Tykerb Discovery: A Dual EGFR and ERBB2 Tyrosine Kinase Inhibitor

This chapter contains sections titled: Introduction Early Efforts Established the Feasibility of Inhibiting ERBB2 and EGFR Tyrosine Kinase Activity as a Drug Intervention Approach Lead Optimization Efforts Produced Two Drug Candidates with the Desired Mechanism of Action: GW 2974 and GW 0277 Data Re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Lackey, Karen, Cockerill, G. Stuart
Format:	Buchkapitel
Sprache:	eng
Schlagworte:	drug candidate selection inhibiting erbB2 and EGFR tyrosine kinase activity Tykerb discovery ‐ dual EGFR and erbB2 tyrosine kinase inhibitor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	56
container_issue
container_start_page	41
container_title
container_volume
creator	Lackey, Karen Cockerill, G. Stuart
description	This chapter contains sections titled: Introduction Early Efforts Established the Feasibility of Inhibiting ERBB2 and EGFR Tyrosine Kinase Activity as a Drug Intervention Approach Lead Optimization Efforts Produced Two Drug Candidates with the Desired Mechanism of Action: GW 2974 and GW 0277 Data Reanalysis and Mix‐and‐Match Strategy Lead to Tykerb Drug Candidate Selection References
doi_str_mv	10.1002/9780470524961.ch2
format	Book Chapter
fullrecord	<record><control><sourceid>wiley</sourceid><recordid>TN_cdi_wiley_ebooks_10_1002_9780470524961_ch2_ch2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10.1002/9780470524961.ch2</sourcerecordid><originalsourceid>FETCH-LOGICAL-s1122-e7f974437f7ad1a2be7e6d67b41ad07d6831d75c7763b6df7e2b23b11a8c667e3</originalsourceid><addsrcrecordid>eNpVkN1qwkAUhLdIodX6AL3bF4jdsxv3JL2LGq1UKEh6HXazJ7g1JJDtD3n7KkqhA8MwczEXH2OPIGYghHxKMRExirmMUw2z6iBv2PhvEKNLkZjIVN2xaQgf4iQlQGh9z7JiOFJv-cqHqvumfnjmGV99mYbnm_Wem9bxfL9YSF4MfRd8S_zVtyYQ37YHb_1n1z-w29o0gabXnLD3dV4sX6Ld22a7zHZRAJAyIqxTjGOFNRoHRlpC0k6jjcE4gU4nChzOK0StrHY1krRSWQCTVFojqQmDy--Pb2goyXbdMZQgyjOE8h-E8gThbPULdcVN-A</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>book_chapter</recordtype></control><display><type>book_chapter</type><title>Tykerb Discovery: A Dual EGFR and ERBB2 Tyrosine Kinase Inhibitor</title><source>eBooks on EBSCOhost</source><creator>Lackey, Karen ; Cockerill, G. Stuart</creator><contributor>Li, Rongshi ; Stafford, Jeffrey A</contributor><creatorcontrib>Lackey, Karen ; Cockerill, G. Stuart ; Li, Rongshi ; Stafford, Jeffrey A</creatorcontrib><description>This chapter contains sections titled: Introduction Early Efforts Established the Feasibility of Inhibiting ERBB2 and EGFR Tyrosine Kinase Activity as a Drug Intervention Approach Lead Optimization Efforts Produced Two Drug Candidates with the Desired Mechanism of Action: GW 2974 and GW 0277 Data Reanalysis and Mix‐and‐Match Strategy Lead to Tykerb Drug Candidate Selection References</description><identifier>ISBN: 0470278293</identifier><identifier>ISBN: 9780470278291</identifier><identifier>EISBN: 0470524960</identifier><identifier>EISBN: 9780470524961</identifier><identifier>DOI: 10.1002/9780470524961.ch2</identifier><language>eng</language><publisher>Hoboken, NJ, USA: John Wiley & Sons, Inc</publisher><subject>drug candidate selection ; inhibiting erbB2 and EGFR tyrosine kinase activity ; Tykerb discovery ‐ dual EGFR and erbB2 tyrosine kinase inhibitor</subject><ispartof>Kinase Inhibitor Drugs, 2009, p.41-56</ispartof><rights>Copyright © 2009 John Wiley & Sons, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>779,780,784,793,27924</link.rule.ids></links><search><contributor>Li, Rongshi</contributor><contributor>Stafford, Jeffrey A</contributor><creatorcontrib>Lackey, Karen</creatorcontrib><creatorcontrib>Cockerill, G. Stuart</creatorcontrib><title>Tykerb Discovery: A Dual EGFR and ERBB2 Tyrosine Kinase Inhibitor</title><title>Kinase Inhibitor Drugs</title><description>This chapter contains sections titled: Introduction Early Efforts Established the Feasibility of Inhibiting ERBB2 and EGFR Tyrosine Kinase Activity as a Drug Intervention Approach Lead Optimization Efforts Produced Two Drug Candidates with the Desired Mechanism of Action: GW 2974 and GW 0277 Data Reanalysis and Mix‐and‐Match Strategy Lead to Tykerb Drug Candidate Selection References</description><subject>drug candidate selection</subject><subject>inhibiting erbB2 and EGFR tyrosine kinase activity</subject><subject>Tykerb discovery ‐ dual EGFR and erbB2 tyrosine kinase inhibitor</subject><isbn>0470278293</isbn><isbn>9780470278291</isbn><isbn>0470524960</isbn><isbn>9780470524961</isbn><fulltext>true</fulltext><rsrctype>book_chapter</rsrctype><creationdate>2009</creationdate><recordtype>book_chapter</recordtype><sourceid/><recordid>eNpVkN1qwkAUhLdIodX6AL3bF4jdsxv3JL2LGq1UKEh6HXazJ7g1JJDtD3n7KkqhA8MwczEXH2OPIGYghHxKMRExirmMUw2z6iBv2PhvEKNLkZjIVN2xaQgf4iQlQGh9z7JiOFJv-cqHqvumfnjmGV99mYbnm_Wem9bxfL9YSF4MfRd8S_zVtyYQ37YHb_1n1z-w29o0gabXnLD3dV4sX6Ld22a7zHZRAJAyIqxTjGOFNRoHRlpC0k6jjcE4gU4nChzOK0StrHY1krRSWQCTVFojqQmDy--Pb2goyXbdMZQgyjOE8h-E8gThbPULdcVN-A</recordid><startdate>20091002</startdate><enddate>20091002</enddate><creator>Lackey, Karen</creator><creator>Cockerill, G. Stuart</creator><general>John Wiley & Sons, Inc</general><scope/></search><sort><creationdate>20091002</creationdate><title>Tykerb Discovery: A Dual EGFR and ERBB2 Tyrosine Kinase Inhibitor</title><author>Lackey, Karen ; Cockerill, G. Stuart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-s1122-e7f974437f7ad1a2be7e6d67b41ad07d6831d75c7763b6df7e2b23b11a8c667e3</frbrgroupid><rsrctype>book_chapters</rsrctype><prefilter>book_chapters</prefilter><language>eng</language><creationdate>2009</creationdate><topic>drug candidate selection</topic><topic>inhibiting erbB2 and EGFR tyrosine kinase activity</topic><topic>Tykerb discovery ‐ dual EGFR and erbB2 tyrosine kinase inhibitor</topic><toplevel>online_resources</toplevel><creatorcontrib>Lackey, Karen</creatorcontrib><creatorcontrib>Cockerill, G. Stuart</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lackey, Karen</au><au>Cockerill, G. Stuart</au><au>Li, Rongshi</au><au>Stafford, Jeffrey A</au><format>book</format><genre>bookitem</genre><ristype>CHAP</ristype><atitle>Tykerb Discovery: A Dual EGFR and ERBB2 Tyrosine Kinase Inhibitor</atitle><btitle>Kinase Inhibitor Drugs</btitle><date>2009-10-02</date><risdate>2009</risdate><spage>41</spage><epage>56</epage><pages>41-56</pages><isbn>0470278293</isbn><isbn>9780470278291</isbn><eisbn>0470524960</eisbn><eisbn>9780470524961</eisbn><abstract>This chapter contains sections titled: Introduction Early Efforts Established the Feasibility of Inhibiting ERBB2 and EGFR Tyrosine Kinase Activity as a Drug Intervention Approach Lead Optimization Efforts Produced Two Drug Candidates with the Desired Mechanism of Action: GW 2974 and GW 0277 Data Reanalysis and Mix‐and‐Match Strategy Lead to Tykerb Drug Candidate Selection References</abstract><cop>Hoboken, NJ, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/9780470524961.ch2</doi><tpages>16</tpages></addata></record>
fulltext	fulltext
identifier	ISBN: 0470278293
ispartof	Kinase Inhibitor Drugs, 2009, p.41-56
issn
language	eng
recordid	cdi_wiley_ebooks_10_1002_9780470524961_ch2_ch2
source	eBooks on EBSCOhost
subjects	drug candidate selection inhibiting erbB2 and EGFR tyrosine kinase activity Tykerb discovery ‐ dual EGFR and erbB2 tyrosine kinase inhibitor
title	Tykerb Discovery: A Dual EGFR and ERBB2 Tyrosine Kinase Inhibitor
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T12%3A25%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.atitle=Tykerb%20Discovery:%20A%20Dual%20EGFR%20and%20ERBB2%20Tyrosine%20Kinase%20Inhibitor&rft.btitle=Kinase%20Inhibitor%20Drugs&rft.au=Lackey,%20Karen&rft.date=2009-10-02&rft.spage=41&rft.epage=56&rft.pages=41-56&rft.isbn=0470278293&rft.isbn_list=9780470278291&rft_id=info:doi/10.1002/9780470524961.ch2&rft_dat=%3Cwiley%3E10.1002/9780470524961.ch2%3C/wiley%3E%3Curl%3E%3C/url%3E&rft.eisbn=0470524960&rft.eisbn_list=9780470524961&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true