Particle radiation therapy in the management of malignant glioma: Early experience at the Shanghai Proton and Heavy Ion Center

Background The objective of this study was to evaluate the outcomes of patients with high‐grade glioma who received treatment with particle radiotherapy. Methods Between June 2015 and October 2018, 50 consecutive and nonselected patients with glioblastoma multiforme (n = 34) or anaplastic glioma (n ...

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Veröffentlicht in:	Cancer 2020-06, Vol.126 (12), p.2802-2810
Hauptverfasser:	Kong, Lin, Wu, Jinsong, Gao, Jing, Qiu, Xianxin, Yang, Jing, Hu, Jiyi, Hu, Weixu, Mao, Ying, Lu, Jiade J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Antineoplastic Agents, Alkylating - therapeutic use DNA methylation DNA methyltransferase DNA Modification Methylases - metabolism DNA Repair Enzymes - metabolism Dose Fractionation, Radiation Early experience Equivalence Female Glioblastoma Glioblastoma - drug therapy Glioblastoma - mortality Glioblastoma - pathology Glioblastoma - radiotherapy Glioma Glioma - drug therapy Glioma - mortality Glioma - pathology Glioma - radiotherapy Heavy Ion Radiotherapy - adverse effects Heavy Ion Radiotherapy - methods Heavy ions high‐grade glioma Humans Life Sciences & Biomedicine Male Methylguanine Middle Aged Mutation Necrosis O6-methylguanine-DNA methyltransferase Oncology Original particle radiotherapy Proton Therapy - adverse effects Proton Therapy - methods Protons Radiation Radiation effects Radiation therapy Science & Technology Side effects Survival Temozolomide Temozolomide - therapeutic use Toxicity Treatment Outcome Tumor Suppressor Proteins - metabolism Young Adult
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