ELEVATED CONCENTRATIONS OF ENDOGENOUS OUABAIN IN PATIENTS WITH CONGESTIVE-HEART-FAILURE
Background. An endogenous digitalis-like compound in mammals has long been postulated, but only recently has a substance indistinguishable from ouabain been identified in human plasma. Because of the potential significance of such a substance in patients with congestive heart failure, we sought to e...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1992-08, Vol.86 (2), p.420-425 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | GOTTLIEB, SS ROGOWSKI, AC WEINBERG, M KRICHTEN, CM HAMILTON, BP HAMLYN, JM |
| description | Background. An endogenous digitalis-like compound in mammals has long been postulated, but only recently has a substance indistinguishable from ouabain been identified in human plasma. Because of the potential significance of such a substance in patients with congestive heart failure, we sought to evaluate the pathophysiology of endogenous ouabain in these individuals.
Methods and Results. Using an immunoassay, we determined plasma ouabain concentrations in 51 patients with heart failure and in 19 control subjects. Plasma ouabain concentrations in control subjects ranged from 0.16 to 0.77 nM (mean, 0.44+/-0.20 nM). In 19 matched heart failure patients receiving digoxin, the mean ouabain was significantly elevated at 1.59+/-2.2 nM (range, 0.17-8.76 nM, p |
| doi_str_mv | 10.1161/01.CIR.86.2.420 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_A1992JH00900009</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73093546</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-10273e062b68b95d216f5d78cacbc8c50775857f2fb9a42f58a4d896bdc22c163</originalsourceid><addsrcrecordid>eNqN0c9r2zAUB3AxOro023mngQ9ll2FXP6wfPrqukngEeyROexSyLINHYreWw9h_X4WE7DoQCOl93jt8HwBfEYwQYugBoijLN5FgEY5iDD-AGaI4DmNKkhswgxAmIScYfwJ3zv32T0Y4vQW3yP9hSmbgRa7lc1rJpyAri0wW1Sat8rLYBuUikMVTuZRFufOvXfqY5kXgzy8PvNsGL3m1OnUt5bbKn2W4kummChdpvt5t5GfwsdV7Z79c7jnYLWSVrcJ1ucyzdB2aOBZTiCDmxEKGaybqhDYYsZY2XBhtaiMMhZxTQXmL2zrRMW6p0HEjElY3BmODGJmD7-e5r-PwdrRuUofOGbvf694OR6c4gQmh8Qk-nKEZB-dG26rXsTvo8a9CUJ2iVBApH6USTGHlo_Qd3y6jj_XBNv_8OTtfv7_UtTN63466N527MkoxEYx79uPM_th6aJ3pbG_sVaUoSfDPld8TPC3La_H_OusmPXVDnw3HfiLvEHaUPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73093546</pqid></control><display><type>article</type><title>ELEVATED CONCENTRATIONS OF ENDOGENOUS OUABAIN IN PATIENTS WITH CONGESTIVE-HEART-FAILURE</title><source>Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>MEDLINE</source><source>American Heart Association Journals</source><source>Journals@Ovid Ovid Autoload</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>GOTTLIEB, SS ; ROGOWSKI, AC ; WEINBERG, M ; KRICHTEN, CM ; HAMILTON, BP ; HAMLYN, JM</creator><creatorcontrib>GOTTLIEB, SS ; ROGOWSKI, AC ; WEINBERG, M ; KRICHTEN, CM ; HAMILTON, BP ; HAMLYN, JM</creatorcontrib><description>Background. An endogenous digitalis-like compound in mammals has long been postulated, but only recently has a substance indistinguishable from ouabain been identified in human plasma. Because of the potential significance of such a substance in patients with congestive heart failure, we sought to evaluate the pathophysiology of endogenous ouabain in these individuals.
Methods and Results. Using an immunoassay, we determined plasma ouabain concentrations in 51 patients with heart failure and in 19 control subjects. Plasma ouabain concentrations in control subjects ranged from 0.16 to 0.77 nM (mean, 0.44+/-0.20 nM). In 19 matched heart failure patients receiving digoxin, the mean ouabain was significantly elevated at 1.59+/-2.2 nM (range, 0.17-8.76 nM, p<0.05 versus control subjects). The ouabain concentration correlated inversely with both cardiac index (r=-0.62, p<0.005) and mean arterial pressure (r=-0.51, p<0.05). However, there was no correlation between ouabain and left ventricular filling (r=0.19, NS) or right atrial pressures (r=0.20, NS). In 16 heart failure patients not receiving digoxin, the mean ouabain was 1.52+/-2.58 nM. No relation between renal function and ouabain was detected.
Conclusions. The unanticipated lack of correlation of ouabain with atrial pressures indicates that volume is not the chief determinant of ouabain concentration in patients with congestive heart failure. However, the significant relations of plasma ouabain concentration with cardiac index and mean arterial pressure imply that endogenous ouabain may be an important homeostatic factor in humans.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.86.2.420</identifier><identifier>PMID: 1322253</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>DALLAS: Amer Heart Assoc</publisher><subject>Biological and medical sciences ; Cardiac & Cardiovascular Systems ; Cardiology. Vascular system ; Cardiovascular System & Cardiology ; Digoxin - therapeutic use ; Female ; Glomerular Filtration Rate ; Heart ; Heart Failure - blood ; Heart Failure - drug therapy ; Heart Failure - physiopathology ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Hemodynamics - physiology ; Homeostasis - physiology ; Humans ; Immunoassay ; Life Sciences & Biomedicine ; Male ; Medical sciences ; Middle Aged ; Ouabain - blood ; Peripheral Vascular Disease ; Science & Technology ; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors</subject><ispartof>Circulation (New York, N.Y.), 1992-08, Vol.86 (2), p.420-425</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>192</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992JH00900009</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c448t-10273e062b68b95d216f5d78cacbc8c50775857f2fb9a42f58a4d896bdc22c163</citedby><cites>FETCH-LOGICAL-c448t-10273e062b68b95d216f5d78cacbc8c50775857f2fb9a42f58a4d896bdc22c163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3688,27197,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5523867$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1322253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOTTLIEB, SS</creatorcontrib><creatorcontrib>ROGOWSKI, AC</creatorcontrib><creatorcontrib>WEINBERG, M</creatorcontrib><creatorcontrib>KRICHTEN, CM</creatorcontrib><creatorcontrib>HAMILTON, BP</creatorcontrib><creatorcontrib>HAMLYN, JM</creatorcontrib><title>ELEVATED CONCENTRATIONS OF ENDOGENOUS OUABAIN IN PATIENTS WITH CONGESTIVE-HEART-FAILURE</title><title>Circulation (New York, N.Y.)</title><addtitle>CIRCULATION</addtitle><addtitle>Circulation</addtitle><description>Background. An endogenous digitalis-like compound in mammals has long been postulated, but only recently has a substance indistinguishable from ouabain been identified in human plasma. Because of the potential significance of such a substance in patients with congestive heart failure, we sought to evaluate the pathophysiology of endogenous ouabain in these individuals.
Methods and Results. Using an immunoassay, we determined plasma ouabain concentrations in 51 patients with heart failure and in 19 control subjects. Plasma ouabain concentrations in control subjects ranged from 0.16 to 0.77 nM (mean, 0.44+/-0.20 nM). In 19 matched heart failure patients receiving digoxin, the mean ouabain was significantly elevated at 1.59+/-2.2 nM (range, 0.17-8.76 nM, p<0.05 versus control subjects). The ouabain concentration correlated inversely with both cardiac index (r=-0.62, p<0.005) and mean arterial pressure (r=-0.51, p<0.05). However, there was no correlation between ouabain and left ventricular filling (r=0.19, NS) or right atrial pressures (r=0.20, NS). In 16 heart failure patients not receiving digoxin, the mean ouabain was 1.52+/-2.58 nM. No relation between renal function and ouabain was detected.
Conclusions. The unanticipated lack of correlation of ouabain with atrial pressures indicates that volume is not the chief determinant of ouabain concentration in patients with congestive heart failure. However, the significant relations of plasma ouabain concentration with cardiac index and mean arterial pressure imply that endogenous ouabain may be an important homeostatic factor in humans.</description><subject>Biological and medical sciences</subject><subject>Cardiac & Cardiovascular Systems</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular System & Cardiology</subject><subject>Digoxin - therapeutic use</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Heart</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - physiopathology</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Hemodynamics - physiology</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ouabain - blood</subject><subject>Peripheral Vascular Disease</subject><subject>Science & Technology</subject><subject>Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqN0c9r2zAUB3AxOro023mngQ9ll2FXP6wfPrqukngEeyROexSyLINHYreWw9h_X4WE7DoQCOl93jt8HwBfEYwQYugBoijLN5FgEY5iDD-AGaI4DmNKkhswgxAmIScYfwJ3zv32T0Y4vQW3yP9hSmbgRa7lc1rJpyAri0wW1Sat8rLYBuUikMVTuZRFufOvXfqY5kXgzy8PvNsGL3m1OnUt5bbKn2W4kummChdpvt5t5GfwsdV7Z79c7jnYLWSVrcJ1ucyzdB2aOBZTiCDmxEKGaybqhDYYsZY2XBhtaiMMhZxTQXmL2zrRMW6p0HEjElY3BmODGJmD7-e5r-PwdrRuUofOGbvf694OR6c4gQmh8Qk-nKEZB-dG26rXsTvo8a9CUJ2iVBApH6USTGHlo_Qd3y6jj_XBNv_8OTtfv7_UtTN63466N527MkoxEYx79uPM_th6aJ3pbG_sVaUoSfDPld8TPC3La_H_OusmPXVDnw3HfiLvEHaUPw</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>GOTTLIEB, SS</creator><creator>ROGOWSKI, AC</creator><creator>WEINBERG, M</creator><creator>KRICHTEN, CM</creator><creator>HAMILTON, BP</creator><creator>HAMLYN, JM</creator><general>Amer Heart Assoc</general><general>Lippincott Williams & Wilkins</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920801</creationdate><title>ELEVATED CONCENTRATIONS OF ENDOGENOUS OUABAIN IN PATIENTS WITH CONGESTIVE-HEART-FAILURE</title><author>GOTTLIEB, SS ; ROGOWSKI, AC ; WEINBERG, M ; KRICHTEN, CM ; HAMILTON, BP ; HAMLYN, JM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-10273e062b68b95d216f5d78cacbc8c50775857f2fb9a42f58a4d896bdc22c163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biological and medical sciences</topic><topic>Cardiac & Cardiovascular Systems</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular System & Cardiology</topic><topic>Digoxin - therapeutic use</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Heart</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - physiopathology</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Hemodynamics - physiology</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ouabain - blood</topic><topic>Peripheral Vascular Disease</topic><topic>Science & Technology</topic><topic>Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOTTLIEB, SS</creatorcontrib><creatorcontrib>ROGOWSKI, AC</creatorcontrib><creatorcontrib>WEINBERG, M</creatorcontrib><creatorcontrib>KRICHTEN, CM</creatorcontrib><creatorcontrib>HAMILTON, BP</creatorcontrib><creatorcontrib>HAMLYN, JM</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOTTLIEB, SS</au><au>ROGOWSKI, AC</au><au>WEINBERG, M</au><au>KRICHTEN, CM</au><au>HAMILTON, BP</au><au>HAMLYN, JM</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ELEVATED CONCENTRATIONS OF ENDOGENOUS OUABAIN IN PATIENTS WITH CONGESTIVE-HEART-FAILURE</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><stitle>CIRCULATION</stitle><addtitle>Circulation</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>86</volume><issue>2</issue><spage>420</spage><epage>425</epage><pages>420-425</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Background. An endogenous digitalis-like compound in mammals has long been postulated, but only recently has a substance indistinguishable from ouabain been identified in human plasma. Because of the potential significance of such a substance in patients with congestive heart failure, we sought to evaluate the pathophysiology of endogenous ouabain in these individuals.
Methods and Results. Using an immunoassay, we determined plasma ouabain concentrations in 51 patients with heart failure and in 19 control subjects. Plasma ouabain concentrations in control subjects ranged from 0.16 to 0.77 nM (mean, 0.44+/-0.20 nM). In 19 matched heart failure patients receiving digoxin, the mean ouabain was significantly elevated at 1.59+/-2.2 nM (range, 0.17-8.76 nM, p<0.05 versus control subjects). The ouabain concentration correlated inversely with both cardiac index (r=-0.62, p<0.005) and mean arterial pressure (r=-0.51, p<0.05). However, there was no correlation between ouabain and left ventricular filling (r=0.19, NS) or right atrial pressures (r=0.20, NS). In 16 heart failure patients not receiving digoxin, the mean ouabain was 1.52+/-2.58 nM. No relation between renal function and ouabain was detected.
Conclusions. The unanticipated lack of correlation of ouabain with atrial pressures indicates that volume is not the chief determinant of ouabain concentration in patients with congestive heart failure. However, the significant relations of plasma ouabain concentration with cardiac index and mean arterial pressure imply that endogenous ouabain may be an important homeostatic factor in humans.</abstract><cop>DALLAS</cop><pub>Amer Heart Assoc</pub><pmid>1322253</pmid><doi>10.1161/01.CIR.86.2.420</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 1992-08, Vol.86 (2), p.420-425 |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; American Heart Association Journals; Journals@Ovid Ovid Autoload; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Cardiac & Cardiovascular Systems Cardiology. Vascular system Cardiovascular System & Cardiology Digoxin - therapeutic use Female Glomerular Filtration Rate Heart Heart Failure - blood Heart Failure - drug therapy Heart Failure - physiopathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hemodynamics - physiology Homeostasis - physiology Humans Immunoassay Life Sciences & Biomedicine Male Medical sciences Middle Aged Ouabain - blood Peripheral Vascular Disease Science & Technology Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors |
| title | ELEVATED CONCENTRATIONS OF ENDOGENOUS OUABAIN IN PATIENTS WITH CONGESTIVE-HEART-FAILURE |
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