Front Cover: Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1 (Chem. Eur. J. 56/2024)
Dancing in the dark: Supramolecular binding units mediate specific docking of novel linker systems to lock the ligands’ jaws on the target protease Taspase1. Molecular tweezers were connected by aggregation‐induced emission (AIE) functionalities to generate spider‐like inhibitors lighting up upon pr...
Gespeichert in:
| Veröffentlicht in: | Chemistry : a European journal 2024-10, Vol.30 (56), p.n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 56 |
| container_start_page | |
| container_title | Chemistry : a European journal |
| container_volume | 30 |
| creator | Hommel, Katrin Kauth, Alisa‐Maite A. Kirupakaran, Abbna Theisen, Sebastian Hayduk, Matthias Niemeyer, Felix C. Beuck, Christine Zadmard, Reza Bayer, Peter Jan Ravoo, Bart Voskuhl, Jens Schrader, Thomas Knauer, Shirley K. |
| description | Dancing in the dark: Supramolecular binding units mediate specific docking of novel linker systems to lock the ligands’ jaws on the target protease Taspase1. Molecular tweezers were connected by aggregation‐induced emission (AIE) functionalities to generate spider‐like inhibitors lighting up upon protein binding. Utilizing a calix[4]arene backbone resulted in a scorpion‐like double pincer ligand with even superior binding and enzyme inhibition properties. More information can be found in the Research Article by J. Voskuhl, T. Schrader, S. K. Knauer and co‐workers (DOI: 10.1002/chem.202401542). |
| doi_str_mv | 10.1002/chem.202485601 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley</sourceid><recordid>TN_cdi_wiley_primary_10_1002_chem_202485601_CHEM202485601</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CHEM202485601</sourcerecordid><originalsourceid>FETCH-wiley_primary_10_1002_chem_202485601_CHEM2024856013</originalsourceid><addsrcrecordid>eNqlj0FLwzAYhoMoWJ1Xz99RD-2SZsms19IyxJ3Wewjj24y2SUnSjfnrXWDsD3h6eeF94H0IeWa0YJSW8-0XDkVJy8WbkJTdkIyJkuV8KcUtyWi1WOZS8OqePITwTSmtJOcZGVrvbITaHdC_QzvZbTTO6h4-jf1BH2AzjaPzETrt9xiN3YPbwXrqoznoHs9od0T8TcvozqMw6oAMXup0BprJF_BRgJDzdOx1Ru52ug_4dMlHUrVNV6_yo-nxpEZvBu1PilGVjFQyUlcjVa-a9bXx_7B__XtXnw</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Front Cover: Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1 (Chem. Eur. J. 56/2024)</title><source>Access via Wiley Online Library</source><creator>Hommel, Katrin ; Kauth, Alisa‐Maite A. ; Kirupakaran, Abbna ; Theisen, Sebastian ; Hayduk, Matthias ; Niemeyer, Felix C. ; Beuck, Christine ; Zadmard, Reza ; Bayer, Peter ; Jan Ravoo, Bart ; Voskuhl, Jens ; Schrader, Thomas ; Knauer, Shirley K.</creator><creatorcontrib>Hommel, Katrin ; Kauth, Alisa‐Maite A. ; Kirupakaran, Abbna ; Theisen, Sebastian ; Hayduk, Matthias ; Niemeyer, Felix C. ; Beuck, Christine ; Zadmard, Reza ; Bayer, Peter ; Jan Ravoo, Bart ; Voskuhl, Jens ; Schrader, Thomas ; Knauer, Shirley K.</creatorcontrib><description>Dancing in the dark: Supramolecular binding units mediate specific docking of novel linker systems to lock the ligands’ jaws on the target protease Taspase1. Molecular tweezers were connected by aggregation‐induced emission (AIE) functionalities to generate spider‐like inhibitors lighting up upon protein binding. Utilizing a calix[4]arene backbone resulted in a scorpion‐like double pincer ligand with even superior binding and enzyme inhibition properties. More information can be found in the Research Article by J. Voskuhl, T. Schrader, S. K. Knauer and co‐workers (DOI: 10.1002/chem.202401542).</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.202485601</identifier><language>eng</language><ispartof>Chemistry : a European journal, 2024-10, Vol.30 (56), p.n/a</ispartof><rights>2024 Wiley-VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-7003-6362 ; 0009-0002-6095-5493 ; 0000-0002-3954-9936 ; 0000-0003-2202-7485 ; 0000-0003-4321-0924 ; 0009-0004-6678-8790 ; 0000-0001-7513-7384 ; 0000-0002-9145-773X ; 0000-0001-7563-4911 ; 0000-0003-0435-7202 ; 0000-0002-9612-2306</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.202485601$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.202485601$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Hommel, Katrin</creatorcontrib><creatorcontrib>Kauth, Alisa‐Maite A.</creatorcontrib><creatorcontrib>Kirupakaran, Abbna</creatorcontrib><creatorcontrib>Theisen, Sebastian</creatorcontrib><creatorcontrib>Hayduk, Matthias</creatorcontrib><creatorcontrib>Niemeyer, Felix C.</creatorcontrib><creatorcontrib>Beuck, Christine</creatorcontrib><creatorcontrib>Zadmard, Reza</creatorcontrib><creatorcontrib>Bayer, Peter</creatorcontrib><creatorcontrib>Jan Ravoo, Bart</creatorcontrib><creatorcontrib>Voskuhl, Jens</creatorcontrib><creatorcontrib>Schrader, Thomas</creatorcontrib><creatorcontrib>Knauer, Shirley K.</creatorcontrib><title>Front Cover: Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1 (Chem. Eur. J. 56/2024)</title><title>Chemistry : a European journal</title><description>Dancing in the dark: Supramolecular binding units mediate specific docking of novel linker systems to lock the ligands’ jaws on the target protease Taspase1. Molecular tweezers were connected by aggregation‐induced emission (AIE) functionalities to generate spider‐like inhibitors lighting up upon protein binding. Utilizing a calix[4]arene backbone resulted in a scorpion‐like double pincer ligand with even superior binding and enzyme inhibition properties. More information can be found in the Research Article by J. Voskuhl, T. Schrader, S. K. Knauer and co‐workers (DOI: 10.1002/chem.202401542).</description><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqlj0FLwzAYhoMoWJ1Xz99RD-2SZsms19IyxJ3Wewjj24y2SUnSjfnrXWDsD3h6eeF94H0IeWa0YJSW8-0XDkVJy8WbkJTdkIyJkuV8KcUtyWi1WOZS8OqePITwTSmtJOcZGVrvbITaHdC_QzvZbTTO6h4-jf1BH2AzjaPzETrt9xiN3YPbwXrqoznoHs9od0T8TcvozqMw6oAMXup0BprJF_BRgJDzdOx1Ru52ug_4dMlHUrVNV6_yo-nxpEZvBu1PilGVjFQyUlcjVa-a9bXx_7B__XtXnw</recordid><startdate>20241008</startdate><enddate>20241008</enddate><creator>Hommel, Katrin</creator><creator>Kauth, Alisa‐Maite A.</creator><creator>Kirupakaran, Abbna</creator><creator>Theisen, Sebastian</creator><creator>Hayduk, Matthias</creator><creator>Niemeyer, Felix C.</creator><creator>Beuck, Christine</creator><creator>Zadmard, Reza</creator><creator>Bayer, Peter</creator><creator>Jan Ravoo, Bart</creator><creator>Voskuhl, Jens</creator><creator>Schrader, Thomas</creator><creator>Knauer, Shirley K.</creator><scope/><orcidid>https://orcid.org/0000-0002-7003-6362</orcidid><orcidid>https://orcid.org/0009-0002-6095-5493</orcidid><orcidid>https://orcid.org/0000-0002-3954-9936</orcidid><orcidid>https://orcid.org/0000-0003-2202-7485</orcidid><orcidid>https://orcid.org/0000-0003-4321-0924</orcidid><orcidid>https://orcid.org/0009-0004-6678-8790</orcidid><orcidid>https://orcid.org/0000-0001-7513-7384</orcidid><orcidid>https://orcid.org/0000-0002-9145-773X</orcidid><orcidid>https://orcid.org/0000-0001-7563-4911</orcidid><orcidid>https://orcid.org/0000-0003-0435-7202</orcidid><orcidid>https://orcid.org/0000-0002-9612-2306</orcidid></search><sort><creationdate>20241008</creationdate><title>Front Cover: Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1 (Chem. Eur. J. 56/2024)</title><author>Hommel, Katrin ; Kauth, Alisa‐Maite A. ; Kirupakaran, Abbna ; Theisen, Sebastian ; Hayduk, Matthias ; Niemeyer, Felix C. ; Beuck, Christine ; Zadmard, Reza ; Bayer, Peter ; Jan Ravoo, Bart ; Voskuhl, Jens ; Schrader, Thomas ; Knauer, Shirley K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-wiley_primary_10_1002_chem_202485601_CHEM2024856013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hommel, Katrin</creatorcontrib><creatorcontrib>Kauth, Alisa‐Maite A.</creatorcontrib><creatorcontrib>Kirupakaran, Abbna</creatorcontrib><creatorcontrib>Theisen, Sebastian</creatorcontrib><creatorcontrib>Hayduk, Matthias</creatorcontrib><creatorcontrib>Niemeyer, Felix C.</creatorcontrib><creatorcontrib>Beuck, Christine</creatorcontrib><creatorcontrib>Zadmard, Reza</creatorcontrib><creatorcontrib>Bayer, Peter</creatorcontrib><creatorcontrib>Jan Ravoo, Bart</creatorcontrib><creatorcontrib>Voskuhl, Jens</creatorcontrib><creatorcontrib>Schrader, Thomas</creatorcontrib><creatorcontrib>Knauer, Shirley K.</creatorcontrib><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hommel, Katrin</au><au>Kauth, Alisa‐Maite A.</au><au>Kirupakaran, Abbna</au><au>Theisen, Sebastian</au><au>Hayduk, Matthias</au><au>Niemeyer, Felix C.</au><au>Beuck, Christine</au><au>Zadmard, Reza</au><au>Bayer, Peter</au><au>Jan Ravoo, Bart</au><au>Voskuhl, Jens</au><au>Schrader, Thomas</au><au>Knauer, Shirley K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Front Cover: Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1 (Chem. Eur. J. 56/2024)</atitle><jtitle>Chemistry : a European journal</jtitle><date>2024-10-08</date><risdate>2024</risdate><volume>30</volume><issue>56</issue><epage>n/a</epage><issn>0947-6539</issn><eissn>1521-3765</eissn><abstract>Dancing in the dark: Supramolecular binding units mediate specific docking of novel linker systems to lock the ligands’ jaws on the target protease Taspase1. Molecular tweezers were connected by aggregation‐induced emission (AIE) functionalities to generate spider‐like inhibitors lighting up upon protein binding. Utilizing a calix[4]arene backbone resulted in a scorpion‐like double pincer ligand with even superior binding and enzyme inhibition properties. More information can be found in the Research Article by J. Voskuhl, T. Schrader, S. K. Knauer and co‐workers (DOI: 10.1002/chem.202401542).</abstract><doi>10.1002/chem.202485601</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7003-6362</orcidid><orcidid>https://orcid.org/0009-0002-6095-5493</orcidid><orcidid>https://orcid.org/0000-0002-3954-9936</orcidid><orcidid>https://orcid.org/0000-0003-2202-7485</orcidid><orcidid>https://orcid.org/0000-0003-4321-0924</orcidid><orcidid>https://orcid.org/0009-0004-6678-8790</orcidid><orcidid>https://orcid.org/0000-0001-7513-7384</orcidid><orcidid>https://orcid.org/0000-0002-9145-773X</orcidid><orcidid>https://orcid.org/0000-0001-7563-4911</orcidid><orcidid>https://orcid.org/0000-0003-0435-7202</orcidid><orcidid>https://orcid.org/0000-0002-9612-2306</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0947-6539 |
| ispartof | Chemistry : a European journal, 2024-10, Vol.30 (56), p.n/a |
| issn | 0947-6539 1521-3765 |
| language | eng |
| recordid | cdi_wiley_primary_10_1002_chem_202485601_CHEM202485601 |
| source | Access via Wiley Online Library |
| title | Front Cover: Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1 (Chem. Eur. J. 56/2024) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T05%3A07%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Front%20Cover:%20Functional%20Linkers%20Support%20Targeting%20of%20Multivalent%20Tweezers%20to%20Taspase1%20(Chem.%20Eur.%20J.%2056/2024)&rft.jtitle=Chemistry%20:%20a%20European%20journal&rft.au=Hommel,%20Katrin&rft.date=2024-10-08&rft.volume=30&rft.issue=56&rft.epage=n/a&rft.issn=0947-6539&rft.eissn=1521-3765&rft_id=info:doi/10.1002/chem.202485601&rft_dat=%3Cwiley%3ECHEM202485601%3C/wiley%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |