Synthesis and antibacterial screening of new 4-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylthio)methyl)tetrazolo[1,5-a]quinoline derivatives
A method for the synthesis of previously unknown heterocyclic systems 4‐((5‐(difluoromethoxy)‐1H‐benzo[d]imidazol‐2‐ylthio)methyl)tetrazolo[1,5‐a]quinolines derivatives 6 has been developed based on various substitutes 2‐chloroquinoline‐3‐carbaldehydes 1 via the consecutive steps of conversion into...
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| Veröffentlicht in: | Journal of heterocyclic chemistry 2010-03, Vol.47 (2), p.441-445 |
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| container_end_page | 445 |
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| container_issue | 2 |
| container_start_page | 441 |
| container_title | Journal of heterocyclic chemistry |
| container_volume | 47 |
| creator | Sonar, Swapnil S. Sadaphal, Sandip A. Pokalwar, Rajkumar U. Shingate, Bapurao B. Shingare, Murlidhar S. |
| description | A method for the synthesis of previously unknown heterocyclic systems 4‐((5‐(difluoromethoxy)‐1H‐benzo[d]imidazol‐2‐ylthio)methyl)tetrazolo[1,5‐a]quinolines derivatives 6 has been developed based on various substitutes 2‐chloroquinoline‐3‐carbaldehydes 1 via the consecutive steps of conversion into tetrazolo[1,5‐a]quinoline‐4‐carbaldehyde 2 on treatment with sodium azide which upon reduction to the corresponding alcohol derivatives 3, conversion to chlorides 4 with thionyl chloride followed by the coupling with 5‐(difluoromethoxy)‐1H‐benzo[d]imidazole‐2‐thiol 5. The synthesized titled compounds (6a, 6b, 6c, 6d, 6e) were screened for the antibacterial activity against gram positive and gram negative bacteria. J. Heterocyclic Chem., (2010). |
| doi_str_mv | 10.1002/jhet.340 |
| format | Article |
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| source | Wiley Online Library All Journals |
| title | Synthesis and antibacterial screening of new 4-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylthio)methyl)tetrazolo[1,5-a]quinoline derivatives |
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