Synthese eines hochwirksamen Hypertensin II‐amids (L‐Asparaginyl‐L‐arginyl‐L‐valyl‐L‐tyrosyl‐L‐isoleucyl‐L‐histidyl‐L‐prolyl‐L‐phenylalanin)

The synthesis of Ileu5‐hypertensin II‐Asp‐β‐amide, L‐Asparaginyl‐L‐arginyl‐L‐valyl‐L‐tyrosyl‐L‐isoleucyl‐L‐histidyl‐L‐prolyl‐L‐phenylalanine, is described. The highly purified octapeptide is 5 to 10 times as active as noradrenaline on the blood pressure of the rat in the experimental set‐up of Peart9), and 2 to 4 times as active as Val5‐ hypertensin I, isolated from bovine plasma3).