Clinical Profiles of Gross Hematuria in Autosomal Dominant Polycystic Kidney Disease
There is little information on the characteristics, management, or sequelae of gross hematuria in autosomal dominant polycystic kidney disease (ADPKD). Therefore, we obtained detailed information regarding gross hematuria in 191 adult ADPKD subjects. Forty-two percent (N = 81) experienced at least o...
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| Veröffentlicht in: | American journal of kidney diseases 1992-08, Vol.20 (2), p.140-143 |
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| creator | Gabow, Patricia A. Duley, Irene Johnson, Ann M. |
| description | There is little information on the characteristics, management, or sequelae of gross hematuria in autosomal dominant polycystic kidney disease (ADPKD). Therefore, we obtained detailed information regarding gross hematuria in 191 adult ADPKD subjects. Forty-two percent (N = 81) experienced at least one episode of gross hematuria. The mean age of the initial episode was 30 ± 1 years; only 10% of subjects reported the first episode before age 16. Twentythree percent of those with gross hematuria had experienced more than six occurrences. Sixty-two percent of patients with bleeding indicated a presumptive precipitating event, most commonly urinary tract infection (42% overall, 61 of females v 17% of males, P < 0.01), or sports or strenuous activity (20% of males v 11 % of females, NS). In 56% of subjects, the episode persisted for 2 to 7 days. Hypertensive ADPKD subjects were more likely to have gross hematuria than normotensive subjects (48% v 30%, P < 0.02) and those with gross hematuria had larger renal size (820 ± 87 v 588 ± 52 cm3, P < 0.03). Moreover, those subjects with more episodes of gross hematuria had a higher serum creatinine concentration than those with fewer episodes (serum creatinine: 0 episodes, 120 ± 10 v >5 episodes, 190 ± 30, |
| doi_str_mv | 10.1016/S0272-6386(12)80541-5 |
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Therefore, we obtained detailed information regarding gross hematuria in 191 adult ADPKD subjects. Forty-two percent (N = 81) experienced at least one episode of gross hematuria. The mean age of the initial episode was 30 ± 1 years; only 10% of subjects reported the first episode before age 16. Twentythree percent of those with gross hematuria had experienced more than six occurrences. Sixty-two percent of patients with bleeding indicated a presumptive precipitating event, most commonly urinary tract infection (42% overall, 61 of females v 17% of males, P < 0.01), or sports or strenuous activity (20% of males v 11 % of females, NS). In 56% of subjects, the episode persisted for 2 to 7 days. Hypertensive ADPKD subjects were more likely to have gross hematuria than normotensive subjects (48% v 30%, P < 0.02) and those with gross hematuria had larger renal size (820 ± 87 v 588 ± 52 cm3, P < 0.03). Moreover, those subjects with more episodes of gross hematuria had a higher serum creatinine concentration than those with fewer episodes (serum creatinine: 0 episodes, 120 ± 10 v >5 episodes, 190 ± 30,<mol/L, P < 0.04 [1.4 ± 0.1 v 2.1 ± 0.3 mg/dL]). This association suggests that, although self-limited, cumulative episodes of gross hematuria may have an unfavorable impact on long-term renal function.</description><identifier>ISSN: 0272-6386</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1016/S0272-6386(12)80541-5</identifier><identifier>PMID: 1496966</identifier><language>eng</language><publisher>PHILADELPHIA: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Biological and medical sciences ; Creatinine - blood ; Female ; hematuria ; Hematuria - blood ; Hematuria - etiology ; Humans ; Hypertension, Renal - complications ; Kidneys ; Life Sciences & Biomedicine ; Male ; Malformations of the urinary system ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Polycystic kidney disease ; Polycystic Kidney, Autosomal Dominant - blood ; Polycystic Kidney, Autosomal Dominant - complications ; Science & Technology ; Surveys and Questionnaires ; Urology & Nephrology</subject><ispartof>American journal of kidney diseases, 1992-08, Vol.20 (2), p.140-143</ispartof><rights>1992 National Kidney Foundation. All rights reserved</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>82</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992JH86200004</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c441t-a140f541d6d383b5063ec3fec604be959366f3033c3b460d3f0d49633638d3c53</citedby><cites>FETCH-LOGICAL-c441t-a140f541d6d383b5063ec3fec604be959366f3033c3b460d3f0d49633638d3c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0272-6386(12)80541-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27197,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5509125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1496966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gabow, Patricia A.</creatorcontrib><creatorcontrib>Duley, Irene</creatorcontrib><creatorcontrib>Johnson, Ann M.</creatorcontrib><title>Clinical Profiles of Gross Hematuria in Autosomal Dominant Polycystic Kidney Disease</title><title>American journal of kidney diseases</title><addtitle>AM J KIDNEY DIS</addtitle><addtitle>Am J Kidney Dis</addtitle><description>There is little information on the characteristics, management, or sequelae of gross hematuria in autosomal dominant polycystic kidney disease (ADPKD). Therefore, we obtained detailed information regarding gross hematuria in 191 adult ADPKD subjects. Forty-two percent (N = 81) experienced at least one episode of gross hematuria. The mean age of the initial episode was 30 ± 1 years; only 10% of subjects reported the first episode before age 16. Twentythree percent of those with gross hematuria had experienced more than six occurrences. Sixty-two percent of patients with bleeding indicated a presumptive precipitating event, most commonly urinary tract infection (42% overall, 61 of females v 17% of males, P < 0.01), or sports or strenuous activity (20% of males v 11 % of females, NS). In 56% of subjects, the episode persisted for 2 to 7 days. Hypertensive ADPKD subjects were more likely to have gross hematuria than normotensive subjects (48% v 30%, P < 0.02) and those with gross hematuria had larger renal size (820 ± 87 v 588 ± 52 cm3, P < 0.03). Moreover, those subjects with more episodes of gross hematuria had a higher serum creatinine concentration than those with fewer episodes (serum creatinine: 0 episodes, 120 ± 10 v >5 episodes, 190 ± 30,<mol/L, P < 0.04 [1.4 ± 0.1 v 2.1 ± 0.3 mg/dL]). This association suggests that, although self-limited, cumulative episodes of gross hematuria may have an unfavorable impact on long-term renal function.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>hematuria</subject><subject>Hematuria - blood</subject><subject>Hematuria - etiology</subject><subject>Humans</subject><subject>Hypertension, Renal - complications</subject><subject>Kidneys</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Malformations of the urinary system</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Polycystic kidney disease</subject><subject>Polycystic Kidney, Autosomal Dominant - blood</subject><subject>Polycystic Kidney, Autosomal Dominant - complications</subject><subject>Science & Technology</subject><subject>Surveys and Questionnaires</subject><subject>Urology & Nephrology</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAURi0EKtPCT6jkBUJUKOBH4iarapRCB6hEJcracuxrySixi-2A5t_jNKNhCSsv7vnu4xihc0reUULF-2-EXbJK8Fa8oeyiJU1Nq-YJ2tCG8Uq0vH2KNkfkOTpN6QchpONCnKATWneiE2KD7vvReafViO9isG6EhIPFNzGkhHcwqTxHp7DzeDvnkMJUwOswOa98xndh3Ot9yk7jL8542ONrl0AleIGeWTUmeHl4z9D3jx_u-111-_XmU7-9rXRd01wpWhNb1jbC8JYPDREcNLegBakH6JplV8sJ55oPtSCGW2LK3pyXiwzXDT9Dr9e-DzH8nCFlObmkYRyVhzAneckp6VhLCtisoF4Oi2DlQ3STintJiVxsykebclElKZOPNuUy4PwwYB4mMH9Tq75Sf3Woq1Qc2qi8dumINQ3pKFvavF2x3zAEm7QDr-FIbWnXsc-7VrDyP6QudPv_dO-yyi74Psw-l-jVGoVi_ZeDKA9x4yLoLE1w_7j4D6umsUE</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>Gabow, Patricia A.</creator><creator>Duley, Irene</creator><creator>Johnson, Ann M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920801</creationdate><title>Clinical Profiles of Gross Hematuria in Autosomal Dominant Polycystic Kidney Disease</title><author>Gabow, Patricia A. ; Duley, Irene ; Johnson, Ann M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-a140f541d6d383b5063ec3fec604be959366f3033c3b460d3f0d49633638d3c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>hematuria</topic><topic>Hematuria - blood</topic><topic>Hematuria - etiology</topic><topic>Humans</topic><topic>Hypertension, Renal - complications</topic><topic>Kidneys</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Malformations of the urinary system</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Polycystic kidney disease</topic><topic>Polycystic Kidney, Autosomal Dominant - blood</topic><topic>Polycystic Kidney, Autosomal Dominant - complications</topic><topic>Science & Technology</topic><topic>Surveys and Questionnaires</topic><topic>Urology & Nephrology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gabow, Patricia A.</creatorcontrib><creatorcontrib>Duley, Irene</creatorcontrib><creatorcontrib>Johnson, Ann M.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gabow, Patricia A.</au><au>Duley, Irene</au><au>Johnson, Ann M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Profiles of Gross Hematuria in Autosomal Dominant Polycystic Kidney Disease</atitle><jtitle>American journal of kidney diseases</jtitle><stitle>AM J KIDNEY DIS</stitle><addtitle>Am J Kidney Dis</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>20</volume><issue>2</issue><spage>140</spage><epage>143</epage><pages>140-143</pages><issn>0272-6386</issn><eissn>1523-6838</eissn><abstract>There is little information on the characteristics, management, or sequelae of gross hematuria in autosomal dominant polycystic kidney disease (ADPKD). Therefore, we obtained detailed information regarding gross hematuria in 191 adult ADPKD subjects. Forty-two percent (N = 81) experienced at least one episode of gross hematuria. The mean age of the initial episode was 30 ± 1 years; only 10% of subjects reported the first episode before age 16. Twentythree percent of those with gross hematuria had experienced more than six occurrences. Sixty-two percent of patients with bleeding indicated a presumptive precipitating event, most commonly urinary tract infection (42% overall, 61 of females v 17% of males, P < 0.01), or sports or strenuous activity (20% of males v 11 % of females, NS). In 56% of subjects, the episode persisted for 2 to 7 days. Hypertensive ADPKD subjects were more likely to have gross hematuria than normotensive subjects (48% v 30%, P < 0.02) and those with gross hematuria had larger renal size (820 ± 87 v 588 ± 52 cm3, P < 0.03). Moreover, those subjects with more episodes of gross hematuria had a higher serum creatinine concentration than those with fewer episodes (serum creatinine: 0 episodes, 120 ± 10 v >5 episodes, 190 ± 30,<mol/L, P < 0.04 [1.4 ± 0.1 v 2.1 ± 0.3 mg/dL]). This association suggests that, although self-limited, cumulative episodes of gross hematuria may have an unfavorable impact on long-term renal function.</abstract><cop>PHILADELPHIA</cop><pub>Elsevier Inc</pub><pmid>1496966</pmid><doi>10.1016/S0272-6386(12)80541-5</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Analysis of Variance Biological and medical sciences Creatinine - blood Female hematuria Hematuria - blood Hematuria - etiology Humans Hypertension, Renal - complications Kidneys Life Sciences & Biomedicine Male Malformations of the urinary system Medical sciences Middle Aged Nephrology. Urinary tract diseases Polycystic kidney disease Polycystic Kidney, Autosomal Dominant - blood Polycystic Kidney, Autosomal Dominant - complications Science & Technology Surveys and Questionnaires Urology & Nephrology |
| title | Clinical Profiles of Gross Hematuria in Autosomal Dominant Polycystic Kidney Disease |
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