Simple Synthesis of a Heterocyclophane Exhibiting Anti‐c‐Met Activity by Acting as a Hatch Blocking Access to the Active Site

A simple approach to the synthesis of heterocyclophane consisting of two 4,4’‐bithiazoles has been developed in mild conditions. The heterocyclophane with two short chains was conveniently prepared by Hantzsch thiazoles synthesis using the reaction of 3‐tert‐butoxycarbonyl‐3‐azapentanethiocarboxamid...

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Veröffentlicht in:	Chemistry : a European journal 2021-01, Vol.27 (5), p.1648-1654
Hauptverfasser:	Takimoto, Tatsuya, Sasaki, Hideaki, Tsue, Hirohito, Takahashi, Hiroki, MacKerell, Alexander D., Nakamura, Ayumi, Nakano, Katsuya, Okazaki, Eori, Betsuyaku, Tatsuki, Tachibana, Ryosuke, Hioki, Kazuhito, Yoluk, Ozge, Jo, Sunhwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino groups Chemical synthesis Chemistry computational chemistry Computer applications cyclophanes drug design inhibitors Kinases Mesenchyme Protein kinase inhibitors Proteins synthetic design Thiazoles
Online-Zugang:	Volltext
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