Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
Objective The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 2020-10, Vol.34 (10), p.e23618-n/a, Article 23618 |
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| creator | Cheng, Linlin Li, Haolong Li, Liubing Liu, Chenxi Yan, Songxin Chen, Haizhen Li, Yongzhe |
| description | Objective
The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin in COVID‐19.
Methods
Studies investigating ferritin in COVID‐19 were collected from PubMed, EMBASE, CNKI, SinoMed, and WANFANG. A meta‐analysis was performed to compare the ferritin level between different patient groups: non‐survivors versus survivors; more severe versus less severe; with comorbidity versus without comorbidity; ICU versus non‐ICU; with mechanical ventilation versus without mechanical ventilation.
Results
A total of 52 records involving 10 614 COVID‐19‐confirmed patients between December 25, 2019, and June 1, 2020, were included in this meta‐analysis, and 18 studies were included in the qualitative synthesis. The ferritin level was significantly increased in severe patients compared with the level in non‐severe patients [WMD 397.77 (95% CI 306.51‐489.02), P |
| doi_str_mv | 10.1002/jcla.23618 |
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| fullrecord | <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_wiley_primary_10_1002_jcla_23618_JCLA23618</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2455646150</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5148-c649cdde622d9471abeab1f58ae41e10b50401f35debe9cf373efc7396af48563</originalsourceid><addsrcrecordid>eNqNkcFu1DAURS0EokNhwwcgS2wKKOU5jhObBdIoUCgaqRtgieU4L9SjTNzayVSz4xP4Rr4ET2cYAQuEZckLn3d17UPIYwanDCB_ubS9Oc15yeQdMmOgZJbLXNwlM5CyyiQwfkQexLgEAKlYeZ8ccQ6VLABm5MsZhuBGN9C0x0uk1gc_mLULU6Sti2gi0hyYoif1xefzNz--fWfq2Ss6p3ETR1yZ0VkacO3whpqhpSscTWLMYPpNdPEhudeZPuKj_XlMPp29_Vi_zxYX787r-SKzghUys2WhbNtimeetKipmGjQN64Q0WDBk0AgogHVctNigsh2vOHa24qo0XSFFyY_J613u1dSssLU4jMH0-iq4lQkb7Y3Tf94M7lJ_9WtdCSUUUyngZB8Q_PWEcdQrFy32vRnQT1HnhcgFVFxUCX36F7r0U0gPvqVEWZRMQKKe7ygbfIwBu0MZBnqrTW-16VttCX7ye_0D-stTAl7sgBtsfBetw8HiAUtiRaXSD8F2sUTL_6drNyaJfqj9NIxplO1HXY-bf3TWH-rFfNf-J2QoxFQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2455646150</pqid></control><display><type>article</type><title>Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Access via Wiley Online Library</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><creator>Cheng, Linlin ; Li, Haolong ; Li, Liubing ; Liu, Chenxi ; Yan, Songxin ; Chen, Haizhen ; Li, Yongzhe</creator><creatorcontrib>Cheng, Linlin ; Li, Haolong ; Li, Liubing ; Liu, Chenxi ; Yan, Songxin ; Chen, Haizhen ; Li, Yongzhe</creatorcontrib><description>Objective
The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin in COVID‐19.
Methods
Studies investigating ferritin in COVID‐19 were collected from PubMed, EMBASE, CNKI, SinoMed, and WANFANG. A meta‐analysis was performed to compare the ferritin level between different patient groups: non‐survivors versus survivors; more severe versus less severe; with comorbidity versus without comorbidity; ICU versus non‐ICU; with mechanical ventilation versus without mechanical ventilation.
Results
A total of 52 records involving 10 614 COVID‐19‐confirmed patients between December 25, 2019, and June 1, 2020, were included in this meta‐analysis, and 18 studies were included in the qualitative synthesis. The ferritin level was significantly increased in severe patients compared with the level in non‐severe patients [WMD 397.77 (95% CI 306.51‐489.02), P < .001]. Non‐survivors had a significantly higher ferritin level compared with the one in survivors [WMD 677.17 (95% CI 391.01‐963.33), P < .001]. Patients with one or more comorbidities including diabetes, thrombotic complication, and cancer had significantly higher levels of ferritin than those without (P < .01). Severe acute liver injury was significantly associated with high levels of ferritin, and its level was associated with intensive supportive care, including ICU transfer and mechanical ventilation.
Conclusions
Ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients.
Serum ferritin resulted as a valuable biomarker in COVID‐19. Indeed, this meta‐analysis revealed the association between the serum ferritin level and clinical characteristics of COVID‐19 patients including disease severity, mortality, comorbidities, and certain treatment. Thus, ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients.</description><identifier>ISSN: 0887-8013</identifier><identifier>ISSN: 1098-2825</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.23618</identifier><identifier>PMID: 33078400</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Anemia ; Betacoronavirus ; Comorbidity ; Coronaviridae ; Coronavirus Infections - blood ; Coronavirus Infections - diagnosis ; Coronavirus Infections - epidemiology ; Coronavirus Infections - mortality ; Coronaviruses ; COVID-19 ; Cytokine storm ; Cytokines ; Diabetes mellitus ; diagnosis ; Disease transmission ; Female ; Ferritin ; Ferritins - blood ; Histiocytosis ; Humans ; Ischemia ; Laboratories ; Life Sciences & Biomedicine ; Lymphocytosis ; Male ; Mechanical ventilation ; Medical Laboratory Technology ; Meta-analysis ; Middle Aged ; Mortality ; Pandemics ; Patients ; Pneumonia, Viral - blood ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - mortality ; Prognosis ; Review ; SARS-CoV-2 ; Science & Technology ; severity ; Ventilators</subject><ispartof>Journal of clinical laboratory analysis, 2020-10, Vol.34 (10), p.e23618-n/a, Article 23618</ispartof><rights>2020 The Authors. Published by Wiley Periodicals LLC</rights><rights>2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals LLC.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>223</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000579401000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c5148-c649cdde622d9471abeab1f58ae41e10b50401f35debe9cf373efc7396af48563</citedby><cites>FETCH-LOGICAL-c5148-c649cdde622d9471abeab1f58ae41e10b50401f35debe9cf373efc7396af48563</cites><orcidid>0000-0001-7154-1021 ; 0000-0003-1924-3363 ; 0000-0001-9663-9607</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595919/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595919/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,1418,2115,11567,27929,27930,28253,45579,45580,46057,46481,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33078400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Linlin</creatorcontrib><creatorcontrib>Li, Haolong</creatorcontrib><creatorcontrib>Li, Liubing</creatorcontrib><creatorcontrib>Liu, Chenxi</creatorcontrib><creatorcontrib>Yan, Songxin</creatorcontrib><creatorcontrib>Chen, Haizhen</creatorcontrib><creatorcontrib>Li, Yongzhe</creatorcontrib><title>Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis</title><title>Journal of clinical laboratory analysis</title><addtitle>J CLIN LAB ANAL</addtitle><addtitle>J Clin Lab Anal</addtitle><description>Objective
The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin in COVID‐19.
Methods
Studies investigating ferritin in COVID‐19 were collected from PubMed, EMBASE, CNKI, SinoMed, and WANFANG. A meta‐analysis was performed to compare the ferritin level between different patient groups: non‐survivors versus survivors; more severe versus less severe; with comorbidity versus without comorbidity; ICU versus non‐ICU; with mechanical ventilation versus without mechanical ventilation.
Results
A total of 52 records involving 10 614 COVID‐19‐confirmed patients between December 25, 2019, and June 1, 2020, were included in this meta‐analysis, and 18 studies were included in the qualitative synthesis. The ferritin level was significantly increased in severe patients compared with the level in non‐severe patients [WMD 397.77 (95% CI 306.51‐489.02), P < .001]. Non‐survivors had a significantly higher ferritin level compared with the one in survivors [WMD 677.17 (95% CI 391.01‐963.33), P < .001]. Patients with one or more comorbidities including diabetes, thrombotic complication, and cancer had significantly higher levels of ferritin than those without (P < .01). Severe acute liver injury was significantly associated with high levels of ferritin, and its level was associated with intensive supportive care, including ICU transfer and mechanical ventilation.
Conclusions
Ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients.
Serum ferritin resulted as a valuable biomarker in COVID‐19. Indeed, this meta‐analysis revealed the association between the serum ferritin level and clinical characteristics of COVID‐19 patients including disease severity, mortality, comorbidities, and certain treatment. Thus, ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anemia</subject><subject>Betacoronavirus</subject><subject>Comorbidity</subject><subject>Coronaviridae</subject><subject>Coronavirus Infections - blood</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronavirus Infections - mortality</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cytokine storm</subject><subject>Cytokines</subject><subject>Diabetes mellitus</subject><subject>diagnosis</subject><subject>Disease transmission</subject><subject>Female</subject><subject>Ferritin</subject><subject>Ferritins - blood</subject><subject>Histiocytosis</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Life Sciences & Biomedicine</subject><subject>Lymphocytosis</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medical Laboratory Technology</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Pneumonia, Viral - blood</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Pneumonia, Viral - mortality</subject><subject>Prognosis</subject><subject>Review</subject><subject>SARS-CoV-2</subject><subject>Science & Technology</subject><subject>severity</subject><subject>Ventilators</subject><issn>0887-8013</issn><issn>1098-2825</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkcFu1DAURS0EokNhwwcgS2wKKOU5jhObBdIoUCgaqRtgieU4L9SjTNzayVSz4xP4Rr4ET2cYAQuEZckLn3d17UPIYwanDCB_ubS9Oc15yeQdMmOgZJbLXNwlM5CyyiQwfkQexLgEAKlYeZ8ccQ6VLABm5MsZhuBGN9C0x0uk1gc_mLULU6Sti2gi0hyYoif1xefzNz--fWfq2Ss6p3ETR1yZ0VkacO3whpqhpSscTWLMYPpNdPEhudeZPuKj_XlMPp29_Vi_zxYX787r-SKzghUys2WhbNtimeetKipmGjQN64Q0WDBk0AgogHVctNigsh2vOHa24qo0XSFFyY_J613u1dSssLU4jMH0-iq4lQkb7Y3Tf94M7lJ_9WtdCSUUUyngZB8Q_PWEcdQrFy32vRnQT1HnhcgFVFxUCX36F7r0U0gPvqVEWZRMQKKe7ygbfIwBu0MZBnqrTW-16VttCX7ye_0D-stTAl7sgBtsfBetw8HiAUtiRaXSD8F2sUTL_6drNyaJfqj9NIxplO1HXY-bf3TWH-rFfNf-J2QoxFQ</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Cheng, Linlin</creator><creator>Li, Haolong</creator><creator>Li, Liubing</creator><creator>Liu, Chenxi</creator><creator>Yan, Songxin</creator><creator>Chen, Haizhen</creator><creator>Li, Yongzhe</creator><general>Wiley</general><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7154-1021</orcidid><orcidid>https://orcid.org/0000-0003-1924-3363</orcidid><orcidid>https://orcid.org/0000-0001-9663-9607</orcidid></search><sort><creationdate>202010</creationdate><title>Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis</title><author>Cheng, Linlin ; Li, Haolong ; Li, Liubing ; Liu, Chenxi ; Yan, Songxin ; Chen, Haizhen ; Li, Yongzhe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5148-c649cdde622d9471abeab1f58ae41e10b50401f35debe9cf373efc7396af48563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anemia</topic><topic>Betacoronavirus</topic><topic>Comorbidity</topic><topic>Coronaviridae</topic><topic>Coronavirus Infections - blood</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronavirus Infections - mortality</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cytokine storm</topic><topic>Cytokines</topic><topic>Diabetes mellitus</topic><topic>diagnosis</topic><topic>Disease transmission</topic><topic>Female</topic><topic>Ferritin</topic><topic>Ferritins - blood</topic><topic>Histiocytosis</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Life Sciences & Biomedicine</topic><topic>Lymphocytosis</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Medical Laboratory Technology</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Pneumonia, Viral - blood</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - epidemiology</topic><topic>Pneumonia, Viral - mortality</topic><topic>Prognosis</topic><topic>Review</topic><topic>SARS-CoV-2</topic><topic>Science & Technology</topic><topic>severity</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Linlin</creatorcontrib><creatorcontrib>Li, Haolong</creatorcontrib><creatorcontrib>Li, Liubing</creatorcontrib><creatorcontrib>Liu, Chenxi</creatorcontrib><creatorcontrib>Yan, Songxin</creatorcontrib><creatorcontrib>Chen, Haizhen</creatorcontrib><creatorcontrib>Li, Yongzhe</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Linlin</au><au>Li, Haolong</au><au>Li, Liubing</au><au>Liu, Chenxi</au><au>Yan, Songxin</au><au>Chen, Haizhen</au><au>Li, Yongzhe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><stitle>J CLIN LAB ANAL</stitle><addtitle>J Clin Lab Anal</addtitle><date>2020-10</date><risdate>2020</risdate><volume>34</volume><issue>10</issue><spage>e23618</spage><epage>n/a</epage><pages>e23618-n/a</pages><artnum>23618</artnum><issn>0887-8013</issn><issn>1098-2825</issn><eissn>1098-2825</eissn><abstract>Objective
The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin in COVID‐19.
Methods
Studies investigating ferritin in COVID‐19 were collected from PubMed, EMBASE, CNKI, SinoMed, and WANFANG. A meta‐analysis was performed to compare the ferritin level between different patient groups: non‐survivors versus survivors; more severe versus less severe; with comorbidity versus without comorbidity; ICU versus non‐ICU; with mechanical ventilation versus without mechanical ventilation.
Results
A total of 52 records involving 10 614 COVID‐19‐confirmed patients between December 25, 2019, and June 1, 2020, were included in this meta‐analysis, and 18 studies were included in the qualitative synthesis. The ferritin level was significantly increased in severe patients compared with the level in non‐severe patients [WMD 397.77 (95% CI 306.51‐489.02), P < .001]. Non‐survivors had a significantly higher ferritin level compared with the one in survivors [WMD 677.17 (95% CI 391.01‐963.33), P < .001]. Patients with one or more comorbidities including diabetes, thrombotic complication, and cancer had significantly higher levels of ferritin than those without (P < .01). Severe acute liver injury was significantly associated with high levels of ferritin, and its level was associated with intensive supportive care, including ICU transfer and mechanical ventilation.
Conclusions
Ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients.
Serum ferritin resulted as a valuable biomarker in COVID‐19. Indeed, this meta‐analysis revealed the association between the serum ferritin level and clinical characteristics of COVID‐19 patients including disease severity, mortality, comorbidities, and certain treatment. Thus, ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>33078400</pmid><doi>10.1002/jcla.23618</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0001-7154-1021</orcidid><orcidid>https://orcid.org/0000-0003-1924-3363</orcidid><orcidid>https://orcid.org/0000-0001-9663-9607</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Aged, 80 and over Anemia Betacoronavirus Comorbidity Coronaviridae Coronavirus Infections - blood Coronavirus Infections - diagnosis Coronavirus Infections - epidemiology Coronavirus Infections - mortality Coronaviruses COVID-19 Cytokine storm Cytokines Diabetes mellitus diagnosis Disease transmission Female Ferritin Ferritins - blood Histiocytosis Humans Ischemia Laboratories Life Sciences & Biomedicine Lymphocytosis Male Mechanical ventilation Medical Laboratory Technology Meta-analysis Middle Aged Mortality Pandemics Patients Pneumonia, Viral - blood Pneumonia, Viral - diagnosis Pneumonia, Viral - epidemiology Pneumonia, Viral - mortality Prognosis Review SARS-CoV-2 Science & Technology severity Ventilators |
| title | Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis |
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