Hepatotoxicity associated with sustained-release niacin
Niacin (nicotinic acid) is a widely used agent in the treatment of hyperlipidemias characterized by elevated low-density lipoprotein and very-low- density lipoprotein. The tendency of the conventional crystalline niacin to cause flushing has limited its use in many patients. Sustained-release (SR) n...
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| Veröffentlicht in: | The American journal of medicine 1992-07, Vol.93 (1), p.102-104 |
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| container_title | The American journal of medicine |
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| creator | Dalton, Thomas A. Berry, Robert S. |
| description | Niacin (nicotinic acid) is a widely used agent in the treatment of hyperlipidemias characterized by elevated low-density lipoprotein and very-low- density lipoprotein. The tendency of the conventional crystalline niacin to cause flushing has limited its use in many patients. Sustained-release (SR) niacin preparations are increasingly utilized due to a lower incidence of flushing and convenient dosing frequency. Although gastrointestinal and hepatotoxic side effects are common to both formulations, they are more frequent and occasionally more severe with the SR preparations. We describe a patient who developed an acute illness characterized by hypothermia, hypotension, metabolic acidosis, and severe hepatic dysfunction 2 days after substitution of an SR preparation for a previously well-tolerated crystalline niacin. |
| doi_str_mv | 10.1016/0002-9343(92)90689-9 |
| format | Article |
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We describe a patient who developed an acute illness characterized by hypothermia, hypotension, metabolic acidosis, and severe hepatic dysfunction 2 days after substitution of an SR preparation for a previously well-tolerated crystalline niacin.</description><subject>Aged</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Delayed-Action Preparations</subject><subject>Disease</subject><subject>Drug therapy</subject><subject>Female</subject><subject>General & Internal Medicine</subject><subject>Humans</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Medical research</subject><subject>Medicine, General & Internal</subject><subject>Niacin - administration & dosage</subject><subject>Niacin - adverse effects</subject><subject>Science & Technology</subject><subject>Side effects</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkF1LHDEUhkOx6Hbbf6CweFFayth8TDKTm8IyqKsseON9yCRnMLI7WZNM7f77ZphFwQvx6nA4z_uSPAidEnxBMBG_Mca0kKxkPyT9KbGoZSE_oRnhnBcVEfQIzV6QE_Qlxse8YsnFMTrOZ8F5NUPVCnY6-eT_OePSfqFj9MbpBHbx7NLDIg4xadeDLQJsQEdY9E4b139Fnzu9ifDtMOfo_uryvlkV67vrm2a5LkxJeCpqI6pKWNLWRHNLhTYSWNdKgVuiaynBaAuMVMZ2taSGQ2faSremlBYoLtkcfZ9qd8E_DRCT2rpoYLPRPfghKiJqSitKM3j-Bnz0Q-jz0xRllGHGyjpD5QSZ4GMM0KldcFsd9opgNTpVozA1ClMyz9Fp3ubo7NA9tFuwr6FJYr7X0_0ZWt9F46A38EItiZT0tslkLieycUkn5_vGD33K0V8fj2b6z0RDNv7XQVCHhHUBTFLWu_d_8h8rMacn</recordid><startdate>19920701</startdate><enddate>19920701</enddate><creator>Dalton, Thomas A.</creator><creator>Berry, Robert S.</creator><general>Elsevier Inc</general><general>EXCERPTA MEDICA INC</general><general>Elsevier Sequoia S.A</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19920701</creationdate><title>Hepatotoxicity associated with sustained-release niacin</title><author>Dalton, Thomas A. ; Berry, Robert S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-8c6776d1b81a5d26ac9e3fb960b1a899ecade317cdf892c5efcb7abc49de2043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aged</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Delayed-Action Preparations</topic><topic>Disease</topic><topic>Drug therapy</topic><topic>Female</topic><topic>General & Internal Medicine</topic><topic>Humans</topic><topic>Hyperlipidemias - drug therapy</topic><topic>Life Sciences & Biomedicine</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Medical research</topic><topic>Medicine, General & Internal</topic><topic>Niacin - administration & dosage</topic><topic>Niacin - adverse effects</topic><topic>Science & Technology</topic><topic>Side effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dalton, Thomas A.</creatorcontrib><creatorcontrib>Berry, Robert S.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dalton, Thomas A.</au><au>Berry, Robert S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatotoxicity associated with sustained-release niacin</atitle><jtitle>The American journal of medicine</jtitle><stitle>AM J MED</stitle><addtitle>Am J Med</addtitle><date>1992-07-01</date><risdate>1992</risdate><volume>93</volume><issue>1</issue><spage>102</spage><epage>104</epage><pages>102-104</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><coden>AJMEAZ</coden><abstract>Niacin (nicotinic acid) is a widely used agent in the treatment of hyperlipidemias characterized by elevated low-density lipoprotein and very-low- density lipoprotein. The tendency of the conventional crystalline niacin to cause flushing has limited its use in many patients. Sustained-release (SR) niacin preparations are increasingly utilized due to a lower incidence of flushing and convenient dosing frequency. Although gastrointestinal and hepatotoxic side effects are common to both formulations, they are more frequent and occasionally more severe with the SR preparations. We describe a patient who developed an acute illness characterized by hypothermia, hypotension, metabolic acidosis, and severe hepatic dysfunction 2 days after substitution of an SR preparation for a previously well-tolerated crystalline niacin.</abstract><cop>NEW YORK</cop><pub>Elsevier Inc</pub><pmid>1626557</pmid><doi>10.1016/0002-9343(92)90689-9</doi><tpages>3</tpages></addata></record> |
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| ispartof | The American journal of medicine, 1992-07, Vol.93 (1), p.102-104 |
| issn | 0002-9343 1555-7162 |
| language | eng |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Chemical and Drug Induced Liver Injury - etiology Delayed-Action Preparations Disease Drug therapy Female General & Internal Medicine Humans Hyperlipidemias - drug therapy Life Sciences & Biomedicine Liver Liver - drug effects Medical research Medicine, General & Internal Niacin - administration & dosage Niacin - adverse effects Science & Technology Side effects |
| title | Hepatotoxicity associated with sustained-release niacin |
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