Immune recognition of insulin by H‐2b mice: the mutation in the I‐A βb gene of the B6.C‐H‐2bm12 mouse alters the self‐I‐A‐restricted T cell repertoire

The response to heterologous insulin in H‐2b mice is restricted to the A chain loop determinant(s) of beef insulin. The recognition of this specificity requires the expression of the immune response (Ir) gene epitope Ia. W39 which is absent from the I‐Ab mutant B6.C‐H‐2bm12 (bm12) mice. This restric...

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Veröffentlicht in:	European journal of immunology 1984, Vol.14 (7), p.610-615
Hauptverfasser:	Hochman, Paula S., Huber, Brigitte T.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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