The potentiating effect of KC-404 on prostacyclin-induced vasodilation in isolated human cerebral artery

1. 1. KC-404 (10 −9–10 −6 g/ml) produced concentration-dependent relaxations in human middle cerebral arteries contracted with prostaglandin F 2 a . 2. 2. KC-404 (10 −8 and 10 −7 g/ml) has the ability to significantly potentiate prostaglandin I 2-induced relaxations in human middle cerebral arteries. 3. 3. KC-404, at least in low concentrations, may elicit human cerebral vasodilation predominantly by potentiating relaxant responses to prostaglandin I 2 produced spontaneously in vascular wall. 4. 4. KC-404 is expected to increase cerebral blood flow at least by dilation of major cerebral arteries, and this agent may be beneficial for the treatment of cerebrovascular disorders.