Factors that Impact the Developability of Drug Candidates

The evaluation of developability mostly involves the integration of research activities in functional areas such as drug metabolism and pharmacokinetic (DMPK), pharmaceutical development, safety assessment, and process chemistry into drug discovery and development process in very early stages of discovery. With the introductions to medicinal chemistry‐ and biotechnology‐based drug discovery and early development, it should be relatively easy to appreciate the complexities of the factors that may affect drug developability directly and indirectly for antibody‐drug conjugates (ADCs). It should be noted that process chemistry and biologics production are large functional areas that can have major impacts on a drug's developability. It is essential that collaboration with these areas is considered early on in order to define the best strategy for drug delivery.