Electrochemical Behaviour of the Anticancer Dacarbazine-Cu2+ Complex and Its Analytical Applications

Electrochemical reduction of the dacarbazine‐Cu2+ complex was investigated using cyclic voltammetry and square wave voltammetry at a hanging mercury drop electrode. The reduction of the dacarbazine‐Cu2+ complex is irreversible. A reduction mechanism is proposed comprising a one‐electron reduction of...

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Veröffentlicht in:	Electroanalysis (New York, N.Y.) N.Y.), 2011-07, Vol.23 (7), p.1638-1644
Hauptverfasser:	Temerk, Yassien M., Kamal, Moustafa M., Ibrahim, Mohamed S., Ibrahim, Hossieny S. M., Schuhmann, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer drug Dacarbazine Dacarbazine copper complex HMDE Voltammetry Voltammetry HMDE
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creator	Temerk, Yassien M. Kamal, Moustafa M. Ibrahim, Mohamed S. Ibrahim, Hossieny S. M. Schuhmann, Wolfgang
description	Electrochemical reduction of the dacarbazine‐Cu2+ complex was investigated using cyclic voltammetry and square wave voltammetry at a hanging mercury drop electrode. The reduction of the dacarbazine‐Cu2+ complex is irreversible. A reduction mechanism is proposed comprising a one‐electron reduction of the Cu2+ directly within the complex. The sharp peak of the adsorbed dacarbazine‐Cu2+ complex associated with an effective interfacial accumulation facilitates the determination of the anticancer drug dacarbazine in pharmaceutical formulations and biological fluids. Detection limits for dacarbazine of 6.12×10−10 M, 1.57×10−10 M and 1.97×10−9 M were achieved for the determination of the drug in vial, human urine and serum, respectively.
doi_str_mv	10.1002/elan.201100038
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subjects	Anticancer drug Dacarbazine Dacarbazine copper complex HMDE Voltammetry Voltammetry HMDE
title	Electrochemical Behaviour of the Anticancer Dacarbazine-Cu2+ Complex and Its Analytical Applications
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