High yield synthesis of 4H-1,4-benzothiazine-1,1-dioxide derivatives

High yield synthesis of 4H-1,4-benzothiazine-1,1-dioxide derivatives

4H‐1,4‐Benzothiazine‐1,1‐dioxide derivatives were synthesized through a sequence of almost quantitative reactions. The commercial starting material 2‐(methylsulfanyl)aniline was Boc‐protected, N‐acylated and oxidized at the sulfur atom to obtain a sulfonyl derivative. An anionic transposition of the...

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Veröffentlicht in:Journal of heterocyclic chemistry 2008-09, Vol.45 (5), p.1445-1449
Hauptverfasser: De Montis, Stefania, Fattuoni, Claudia, Cadoni, Enzo, Cabiddu, Maria G., Usai, Michele, Cabiddu, Salvatore
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container_end_page 1449
container_issue 5
container_start_page 1445
container_title Journal of heterocyclic chemistry
container_volume 45
creator De Montis, Stefania
Fattuoni, Claudia
Cadoni, Enzo
Cabiddu, Maria G.
Usai, Michele
Cabiddu, Salvatore
description 4H‐1,4‐Benzothiazine‐1,1‐dioxide derivatives were synthesized through a sequence of almost quantitative reactions. The commercial starting material 2‐(methylsulfanyl)aniline was Boc‐protected, N‐acylated and oxidized at the sulfur atom to obtain a sulfonyl derivative. An anionic transposition of the acyl group followed by asimultaneous deprotection‐cyclization gave the title products in excellent yields. All products and intermediates were fully characterized.
doi_str_mv 10.1002/jhet.5570450530
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title High yield synthesis of 4H-1,4-benzothiazine-1,1-dioxide derivatives
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