Distribution and fate of diethyl malonate and dilsopropyl fluorophosphate on pig skin in vitro

The in vitro distribution and fate of [14C]diethyl malonate and [14C]diisopropyl fluorophosphate were evaluated on normal and heat‐treated pig skin. The extent of hydrolysis from the skin surface, skin, and receptor fluid was determined. A significant skin‐mediated hydrolysis (15–35% of applied dose...

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Veröffentlicht in:Journal of pharmaceutical sciences 1988-10, Vol.77 (10), p.850-854
Hauptverfasser: Chellquist, Eric M., Reifenrath, William G.
Format: Artikel
Sprache:eng
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