Exploring metabolic responses and pathway changes in CHO‐K1 cells under varied aeration conditions and copper supplementations using 1H NMR‐based metabolomics

The optimization of bioprocess for CHO cell culture involves careful consideration of factors such as nutrient consumption, metabolic byproduct accumulation, cell growth, and monoclonal antibody (mAb) production. Valuable insights can be obtained by understanding cellular physiology to ensure robust...

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Veröffentlicht in:	Biotechnology journal 2024-02, Vol.19 (2), p.n/a
Hauptverfasser:	Shi, Yingting, Wan, Yuxiang, Sun, Yan, Yang, Jiayu, Lu, Yuting, Xie, Xinyuan, Pan, Jianyang, Wang, Haibin, Qu, Haibin
Format:	Artikel
Sprache:	eng
Schlagworte:	1H NMR aeration conditions CHO‐K1 cell culture copper metabolic pathway analysis metabolomics OPLS‐DA
Online-Zugang:	Volltext
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