The aging rhesus macaque as a potential model for Alzheimer's disease/dementia: An in vivo study of [11C]PIB, [11C]UCB‐j, [18F]MK‐6240 and working memory performance

Background Nonhuman primates (NHPs) exhibit age‐related cognitive impairments, synaptic loss, and accumulation of tau and amyloid in dorsolateral prefrontal cortex (dlPFC) and entorhinal cortex (ERC). In a cohort of NHPs with longitudinal cognitive data, we perform SV2A ([11C]UCB‐J), amyloid ([11C]P...

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Veröffentlicht in:	Alzheimer's & dementia 2020-12, Vol.16, p.n/a
Hauptverfasser:	Fang, Xiaotian T., Williams, Graham, Castner, Stacy, Holden, Daniel, Zheng, Ming‐Qiang, Najafzadeh, Soheila, Ropchan, Jim R., Arnsten, Amy F.T., Horvath, Tamas, Carson, Richard E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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