LRP1 mediates tau endocytosis in a process that is modulated by apolipoprotein E

Background Cognitive decline in Alzheimer’s disease correlates with the spreading of neurofibrillary tangles consisting of aggregated forms of tau from the entorhinal cortex to synaptically connected brain regions. It is unclear how tau aggregation propagates across the brain but may involve trans‐s...

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Veröffentlicht in:	Alzheimer's & dementia 2020-12, Vol.16, p.n/a
Hauptverfasser:	Cooper, Joanna M., Migliorini, Mary, Arai, Allison L., Muratoglu, Selen C., Hyman, Bradley T., Strickland, Dudley K.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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