A Different Role of Meldrum's Acid in the Biginelli Reaction
A Biginelli‐type condensation using Meldrum's acid has been accomplished in refluxing AcOH to give 6‐substituted dihydropyrimidine‐2,4‐(1H,3H)‐diones. In contrast to other aldehydes, the three‐component reaction with salicylaldehyde led to an oxygen‐bridged pyridine. A reaction mechanism is pro...
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| Veröffentlicht in: | Helvetica chimica acta 2011-02, Vol.94 (2), p.199-205 |
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| container_title | Helvetica chimica acta |
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| creator | Svĕtlík, Jan Veizerová, Lucia |
| description | A Biginelli‐type condensation using Meldrum's acid has been accomplished in refluxing AcOH to give 6‐substituted dihydropyrimidine‐2,4‐(1H,3H)‐diones. In contrast to other aldehydes, the three‐component reaction with salicylaldehyde led to an oxygen‐bridged pyridine. A reaction mechanism is proposed. |
| doi_str_mv | 10.1002/hlca.201000193 |
| format | Article |
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In contrast to other aldehydes, the three‐component reaction with salicylaldehyde led to an oxygen‐bridged pyridine. 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A reaction mechanism is proposed.</description><subject>Biginelli reaction</subject><subject>Meldrum's acid</subject><subject>Multicomponent reaction</subject><subject>oxygen-bridged</subject><subject>Pyridine</subject><subject>Pyridine, oxygen‐bridged</subject><subject>Salicylaldehyde</subject><issn>0018-019X</issn><issn>1522-2675</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNo9j01PwzAMhiMEEmNw5Zwbp458NE0jcSnd2JDGgAoE4hK1qcMCWYvaIti_p9NQT7Zf-bH8IHROyYQSwi7X3uQTRvqeUMUP0IgKxgIWSXGIRn0WB33-eoxO2vaj31GKyBG6SvDUWQsNVB3Oag-4tvgOfNl8by5anBhXYlfhbg342r27Crx3OIPcdK6uTtGRzX0LZ_91jJ5vZk_pIljez2_TZBk4FnIeCFFGxBgQMRimiohGtii5tECVMSqWhaWmf0cqS8owtDSMhTJCSpqDJaaUfIzU_u6P87DVX43b5M1WU6J34nonrgdxvVimyTD1bLBnXdvB78DmzaeOJJdCv6zm-o1Ow9UDedQZ_wNU6Vzs</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Svĕtlík, Jan</creator><creator>Veizerová, Lucia</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope></search><sort><creationdate>201102</creationdate><title>A Different Role of Meldrum's Acid in the Biginelli Reaction</title><author>Svĕtlík, Jan ; Veizerová, Lucia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2433-55d60cce58ec29b616fbd37fe19cc987bf1c09979f0d44f14859c5771aef0cd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biginelli reaction</topic><topic>Meldrum's acid</topic><topic>Multicomponent reaction</topic><topic>oxygen-bridged</topic><topic>Pyridine</topic><topic>Pyridine, oxygen‐bridged</topic><topic>Salicylaldehyde</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Svĕtlík, Jan</creatorcontrib><creatorcontrib>Veizerová, Lucia</creatorcontrib><collection>Istex</collection><jtitle>Helvetica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Svĕtlík, Jan</au><au>Veizerová, Lucia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Different Role of Meldrum's Acid in the Biginelli Reaction</atitle><jtitle>Helvetica chimica acta</jtitle><addtitle>HCA</addtitle><date>2011-02</date><risdate>2011</risdate><volume>94</volume><issue>2</issue><spage>199</spage><epage>205</epage><pages>199-205</pages><issn>0018-019X</issn><eissn>1522-2675</eissn><abstract>A Biginelli‐type condensation using Meldrum's acid has been accomplished in refluxing AcOH to give 6‐substituted dihydropyrimidine‐2,4‐(1H,3H)‐diones. In contrast to other aldehydes, the three‐component reaction with salicylaldehyde led to an oxygen‐bridged pyridine. A reaction mechanism is proposed.</abstract><cop>Zürich</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/hlca.201000193</doi><tpages>7</tpages></addata></record> |
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| ispartof | Helvetica chimica acta, 2011-02, Vol.94 (2), p.199-205 |
| issn | 0018-019X 1522-2675 |
| language | eng |
| recordid | cdi_wiley_primary_10_1002_hlca_201000193_HLCA201000193 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biginelli reaction Meldrum's acid Multicomponent reaction oxygen-bridged Pyridine Pyridine, oxygen‐bridged Salicylaldehyde |
| title | A Different Role of Meldrum's Acid in the Biginelli Reaction |
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