Capillary and Microchip Electrophoresis

Capillary electrophoresis (CE) is a separation technique employed for the analysis of charged and uncharged species, ranging from small inorganic ions to complex biomolecules. The versatility of CE arises from the many modes of operation such as capillary zone electrophoresis, micellar electrokineti...

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Hauptverfasser: Blanes, Lucas, Gabriel, Ellen Flávia Moreira, Saito, Renata Mayumi, Coltro, Wendell Karlos Tomazelli, Cole, Nerida, Doble, Philip, Roux, Claude, Santos, Robson Oliveira
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creator Blanes, Lucas
Gabriel, Ellen Flávia Moreira
Saito, Renata Mayumi
Coltro, Wendell Karlos Tomazelli
Cole, Nerida
Doble, Philip
Roux, Claude
Santos, Robson Oliveira
description Capillary electrophoresis (CE) is a separation technique employed for the analysis of charged and uncharged species, ranging from small inorganic ions to complex biomolecules. The versatility of CE arises from the many modes of operation such as capillary zone electrophoresis, micellar electrokinetic capillary chromatography, isoelectric focusing, isotachophoresis, capillary electrochromatography and capillary gel electrophoresis. Microchip‐Capillary Electrophoresis (ME) is a miniaturised version of CE where the capillary is replaced by a chip capillary device, which was initially proposed in the early 1990s by Manz and co‐workers. ME offers other potential advantages, particularly for compounds of forensic significance. These include shorter analysis times and lower sample volumes, as well as the potential for creation of disposable devices and automation. Electrochemical detectors (amperometry and conductometry) are commonly used in ME devices due to their high sensitivity and relatively easy implementation.
doi_str_mv 10.1002/9781119373421.ch15
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identifier ISBN: 1119978289
ispartof Analytical Techniques in Forensic Science, 2021, p.407-423
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subjects capillary electrochromatography
capillary electrophoresis
capillary gel electrophoresis
capillary zone electrophoresis
electrochemical detectors
forensic analysis
isoelectric focusing
isotachophoresis
micellar electrokinetic capillary chromatography
microchip‐capillary electrophoresis
title Capillary and Microchip Electrophoresis
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