Melatonin — The Hormone of Darkness
The secretion of melatonin is stimulated by darkness. Darkness also characterizes our understanding of the physiology of melatonin in humans. (The name derives from the hormone's ability to lighten the skin of amphibians, a property it is not recognized to have in mammals.) The article by Puig-...
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| Veröffentlicht in: | The New England journal of medicine 1992-11, Vol.327 (19), p.1377-1379 |
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| container_title | The New England journal of medicine |
| container_volume | 327 |
| creator | Utiger, Robert D |
| description | The secretion of melatonin is stimulated by darkness. Darkness also characterizes our understanding of the physiology of melatonin in humans. (The name derives from the hormone's ability to lighten the skin of amphibians, a property it is not recognized to have in mammals.) The article by Puig-Domingo et al. in this issue of the
Journal,
describing a patient with hypogonadotropic hypogonadism, hypermelatoninemia, and pineal calcification, provides an opportunity to let in some light.
1
Melatonin is the predominant product of the still-mysterious pineal gland. This gland is probably the only source of circulating melatonin, since plasma melatonin concentrations after pinealectomy are . . . |
| doi_str_mv | 10.1056/NEJM199211053271909 |
| format | Article |
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Journal,
describing a patient with hypogonadotropic hypogonadism, hypermelatoninemia, and pineal calcification, provides an opportunity to let in some light.
1
Melatonin is the predominant product of the still-mysterious pineal gland. This gland is probably the only source of circulating melatonin, since plasma melatonin concentrations after pinealectomy are . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199211053271909</identifier><identifier>PMID: 1406840</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>BOSTON: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Aged ; Aging ; Animals ; Biological and medical sciences ; Calcinosis - pathology ; Child ; Child, Preschool ; Circadian rhythm ; Female ; Fundamental and applied biological sciences. Psychology ; General & Internal Medicine ; Hormones ; Hormones and neuropeptides. Regulation ; Humans ; Hypogonadism - etiology ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Infant ; Life Sciences & Biomedicine ; Male ; Medicine, General & Internal ; Melatonin ; Melatonin - secretion ; Middle Aged ; Pineal Gland - pathology ; Plasma ; Science & Technology ; Shift work ; Vertebrates: endocrinology</subject><ispartof>The New England journal of medicine, 1992-11, Vol.327 (19), p.1377-1379</ispartof><rights>1993 INIST-CNRS</rights><rights>Copyright Massachusetts Medical Society Nov 5, 1992</rights><rights>Copyright Massachusetts Medical Society, Publishing Division Nov 5, 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>67</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992JW07700009</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c420t-90a47024a04bad285a16e2c79be6b66a85ca18db137768c4affd64b12bd4a5a53</citedby><cites>FETCH-LOGICAL-c420t-90a47024a04bad285a16e2c79be6b66a85ca18db137768c4affd64b12bd4a5a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199211053271909$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1983454499?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,2760,2761,26108,27197,27929,27930,52387,54069,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4418842$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1406840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Utiger, Robert D</creatorcontrib><title>Melatonin — The Hormone of Darkness</title><title>The New England journal of medicine</title><addtitle>NEW ENGL J MED</addtitle><addtitle>N Engl J Med</addtitle><description>The secretion of melatonin is stimulated by darkness. Darkness also characterizes our understanding of the physiology of melatonin in humans. (The name derives from the hormone's ability to lighten the skin of amphibians, a property it is not recognized to have in mammals.) The article by Puig-Domingo et al. in this issue of the
Journal,
describing a patient with hypogonadotropic hypogonadism, hypermelatoninemia, and pineal calcification, provides an opportunity to let in some light.
1
Melatonin is the predominant product of the still-mysterious pineal gland. This gland is probably the only source of circulating melatonin, since plasma melatonin concentrations after pinealectomy are . . .</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcinosis - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Circadian rhythm</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General & Internal Medicine</subject><subject>Hormones</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Humans</subject><subject>Hypogonadism - etiology</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Infant</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medicine, General & Internal</subject><subject>Melatonin</subject><subject>Melatonin - secretion</subject><subject>Middle Aged</subject><subject>Pineal Gland - pathology</subject><subject>Plasma</subject><subject>Science & Technology</subject><subject>Shift work</subject><subject>Vertebrates: endocrinology</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc9OFTEYxRsjwSvyBMZkIuKGjPTPN9N2Sa4gENANxuXkm04nznWmhXYmxJ0P4RPyJHRybyAxYuymac7vO6c9JeQ1ox8YLcrDz8fnl0xrztJJcMk01c_IghVC5AC0fE4WlHKVg9TiBXkZ44qmxUBvk22WdAV0QfYvbY-jd53L7n79zq6-2-zUh8E7m_k2-4jhh7MxviJbLfbR7m72HfL15PhqeZpffPl0tjy6yA1wOuaaIkjKASnU2HBVICstN1LXtqzLElVhkKmmZkLKUhnAtm1KqBmvG8ACC7FD3q99r4O_mWwcq6GLxvY9OuunWEnBBdeUJfDtH-DKT8Glu1WcCw2Kidlt7ymIaSWgANA6UWJNmeBjDLatrkM3YPhZMVrNPVd_6TlNvdl4T_Vgm8eZdbFJf7fRMRrs24DOdPEBA2BKAU_YwRq7tbVvo-msM_aBOppTz79RKeefm0PV_9PLbsSx827pJzc-Bg1DrJxdDf983T0o1K85</recordid><startdate>19921105</startdate><enddate>19921105</enddate><creator>Utiger, Robert D</creator><general>Massachusetts Medical Society</general><general>MASS MEDICAL SOC</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19921105</creationdate><title>Melatonin — The Hormone of Darkness</title><author>Utiger, Robert D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-90a47024a04bad285a16e2c79be6b66a85ca18db137768c4affd64b12bd4a5a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcinosis - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Circadian rhythm</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General & Internal Medicine</topic><topic>Hormones</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Humans</topic><topic>Hypogonadism - etiology</topic><topic>Hypothalamus. Hypophysis. Epiphysis. 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Darkness also characterizes our understanding of the physiology of melatonin in humans. (The name derives from the hormone's ability to lighten the skin of amphibians, a property it is not recognized to have in mammals.) The article by Puig-Domingo et al. in this issue of the
Journal,
describing a patient with hypogonadotropic hypogonadism, hypermelatoninemia, and pineal calcification, provides an opportunity to let in some light.
1
Melatonin is the predominant product of the still-mysterious pineal gland. This gland is probably the only source of circulating melatonin, since plasma melatonin concentrations after pinealectomy are . . .</abstract><cop>BOSTON</cop><pub>Massachusetts Medical Society</pub><pmid>1406840</pmid><doi>10.1056/NEJM199211053271909</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1992-11, Vol.327 (19), p.1377-1379 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_webofscience_primary_A1992JW07700009CitationCount |
| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; NEJM; MEDLINE; ProQuest Central UK/Ireland; EZB Electronic Journals Library |
| subjects | Adolescent Adult Aged Aging Animals Biological and medical sciences Calcinosis - pathology Child Child, Preschool Circadian rhythm Female Fundamental and applied biological sciences. Psychology General & Internal Medicine Hormones Hormones and neuropeptides. Regulation Humans Hypogonadism - etiology Hypothalamus. Hypophysis. Epiphysis. Urophysis Infant Life Sciences & Biomedicine Male Medicine, General & Internal Melatonin Melatonin - secretion Middle Aged Pineal Gland - pathology Plasma Science & Technology Shift work Vertebrates: endocrinology |
| title | Melatonin — The Hormone of Darkness |
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