Effects of humidity and temperature on in vitro dissolution of carbamazepine tablets

Effects of humidity and temperature on in vitro dissolution of carbamazepine tablets

The rate and extent of dissolution of various approved marketed carbamazepine (CBZ) tablets exposed to 33, 52, 75, and 97% relative humidities at both room temperature and 40 °C, and saturated water vapor at room temperature were compared to fresh unstressed tablets. The dissolution data indicate th...

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Veröffentlicht in:Journal of pharmaceutical sciences 1993-10, Vol.82 (10), p.1002-1005
Hauptverfasser: Wang, Jin Tsai, Shiu, Gerald K., Ong-Chen, Ting, Viswanathan, C. T., Skelly, Jerome P.
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container_end_page 1005
container_issue 10
container_start_page 1002
container_title Journal of pharmaceutical sciences
container_volume 82
creator Wang, Jin Tsai
Shiu, Gerald K.
Ong-Chen, Ting
Viswanathan, C. T.
Skelly, Jerome P.
description The rate and extent of dissolution of various approved marketed carbamazepine (CBZ) tablets exposed to 33, 52, 75, and 97% relative humidities at both room temperature and 40 °C, and saturated water vapor at room temperature were compared to fresh unstressed tablets. The dissolution data indicate that exposure of CBZ tabiets to high humidity and temperature can have a profound effect on tablet disintegration and dissolution. The dissolution rates of some batches of CBZ products exposed to 97% humidity at 40 °C or saturated water vapor at room temperature were drastically reduced in only 6–7 days.
doi_str_mv 10.1002/jps.2600821006
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title Effects of humidity and temperature on in vitro dissolution of carbamazepine tablets
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