUVE2zFLJgAvZcc2Ba4E7UTNTc2sF8IpIJgmzXcs7A9ICoZWFlpN8Lu54a-kZernX3U3tABnyY9S92kU36DiroJ3688e7rdqE70pWNZOYZYGnB4EYvk2QRjW4ZKDvtYcwJVUx3nDOaSMz-uQv9CZM0efzMiUxlaKucKae7SkTQ0oR7NEMwWpJTA2L7JJYZh__7v5I_oooA80euIU22GQceANHLGfKMW7qXJZ4127Uowt-HSY_5tXn_7-a6YsD7XqY_21Zfby-2nv_CYzqwnc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2490397520</pqid></control><display><type>article</type><title>Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Lott, Donovan J. ; Taivassalo, Tanja ; Cooke, Korey D. ; Park, Hyunjun ; Moslemi, Zahra ; Batra, Abhinandan ; Forbes, Sean C. ; Byrne, Barry J. ; Walter, Glenn A. ; Vandenborne, Krista</creator><creatorcontrib>Lott, Donovan J. ; Taivassalo, Tanja ; Cooke, Korey D. ; Park, Hyunjun ; Moslemi, Zahra ; Batra, Abhinandan ; Forbes, Sean C. ; Byrne, Barry J. ; Walter, Glenn A. ; Vandenborne, Krista</creatorcontrib><description>Background
This two‐part study explored the safety, feasibility, and efficacy of a mild–moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD).
Methods
First, we used a dose escalation paradigm with varying intensity and frequency of leg isometric exercise to determine the dose response and safety in 10 boys. Second, we examined safety and feasibility of a 12‐wk in‐home, remotely supervised, mild–moderate intensity strengthening program in eight boys. Safety measures included T2 MRI, creatine kinase levels, and pain. Peak strength and function (time to ascend/descend four stairs) were also measured.
Results
Dose‐escalation revealed no signs of muscle damage. Seven of the eight boys completed the 12‐wk in‐home program with a compliance of 84.9%, no signs of muscle damage, and improvements in strength (knee extensors P < .01; knee flexors P < .05) and function (descending steps P < .05).
Conclusions
An in‐home, mild–moderate intensity leg exercise program is safe with potential to positively impact both strength and function in ambulatory boys with DMD.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.27137</identifier><identifier>PMID: 33295018</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Child ; Clinical Neurology ; Creatine ; Creatine kinase ; Creatine Kinase - blood ; Damage ; Duchenne muscular dystrophy ; Duchenne's muscular dystrophy ; Dystrophy ; Exercise ; Exercise Therapy - methods ; Feasibility Studies ; Flexors ; functional ability ; Hamstring Muscles - diagnostic imaging ; Humans ; in‐home exercise program ; isometric exercise ; Kinases ; Knee ; Leg ; Life Sciences & Biomedicine ; Magnetic Resonance Imaging ; Male ; Muscle contraction ; Muscle Strength ; Muscle, Skeletal - diagnostic imaging ; Muscles ; Muscular dystrophy ; Muscular Dystrophy, Duchenne - blood ; Muscular Dystrophy, Duchenne - diagnostic imaging ; Muscular Dystrophy, Duchenne - rehabilitation ; Neurosciences ; Neurosciences & Neurology ; Pain ; Quadriceps Muscle - diagnostic imaging ; Safety ; Safety measures ; Science & Technology ; Stairways ; Strengthening ; T2 MRI ; Treatment Outcome</subject><ispartof>Muscle & nerve, 2021-03, Vol.63 (3), p.320-326</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><rights>2021 Wiley Periodicals, LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>30</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000600856000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4437-84f394e679d6a6e6a70d754c56ff7e62194914fdb6dce9fe132feb611370d6bf3</citedby><cites>FETCH-LOGICAL-c4437-84f394e679d6a6e6a70d754c56ff7e62194914fdb6dce9fe132feb611370d6bf3</cites><orcidid>0000-0002-7302-1756</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.27137$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.27137$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,782,786,887,1419,27933,27934,39267,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33295018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lott, Donovan J.</creatorcontrib><creatorcontrib>Taivassalo, Tanja</creatorcontrib><creatorcontrib>Cooke, Korey D.</creatorcontrib><creatorcontrib>Park, Hyunjun</creatorcontrib><creatorcontrib>Moslemi, Zahra</creatorcontrib><creatorcontrib>Batra, Abhinandan</creatorcontrib><creatorcontrib>Forbes, Sean C.</creatorcontrib><creatorcontrib>Byrne, Barry J.</creatorcontrib><creatorcontrib>Walter, Glenn A.</creatorcontrib><creatorcontrib>Vandenborne, Krista</creatorcontrib><title>Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy</title><title>Muscle & nerve</title><addtitle>MUSCLE NERVE</addtitle><addtitle>Muscle Nerve</addtitle><description>Background
This two‐part study explored the safety, feasibility, and efficacy of a mild–moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD).
Methods
First, we used a dose escalation paradigm with varying intensity and frequency of leg isometric exercise to determine the dose response and safety in 10 boys. Second, we examined safety and feasibility of a 12‐wk in‐home, remotely supervised, mild–moderate intensity strengthening program in eight boys. Safety measures included T2 MRI, creatine kinase levels, and pain. Peak strength and function (time to ascend/descend four stairs) were also measured.
Results
Dose‐escalation revealed no signs of muscle damage. Seven of the eight boys completed the 12‐wk in‐home program with a compliance of 84.9%, no signs of muscle damage, and improvements in strength (knee extensors P < .01; knee flexors P < .05) and function (descending steps P < .05).
Conclusions
An in‐home, mild–moderate intensity leg exercise program is safe with potential to positively impact both strength and function in ambulatory boys with DMD.</description><subject>Child</subject><subject>Clinical Neurology</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Creatine Kinase - blood</subject><subject>Damage</subject><subject>Duchenne muscular dystrophy</subject><subject>Duchenne's muscular dystrophy</subject><subject>Dystrophy</subject><subject>Exercise</subject><subject>Exercise Therapy - methods</subject><subject>Feasibility Studies</subject><subject>Flexors</subject><subject>functional ability</subject><subject>Hamstring Muscles - diagnostic imaging</subject><subject>Humans</subject><subject>in‐home exercise program</subject><subject>isometric exercise</subject><subject>Kinases</subject><subject>Knee</subject><subject>Leg</subject><subject>Life Sciences & Biomedicine</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Muscle contraction</subject><subject>Muscle Strength</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscles</subject><subject>Muscular dystrophy</subject><subject>Muscular Dystrophy, Duchenne - blood</subject><subject>Muscular Dystrophy, Duchenne - diagnostic imaging</subject><subject>Muscular Dystrophy, Duchenne - rehabilitation</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Pain</subject><subject>Quadriceps Muscle - diagnostic imaging</subject><subject>Safety</subject><subject>Safety measures</subject><subject>Science & Technology</subject><subject>Stairways</subject><subject>Strengthening</subject><subject>T2 MRI</subject><subject>Treatment Outcome</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkV-L1DAUxYMo7uzqg19ACr4o2t2kSZPmRZDxL6z4sC6ILyFNb2aytMmYtK799qbMOKgg-HIvN_ndw7kchB4RfE4wri6GKZ1XglBxB60IlqJktWzuohUmrCk5lV9O0GlKNxhj0nBxH51QWsk6Dyv09UpbGOcXhQWdXOt6twzadwVY64w2cxFskcYIfjNuwTu_KeAHROMSFM4XryeTXz0U2YOZeh2Lbs502G3nB-ie1X2Ch4d-hq7fvvm8fl9efnr3Yf3qsjSMUVE2zFLJgAvZcc2Ba4E7UTNTc2sF8IpIJgmzXcs7A9ICoZWFlpN8Lu54a-kZernX3U3tABnyY9S92kU36DiroJ3688e7rdqE70pWNZOYZYGnB4EYvk2QRjW4ZKDvtYcwJVUx3nDOaSMz-uQv9CZM0efzMiUxlaKucKae7SkTQ0oR7NEMwWpJTA2L7JJYZh__7v5I_oooA80euIU22GQceANHLGfKMW7qXJZ4127Uowt-HSY_5tXn_7-a6YsD7XqY_21Zfby-2nv_CYzqwnc</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Lott, Donovan J.</creator><creator>Taivassalo, Tanja</creator><creator>Cooke, Korey D.</creator><creator>Park, Hyunjun</creator><creator>Moslemi, Zahra</creator><creator>Batra, Abhinandan</creator><creator>Forbes, Sean C.</creator><creator>Byrne, Barry J.</creator><creator>Walter, Glenn A.</creator><creator>Vandenborne, Krista</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7302-1756</orcidid></search><sort><creationdate>202103</creationdate><title>Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy</title><author>Lott, Donovan J. ; Taivassalo, Tanja ; Cooke, Korey D. ; Park, Hyunjun ; Moslemi, Zahra ; Batra, Abhinandan ; Forbes, Sean C. ; Byrne, Barry J. ; Walter, Glenn A. ; Vandenborne, Krista</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4437-84f394e679d6a6e6a70d754c56ff7e62194914fdb6dce9fe132feb611370d6bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Child</topic><topic>Clinical Neurology</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Creatine Kinase - blood</topic><topic>Damage</topic><topic>Duchenne muscular dystrophy</topic><topic>Duchenne's muscular dystrophy</topic><topic>Dystrophy</topic><topic>Exercise</topic><topic>Exercise Therapy - methods</topic><topic>Feasibility Studies</topic><topic>Flexors</topic><topic>functional ability</topic><topic>Hamstring Muscles - diagnostic imaging</topic><topic>Humans</topic><topic>in‐home exercise program</topic><topic>isometric exercise</topic><topic>Kinases</topic><topic>Knee</topic><topic>Leg</topic><topic>Life Sciences & Biomedicine</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Muscle contraction</topic><topic>Muscle Strength</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscles</topic><topic>Muscular dystrophy</topic><topic>Muscular Dystrophy, Duchenne - blood</topic><topic>Muscular Dystrophy, Duchenne - diagnostic imaging</topic><topic>Muscular Dystrophy, Duchenne - rehabilitation</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Pain</topic><topic>Quadriceps Muscle - diagnostic imaging</topic><topic>Safety</topic><topic>Safety measures</topic><topic>Science & Technology</topic><topic>Stairways</topic><topic>Strengthening</topic><topic>T2 MRI</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lott, Donovan J.</creatorcontrib><creatorcontrib>Taivassalo, Tanja</creatorcontrib><creatorcontrib>Cooke, Korey D.</creatorcontrib><creatorcontrib>Park, Hyunjun</creatorcontrib><creatorcontrib>Moslemi, Zahra</creatorcontrib><creatorcontrib>Batra, Abhinandan</creatorcontrib><creatorcontrib>Forbes, Sean C.</creatorcontrib><creatorcontrib>Byrne, Barry J.</creatorcontrib><creatorcontrib>Walter, Glenn A.</creatorcontrib><creatorcontrib>Vandenborne, Krista</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lott, Donovan J.</au><au>Taivassalo, Tanja</au><au>Cooke, Korey D.</au><au>Park, Hyunjun</au><au>Moslemi, Zahra</au><au>Batra, Abhinandan</au><au>Forbes, Sean C.</au><au>Byrne, Barry J.</au><au>Walter, Glenn A.</au><au>Vandenborne, Krista</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy</atitle><jtitle>Muscle & nerve</jtitle><stitle>MUSCLE NERVE</stitle><addtitle>Muscle Nerve</addtitle><date>2021-03</date><risdate>2021</risdate><volume>63</volume><issue>3</issue><spage>320</spage><epage>326</epage><pages>320-326</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Background
This two‐part study explored the safety, feasibility, and efficacy of a mild–moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD).
Methods
First, we used a dose escalation paradigm with varying intensity and frequency of leg isometric exercise to determine the dose response and safety in 10 boys. Second, we examined safety and feasibility of a 12‐wk in‐home, remotely supervised, mild–moderate intensity strengthening program in eight boys. Safety measures included T2 MRI, creatine kinase levels, and pain. Peak strength and function (time to ascend/descend four stairs) were also measured.
Results
Dose‐escalation revealed no signs of muscle damage. Seven of the eight boys completed the 12‐wk in‐home program with a compliance of 84.9%, no signs of muscle damage, and improvements in strength (knee extensors P < .01; knee flexors P < .05) and function (descending steps P < .05).
Conclusions
An in‐home, mild–moderate intensity leg exercise program is safe with potential to positively impact both strength and function in ambulatory boys with DMD.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33295018</pmid><doi>10.1002/mus.27137</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7302-1756</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-639X |
| ispartof | Muscle & nerve, 2021-03, Vol.63 (3), p.320-326 |
| issn | 0148-639X 1097-4598 |
| language | eng |
| recordid | cdi_wiley_primary_10_1002_mus_27137_MUS27137 |
| source | MEDLINE; Access via Wiley Online Library; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Child Clinical Neurology Creatine Creatine kinase Creatine Kinase - blood Damage Duchenne muscular dystrophy Duchenne's muscular dystrophy Dystrophy Exercise Exercise Therapy - methods Feasibility Studies Flexors functional ability Hamstring Muscles - diagnostic imaging Humans in‐home exercise program isometric exercise Kinases Knee Leg Life Sciences & Biomedicine Magnetic Resonance Imaging Male Muscle contraction Muscle Strength Muscle, Skeletal - diagnostic imaging Muscles Muscular dystrophy Muscular Dystrophy, Duchenne - blood Muscular Dystrophy, Duchenne - diagnostic imaging Muscular Dystrophy, Duchenne - rehabilitation Neurosciences Neurosciences & Neurology Pain Quadriceps Muscle - diagnostic imaging Safety Safety measures Science & Technology Stairways Strengthening T2 MRI Treatment Outcome |
| title | Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T13%3A12%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_wiley&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Safety,%20feasibility,%20and%20efficacy%20of%20strengthening%20exercise%20in%20Duchenne%20muscular%20dystrophy&rft.jtitle=Muscle%20&%20nerve&rft.au=Lott,%20Donovan%20J.&rft.date=2021-03&rft.volume=63&rft.issue=3&rft.spage=320&rft.epage=326&rft.pages=320-326&rft.issn=0148-639X&rft.eissn=1097-4598&rft_id=info:doi/10.1002/mus.27137&rft_dat=%3Cproquest_wiley%3E2468666389%3C/proquest_wiley%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2490397520&rft_id=info:pmid/33295018&rfr_iscdi=true |