Engineered Matrices Enable the Culture of Human Patient‐Derived Intestinal Organoids

Human intestinal organoids from primary human tissues have the potential to revolutionize personalized medicine and preclinical gastrointestinal disease models. A tunable, fully defined, designer matrix, termed hyaluronan elastin‐like protein (HELP) is reported, which enables the formation, differen...

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Veröffentlicht in:	Advanced science 2021-05, Vol.8 (10), p.2004705-n/a
Hauptverfasser:	Hunt, Daniel R., Klett, Katarina C., Mascharak, Shamik, Wang, Huiyuan, Gong, Diana, Lou, Junzhe, Li, Xingnan, Cai, Pamela C., Suhar, Riley A., Co, Julia Y., LeSavage, Bauer L., Foster, Abbygail A., Guan, Yuan, Amieva, Manuel R., Peltz, Gary, Xia, Yan, Kuo, Calvin J., Heilshorn, Sarah C.
Format:	Artikel
Sprache:	eng
Schlagworte:	3D cell culture adult stem cells Animals Biopolymers Biopsy Cell Differentiation - physiology Cell Survival - physiology Elastin - chemistry engineered biomaterial Epithelial Cells - cytology Epithelial Cells - metabolism extracellular matrix Extracellular Matrix - chemistry Gene expression Humans Hyaluronic acid Hyaluronic Acid - chemistry Hydrogels Intestinal Mucosa - cytology Intestinal Mucosa - metabolism intestinal organoid Ligands Localization Mice Morphology Organoids - cytology Organoids - metabolism Polyethylene glycol Proteins Stem cells Tissue Engineering - methods
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