Increased APOE‐e4 expression is associated with reactive A1 astrocytes and may confer the difference in Alzheimer disease risk from different ancestral backgrounds

Background APOEε4 is the strongest genetic risk factor for Alzheimer Disease (AD) in European populations. African local genomic ancestry (LA) surrounding the APOEε4 allele has been associated with a decreased risk for AD in African‐American (AA) carriers relative to European LA in Non‐Hispanic Whit...

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Veröffentlicht in:	Alzheimer's & dementia 2020-12, Vol.16, p.n/a
Hauptverfasser:	Celis, Katrina, Griswold, Anthony J., Bussies, Parker, Rajabli, Farid, Whitehead, Patrice L., Hamilton‐Nelson, Kara L., Beecham, Gary W., Dykxhoorn, Derek M., Nuytemans, Karen, Wang, Liyong, Gardner, Olivia K., Dorfsman, Daniel, Bigio, Eileen H, Mesulam, Marsel, Weintraub, Sandra, Geula, Changiz, Gearing, Marla, Dalgard, Clifton, Mcgrath‐Martinez, Elisa, Scott, William K., Haines, Jonathan L., Pericak‐Vance, Margaret A., Young, Juan, Vance, Jeffery M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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