Regulation of lysyl oxidase expression in THP‐1 cell‐derived M2‐like macrophages

Lysyl oxidase (LOX) is a copper‐containing enzyme and its overexpression in tumor tissues promote tumor metastasis through the crosslinking of extracellular matrix. Our previous report demonstrated that LOX expression is significantly increased in human leukemic THP‐1 cell‐derived M2‐like macrophage...

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Veröffentlicht in:	Journal of cellular biochemistry 2021-08, Vol.122 (8), p.777-786
Hauptverfasser:	Takemoto, Ryuhei, Kamiya, Tetsuro, Atobe, Taku, Hara, Hirokazu, Adachi, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biochemistry & Molecular Biology Cell Biology Crosslinking Extracellular matrix Forkhead protein FOXO1 FOXO1 protein HIF1α Histones Hypoxia Inhibitors Leukemia Life Sciences & Biomedicine Liquid oxygen Lysyl oxidase macrophage Macrophages Metastases Oxidase Science & Technology STAT3 Stat3 protein Transcription factors tumor microenvironment Tumors
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