K2Mn3[FeII(CN)6]2 NPs with High T1‐Relaxivity Attributable to Water Coordination on the Mn(II) Center for Gastrointestinal Tract MR Imaging
The lack of acid stability in the stomach and of temporal stability when moving through the gastrointestinal (GI) tract has made the development of oral magnetic resonance imaging (MRI) contrast agents based on the platform of Gd3+–complexes problematic.On the other hand, the negative contrast enhan...
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| Veröffentlicht in: | Advanced healthcare materials 2021-10, Vol.10 (20), p.n/a |
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| creator | Kandanapitiye, Murthi S. Dassanayake, Thiloka M. Dassanayake, Arosha C. Shelestak, John Clements, Robert J. Fernando, Can Huang, Songping D. |
| description | The lack of acid stability in the stomach and of temporal stability when moving through the gastrointestinal (GI) tract has made the development of oral magnetic resonance imaging (MRI) contrast agents based on the platform of Gd3+–complexes problematic.On the other hand, the negative contrast enhancement produced by the T2‐weighted magnetic metal oxide nanoparticles (NPs) often renders the image readout difficult. Biocompatible NPs of the manganese Prussian blue analog K2Mn3[FeII(CN)6]2 exhibit extremely high stability under the acidic conditions of the gastric juice. Additionally, the high r1 relaxivity, low toxicity, and high temporal stability of such NPs offer great potential for the development of a true T1‐weighted oral contrast agent for MRI of the entire GI tract.
Biocompatible nanoparticles (NPs) of the Mn analog of Prussian blue K2Mn3[FeII(CN)6]2 exhibit extremely high stability under the acidic conditions of the gastric juice. The high r1 relaxivity, low toxicity, and high temporal stability of such NPs offer great potential for the development of a true T1‐weighted oral contrast agent for magnetic resonance imaging of the entire gastrointestinal (GI) tract. |
| doi_str_mv | 10.1002/adhm.202100987 |
| format | Article |
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Biocompatible nanoparticles (NPs) of the Mn analog of Prussian blue K2Mn3[FeII(CN)6]2 exhibit extremely high stability under the acidic conditions of the gastric juice. The high r1 relaxivity, low toxicity, and high temporal stability of such NPs offer great potential for the development of a true T1‐weighted oral contrast agent for magnetic resonance imaging of the entire gastrointestinal (GI) tract.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202100987</identifier><language>eng</language><subject>biocompatible coordination polymers ; contrast agents ; magnetic resonance imaging ; manganese compounds with water coordination ; nanoparticles ; Prussian blue ; relaxivity</subject><ispartof>Advanced healthcare materials, 2021-10, Vol.10 (20), p.n/a</ispartof><rights>2021 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1298-8226</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202100987$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202100987$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids></links><search><creatorcontrib>Kandanapitiye, Murthi S.</creatorcontrib><creatorcontrib>Dassanayake, Thiloka M.</creatorcontrib><creatorcontrib>Dassanayake, Arosha C.</creatorcontrib><creatorcontrib>Shelestak, John</creatorcontrib><creatorcontrib>Clements, Robert J.</creatorcontrib><creatorcontrib>Fernando, Can</creatorcontrib><creatorcontrib>Huang, Songping D.</creatorcontrib><title>K2Mn3[FeII(CN)6]2 NPs with High T1‐Relaxivity Attributable to Water Coordination on the Mn(II) Center for Gastrointestinal Tract MR Imaging</title><title>Advanced healthcare materials</title><description>The lack of acid stability in the stomach and of temporal stability when moving through the gastrointestinal (GI) tract has made the development of oral magnetic resonance imaging (MRI) contrast agents based on the platform of Gd3+–complexes problematic.On the other hand, the negative contrast enhancement produced by the T2‐weighted magnetic metal oxide nanoparticles (NPs) often renders the image readout difficult. Biocompatible NPs of the manganese Prussian blue analog K2Mn3[FeII(CN)6]2 exhibit extremely high stability under the acidic conditions of the gastric juice. Additionally, the high r1 relaxivity, low toxicity, and high temporal stability of such NPs offer great potential for the development of a true T1‐weighted oral contrast agent for MRI of the entire GI tract.
Biocompatible nanoparticles (NPs) of the Mn analog of Prussian blue K2Mn3[FeII(CN)6]2 exhibit extremely high stability under the acidic conditions of the gastric juice. The high r1 relaxivity, low toxicity, and high temporal stability of such NPs offer great potential for the development of a true T1‐weighted oral contrast agent for magnetic resonance imaging of the entire gastrointestinal (GI) tract.</description><subject>biocompatible coordination polymers</subject><subject>contrast agents</subject><subject>magnetic resonance imaging</subject><subject>manganese compounds with water coordination</subject><subject>nanoparticles</subject><subject>Prussian blue</subject><subject>relaxivity</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNo9kM1Kw0AURgdRsNRuXc-yXaTOTzKTLEu0bbCpUiouRMJNM2lG0kQmozU7X0DwGX0SU5ReLtzvwMddHIQuKRlTQtgVZMVuzAjrIPDlCeoxGjCHCS84PWaXnKNB07yQboRHhU976OuWxRV_mqooGobLkXhmeHnf4L22BZ7rbYHX9Ofze6VK-NDv2rZ4Yq3R6ZuFtFTY1vgRrDI4rGuT6QqsrivcrS0UjqthFI1wqKpDI68NnkFjTa07bmxXLvHawMbieIWjHWx1tb1AZzmUjRr83z56mN6sw7mzuJtF4WThNJQR6WS-FEJ4nHkuZyrd5LkI8pQGEgihkLqe8rmSHDyZCeIGmeIKCE9dmUqWUwq8j4K_v3tdqjZ5NXoHpk0oSQ4yk4PM5CgzmVzP4yPxX3Scats</recordid><startdate>20211020</startdate><enddate>20211020</enddate><creator>Kandanapitiye, Murthi S.</creator><creator>Dassanayake, Thiloka M.</creator><creator>Dassanayake, Arosha C.</creator><creator>Shelestak, John</creator><creator>Clements, Robert J.</creator><creator>Fernando, Can</creator><creator>Huang, Songping D.</creator><scope/><orcidid>https://orcid.org/0000-0002-1298-8226</orcidid></search><sort><creationdate>20211020</creationdate><title>K2Mn3[FeII(CN)6]2 NPs with High T1‐Relaxivity Attributable to Water Coordination on the Mn(II) Center for Gastrointestinal Tract MR Imaging</title><author>Kandanapitiye, Murthi S. ; Dassanayake, Thiloka M. ; Dassanayake, Arosha C. ; Shelestak, John ; Clements, Robert J. ; Fernando, Can ; Huang, Songping D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-s1207-d876665325432ebcff69fb197a001ab45e83e73a57d6049de3ea03b47b72f11a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>biocompatible coordination polymers</topic><topic>contrast agents</topic><topic>magnetic resonance imaging</topic><topic>manganese compounds with water coordination</topic><topic>nanoparticles</topic><topic>Prussian blue</topic><topic>relaxivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kandanapitiye, Murthi S.</creatorcontrib><creatorcontrib>Dassanayake, Thiloka M.</creatorcontrib><creatorcontrib>Dassanayake, Arosha C.</creatorcontrib><creatorcontrib>Shelestak, John</creatorcontrib><creatorcontrib>Clements, Robert J.</creatorcontrib><creatorcontrib>Fernando, Can</creatorcontrib><creatorcontrib>Huang, Songping D.</creatorcontrib><jtitle>Advanced healthcare materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kandanapitiye, Murthi S.</au><au>Dassanayake, Thiloka M.</au><au>Dassanayake, Arosha C.</au><au>Shelestak, John</au><au>Clements, Robert J.</au><au>Fernando, Can</au><au>Huang, Songping D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>K2Mn3[FeII(CN)6]2 NPs with High T1‐Relaxivity Attributable to Water Coordination on the Mn(II) Center for Gastrointestinal Tract MR Imaging</atitle><jtitle>Advanced healthcare materials</jtitle><date>2021-10-20</date><risdate>2021</risdate><volume>10</volume><issue>20</issue><epage>n/a</epage><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract>The lack of acid stability in the stomach and of temporal stability when moving through the gastrointestinal (GI) tract has made the development of oral magnetic resonance imaging (MRI) contrast agents based on the platform of Gd3+–complexes problematic.On the other hand, the negative contrast enhancement produced by the T2‐weighted magnetic metal oxide nanoparticles (NPs) often renders the image readout difficult. Biocompatible NPs of the manganese Prussian blue analog K2Mn3[FeII(CN)6]2 exhibit extremely high stability under the acidic conditions of the gastric juice. Additionally, the high r1 relaxivity, low toxicity, and high temporal stability of such NPs offer great potential for the development of a true T1‐weighted oral contrast agent for MRI of the entire GI tract.
Biocompatible nanoparticles (NPs) of the Mn analog of Prussian blue K2Mn3[FeII(CN)6]2 exhibit extremely high stability under the acidic conditions of the gastric juice. The high r1 relaxivity, low toxicity, and high temporal stability of such NPs offer great potential for the development of a true T1‐weighted oral contrast agent for magnetic resonance imaging of the entire gastrointestinal (GI) tract.</abstract><doi>10.1002/adhm.202100987</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1298-8226</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | biocompatible coordination polymers contrast agents magnetic resonance imaging manganese compounds with water coordination nanoparticles Prussian blue relaxivity |
| title | K2Mn3[FeII(CN)6]2 NPs with High T1‐Relaxivity Attributable to Water Coordination on the Mn(II) Center for Gastrointestinal Tract MR Imaging |
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