Structural characterization of rare missense variants within known neurodegenerative disease proteins

Background Recent work suggests unexplained heritability of Alzheimer’s Disease (AD) may involve rare variants in genes implicated in other neurodegenerative disorders. However, existing gene‐based tests have insufficient power to detect true associations when neutral variants are included. Therefor...

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Veröffentlicht in:	Alzheimer's & dementia 2020-12, Vol.16, p.n/a
Hauptverfasser:	Palmer, Ellen L., Moth, Christopher, Benchek, Penelope, Wheeler, Nicholas R., Kunkle, Brian W., Hamilton‐Nelson, Kara L., Griswold, Anthony J., Naj, Adam C., Farrer, Lindsay A., Martin, Eden R., Pericak‐Vance, Margaret A., Haines, Jonathan L., Sheehan, Jonathan H., Capra, John A., Bush, William S.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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